Hybrid Bio-Based Silicone Coatings with Anti-adhesive Properties

Abstract

Hybrid polysiloxanes and polysilsesquioxanes grafted with naturally occurring bioactive phytochemicals: eugenol and linalool, were synthesized and investigated with regard to their structure and properties. The two series of materials, differing in the type of inorganic structure and the content of active groups, were coated onto the surface of glass plates, and their antibiofilm activities against bacteria Aeromonas hydrophila were assessed by luminometry and fluorescence microscopy. Bioactivity was correlated with specific properties of the hybrid coatings (chemical structure, surface free energy and adhesiveness). The functionalized polysilsesquioxanes exhibited the most favorable anti-adhesive effects. Cell adhesion after 6 days of incubation, expressed as RLU/cm2, was significantly reduced (44 and 67 for, respectively, Z-E-100 and Z-L-100, compared to 517 for the control glass carrier). The surface stickiness of polysiloxane films deteriorated their anti-adhesion properties, despite the presence of a large amount of bioactive species.

One-step synthesis of amphiphilic copolymers PDMS-b-PEG using tris(pentafluorophenyl)borane and subsequent study of encapsulation and release of curcumin

“…The same behavior was observed in PR12. However, Nowacka M. et al 53 have previously demonstrated the coupling between PDMS and triethoxysilanes with organic compounds (OC) based on the shift towards upfield of the Si–O (M) and O–Si–O (D) units in the 29 Si NMR spectrum. We observed a similar behavior in our 29 Si NMR spectra (Fig.…”

Self-Healing Antimicrobial Silicones—Mechanisms and Applications

“…The antimicrobial and antibiofilm properties of superhydrophobic silicone coatings were derived as a result of the synergistic effects of the active components used (e.g., a composite of MOF, triclosan, epoxy resin, and polydimethylsiloxane [40]). Recently, our group has implemented a novel approach for modification of silicones with specific organic groups, including grafting polysiloxane backbones with naturally occurring bioactive phytochemicals: N-acetylcysteine [41,42], eugenol, and linalool [43] as well as polar but not ionic 2-(carboxymethylthioethyl)-, 2-(npropylamidomethylthioethyl)-, and 2-(mercaptoethylamidomethylthioethyl)-groups [44]. We have shown that the specific functionalization of polysiloxanes may increase their antiadhesive properties against a range of prokaryotic and eukaryotic microorganisms of different cell organization and cell wall structures, irrespective of the properties (hydrophobicity or hydrophilicity) of silicone materials.…”