Hybrid Blood Collection Tubes: Combining the Best Attributes of Glass and Plastic for Safety and Shelf life

Abstract

SiO2 Medical Products, Inc. developed hybrid blood collection tubes (BCTs) that combine the breakage resistance of plastic and a shelf life approaching that of glass. These blended attributes provide improved BCT safety and reliability for patients and clinical workers. A shelf life of at least 2 y with less than 10% draw volume variation was demonstrated on evacuated hybrid BCTs, which is approximately 7 times longer than standard polyethylene terephthalate (PET) BCTs. This translates into more consistent and reliable blood draw volumes over a longer shelf life. The moisture vapor barrier of hybrid BCTs is 5 times lower than that of PET BCTs, which significantly reduces preservative evaporation over their shelf life. As a result, the risk of preservative gelation and alteration to the blood-to-preservative ratio mix is practically eliminated. Cyclic olefin polymer (COP) exhibits superior impact resistance to breakage because of its high ductility and impact strength and is not influenced by defects and flaws as is glass. Although COP has a mechanical toughness comparable with that of PET, it maintains this over a wider range of temperatures (–70 to 121 °C). As a result, COP can tolerate steam sterilization and cold storage temperatures without mechanical fatigue, deformation, or breakage. Lastly, extreme centrifugation of water-filled BCTs did not impose breakage of any kind.

Accuracy of Citrate Anticoagulant Amount, Volume, and Concentration in Evacuated Blood Collection Tubes Evaluated with UV Molecular Absorption Spectrometry on a Purified Water Model

“…Regarding our previous experiences, approximately a 5% increase in draw volume compensates for the altitude of our experimental setting. Lippi et al also confirmed the adequate quality of the citrate tubes regarding their draw volume [ 26 ], and new materials are promising to limit the time-dependent decrease in draw volume [ 27 ], which we observed.…”

Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development

“…This SiO 2 primary container combines a cyclic olefin polymer with nanolayer glass as the inner layer, achieved through plasma-enhanced chemical vapor deposition. This innovative SiO 2 vial demonstrates exceptional resistance to physical, thermal, and chemical stress over its lifespan, eliminating concerns of breakage or leakage …”

“…This innovative SiO 2 vial demonstrates exceptional resistance to physical, thermal, and chemical stress over its lifespan, eliminating concerns of breakage or leakage. 193 …”

Validation of Vacuum Consistency of The Internal Evacuated Blood Collection Tube (BCT)

“…Thus, in the scope of manufacturing and processing material are Low-Density Polyethylene (LDPE), Bromobutyl Rubber, and Polyethylene terephthalate (PET), respectively. The most common shelf life for a polymer base BCT is known to be a minimal time of more than 12 months [6,7] compared to glass base BCT generally limited by the shelf life of the additive due to the minimal losses of vacuum and water vapour, over time [2]. In addition, the Rubber Stopper material is poor at radiation resistance pertaining to its drawback factor [8].…”

“…Also, there are two types of BCT which are Hemogard and Regular [10]. There is usage for adult, pediatric and fingerstick which hold 3 to 10 ml of blood, 2 to 4 ml and one-half ml, respectively [6]. Thus, this research focuses on verifying and validating the consistency of vacuum inside the Vacutainer® [11] with hemogard (plastic/polymer material) [12].…”