Hybrid Breakdown Caused by Substitution of the X Chromosome Between Two Mouse Subspecies

Oka, Atsuhiro; Mita, Akihiko; Sakurai-Yamatani, Noriko; Yamamoto, Hiromi; Takagi, Nobuo; Takano-Shimizu, Toshiyuki; Toshimori, Kiyotaka; Moriwaki, Kazuo; Shiroishi, Toshihiko

doi:10.1534/genetics.166.2.913

Cited by 119 publications

(154 citation statements)

References 29 publications

(5 reference statements)

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“…One possibility is that the replacement occurred as a consequence of random drift, as postulated earlier for the replacement of CAS by MUS mtDNA haplotypes under the 'CAS first' scenario. However, other possibilities are worthy of mention, including more effective long-distance dispersal of male mice across hybrid zones (Hare, 2001;Wen et al, 2004) and the possibility of differential production of abnormal sperm types in inter-subspecies hybrids involving males of CAS vs MUS Y chromosome type (Oka et al, 2004).…”

Section: Who Arrived First -Cas or Mus?mentioning

confidence: 99%

Phylogeographic origin of Hokkaido house mice (Mus musculus) as indicated by genetic markers with maternal, paternal and biparental inheritance

et al. 2006

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We examined intraspecies genetic variation in house mice (Mus musculus molossinus) from the northern third of the Japanese Islands, in order to obtain evidence of the history of mouse colonization that might have shaped the current genetic diversity. We extended the previous sampling of mitochondrial cytochrome b sequence and added information from the Y-linked Sry gene and ribosomal RNA gene surveys. We distinguish mitochondrial haplotypes characteristic of the North Asian musculus subspecies group (involving M. m. musculus and M. m. molossinus) as 'MUS', and that of the Southeast Asian castaneus subspecies group as 'CAS' (although the mice resemble MUS morphologically). There was a clear geographic partition of MUS and CAS types into southern and northern Hokkaido, respectively. Conversely, on Tohoku, the MUS and CAS types were interspersed without clear geographic subdivision. In contrast to the mtDNA data, all Hokkaido and Tohoku mice examined were found to possess a unique type for the Y-linked Sry gene, specific to Korea and Japan. Restriction site analysis of nuclear rDNA probe showed a consistent distribution of MUS and CAS types, as major and minor components, respectively, in the Hokkaido and Tohoku mice. These data support the previous notion that the Hokkaido and Tohoku mice experienced genetic hybridization between primary residents of CAS origin and MUS newcomers arriving via a southern route. The invasion of the MUS type could correspond with the evidence for arrival of prehistoric peoples. There are, however, alternative interpretations, including genetic admixture between MUS arriving by a southern route and CAS from a northern route.

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Section: Who Arrived First -Cas or Mus?mentioning

confidence: 99%

Phylogeographic origin of Hokkaido house mice (Mus musculus) as indicated by genetic markers with maternal, paternal and biparental inheritance

et al. 2006

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“…Substantial effort directed toward finding the incompatibilities that underlie hybrid male sterility between M. m. domesticus and M. m. musculus has revealed some genetic patterns. First, the X chromosome is an important contributor (Oka et al 2004;Storchová et al 2004;Britton-Davidian et al 2005;Good et al 2008aGood et al ,b, 2010Vyskočilová et al 2009). F 1 's from most crosses follow Haldane's rule (Haldane 1922), with hybrid females showing few signs of sterility.…”

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confidence: 99%

Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice

et al. 2011

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Reproductive isolation between species is often caused by deleterious interactions among loci in hybrids. Finding the genes involved in these incompatibilities provides insight into the mechanisms of speciation. With recently diverged subspecies, house mice provide a powerful system for understanding the genetics of reproductive isolation early in the speciation process. Although previous studies have yielded important clues about the genetics of hybrid male sterility in house mice, they have been restricted to F 1 sterility or incompatibilities involving the X chromosome. To provide a more complete characterization of this key reproductive barrier, we conducted an F 2 intercross between wild-derived inbred strains from two subspecies of house mice, Mus musculus musculus and Mus musculus domesticus. We identified a suite of autosomal and X-linked QTL that underlie measures of hybrid male sterility, including testis weight, sperm density, and sperm morphology. In many cases, the autosomal loci were unique to a specific sterility trait and exhibited an effect only when homozygous, underscoring the importance of examining reproductive barriers beyond the F 1 generation. We also found novel two-locus incompatibilities between the M. m. musculus X chromosome and M. m. domesticus autosomal alleles. Our results reveal a complex genetic architecture for hybrid male sterility and suggest a prominent role for reproductive barriers in advanced generations in maintaining subspecies integrity in house mice.

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“…Genetic studies in Drosophila demonstrated an excess of hybrid sterility loci on the X chromosome, a phenomenon referred to as Flarge X-effect_ (Orr & Coyne 1989, Tao et al 2003. Several X-linked hybrid sterility loci were also reported in mice (Oka et al 2004, Storchova et al 2004. These genetic studies suggest that hybrid sterility might be caused by incompatibility of multiple loci (or genes).…”

Section: Implications Of X-linked Meiosis Factorsmentioning

confidence: 99%

The role of spermatogonially expressed germ cell-specific genes in mammalian meiosis

Wang

Pan

2007

Chromosome Res

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Meiosis, a hallmark of sexual reproduction, reduces the chromatin complement by half to cope with genome doubling at fertilization and permits exchange of genetic material between parental genomes. Recent functional studies of novel proteins have greatly enhanced our understanding of the regulation of meiosis. The unique status of sex chromosomes in the male germ line may have shaped their content of germ line-intrinsic genes during evolution. Previously, a unique set of 36 spermatogonially expressed, mouse germ cell-specific genes was identified in one genomic screen. Thirteen of these genes have been disrupted in mice and two-thirds of these mouse mutants exhibit meiotic defects. Therefore, we hypothesize that the majority of uncharacterized germ cellspecific genes identified in the same screen, including 11 X-linked genes, might also play important roles in meiosis. In particular, we cite previously unpublished studies demonstrating that the NXF2 protein, an X-encoded factor, is present in early spermatocytes.

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Hybrid Breakdown Caused by Substitution of the X Chromosome Between Two Mouse Subspecies

Cited by 119 publications

References 29 publications

Phylogeographic origin of Hokkaido house mice (Mus musculus) as indicated by genetic markers with maternal, paternal and biparental inheritance

Phylogeographic origin of Hokkaido house mice (Mus musculus) as indicated by genetic markers with maternal, paternal and biparental inheritance

Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice

The role of spermatogonially expressed germ cell-specific genes in mammalian meiosis

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