“…70 The FDA has approved the use of CaCO 3 (without specifying its polymorphism) as a food additive ( §582.1191), a dietary supplement ( §582.5191), a direct food substance ( §184.1191), and a colour additive for food ( §73. 70 to macromolecules (proteins, 77,81,82 growth factors, 83 genes 84,85 ) and inorganic nanoparticles (Ag, 86 ). Importantly, multicomponent encapsulation into VCC is also possible and has been reported (e.g.…”