Hybrid bicelles as a pH-sensitive nanocarrier for hydrophobic drug delivery

Li, Lin; Wang, Xiaoyou; Guo, Yanyu; Li, Xiaoda; Jing, Lijia; Yue, Xiuli; Zhang, Qiang; Dai, Zhifei

doi:10.1039/c6ra18112k

Cited by 32 publications

(33 citation statements)

References 69 publications

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“…Thanks to its hydrophobicity and cationic charge, DOX was readily loaded into DPPC/SC‐C 5 bicelles (Figure S15), and Dai et al. recently reported that bicelles successfully served as carriers for DOX . The resulting DPPC/SC‐C 5 /DOX bicelles, at a concentration of 0.1 wt % (net concentration of DOX=24 μ m ), were mixed with HepB3B cells in EMEM containing 10 % FBS, and incubated either in the bicelle state (25 °C) or in the micelle state (37 °C).…”

Section: Figurementioning

confidence: 99%

Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications

et al. 2018

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Mixtures of a phospholipid (1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine, DPPC) and a sodium-cholate-derived surfactant (SC-C ) at room temperature formed phospholipid bilayer fragments that were edge-stabilized by SC-C : so-called "bicelles". Because the bilayer melting point of DPPC (41 °C) is above room temperature and because SC-C has an exceptionally low critical micelle concentration (<0.5 mm), the bicelles are kinetically frozen at room temperature. Consequently, they exist even when the mixture is diluted to a concentration of 0.04 wt %. In addition, the lateral size of the bicelles can be fine-tuned by altering the molar ratio of DPPC to SC-C . On heating to ≈37 °C, the bicelles transformed into micelles composed of DPPC and SC-C . By taking advantage of the dilution tolerance, size tunability, and thermoresponsiveness, we demonstrated in vitro drug delivery based on use of the bicelles as carriers, which suggests their potential utility in transdermal drug delivery.

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Section: Figurementioning

confidence: 99%

Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications

et al. 2018

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“…Lin et al reported the formation of hydrophobic doxorubicin loaded hybrid bicelles generated from CFL and short phospholipids DHPC at the ratio of 7:2 via traditional thin film hydration method ( Figure 16). [52] It was found that the disc-like bicelles displayed similar significantly high stability to cerasome vesicles, but they had higher cellular uptake than spherical cerasomes. More importantly, drug-loaded bicelles exhibited pH-sensitive release behavior and could effectively inhibit the tumor growth.…”

Section: Novel Cerasomesmentioning

confidence: 99%

“…[50,51] Such hybrid bicelles have received widespread attention owing to the presence of the polyorganosiloxane surface, which offers remarkably higher stability than conventional phospholipid bicelles. [50,52] Moreover, such disc-like nanoparticles exhibit preferential cellular uptake and higher microvascular adhesion than spherical nanoparticles. [53][54][55][56][57] In addition, hybrid bicelles are capable of encapusulating hydrophobic drugs.…”

Section: Novel Cerasomesmentioning

confidence: 99%

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 Progress of Liposomal Nanohybrid Cerasomes as Novel Drug Nanocarriers

Li¹,

Jiang²,

Zhu³

et al. 2017

Gen. Chem.

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Despite many benefits, liposomes have still not realized their full potential as vehicles for drug delivery due to the morphological instability. Recently, liposomal nanohybrid cerasomes have been developed as novel drug nanocarriers based on organoalkoxysilane through a sol-gel reaction in combination with self-assembly process. The presence of polyorganosiloxane network on the surface imparts cerasomes higher morphological stability than conventional liposomes and the incorporation of liposomal bilayer structure into cerasomes boosts the biocompatibility in comparision with silica nanoparticles with similar size. Moreover, cerasomes are able to encapsulate various drug molecules and exhibit controlled drug release profile. In addition, cerasomes are easy to be conjugated with biomolecules through silane-coupler chemistry due to the silanols on the surface. Therefore, cerasomes are expected to be ideal drug delivery systems owning to the unique advantages. The present paper will briefly introduce the preparation and properties of cerasomes, followed by reviewing the progress of cerasomes for drug delivery.

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“…The planar bilayer region enriched in the long-chain lipids provides a favorable environment to study membrane proteins using various techniques, such as nuclear magnetic resonance (NMR), [4][5][6][7][8][9][10][11] X-ray crystallography, [12][13][14][15][16] and spectroscopy techniques. [17][18][19][20][21] Bicelles can also be used as delivery vehicles for membrane proteins or drugs, 22,23 or as templates for the synthesis of platinum nanowheels.…”

Section: Introductionmentioning

confidence: 99%

Phase behavior of a binary lipid system containing long- and short-chain phosphatidylcholines

Sun

et al. 2017

RSC Adv.

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Bilayered micelles, or so-called bicelles, are generally made of long-and short-chain lipids. They are extensively used as model membranes to study the structure of membrane-associated peptides or proteins and their interactions with membranes. However, the phase behavior of lipid mixtures composed of longand short-chain lipids, especially at low temperatures, is still not very clear. In this work, the most commonly used long-chain lipid, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and a short-chain lipid, 1,2-dioctanoyl-sn-glycero-3-phosphocholine (diC8PC), were selected as a bicellar model to study their phase behavior. Over the whole range of DPPC/diC8PC molar ratios (q) studied in this work, a lamellar crystalline phase (L c 0 ) enriched in DPPC was found to be the most stable phase at 5 C, together with a diC8PC-enriched micelle phase. Interestingly, a metastable phase, named the U phase in this work, was observed in the mixtures with a DPPC/diC8PC molar ratio between 1 and 4. The metastable U phase was found to be lacking in long-range order in the direction of the bilayer surface normal, but bearing a different "crystalline phase-like" hydrocarbon chain packing mode, in comparison with the lamellar crystalline phase. The kinetic properties of the U phase were also studied in detail, and it was found that the phase acts as a precursor phase in the process of forming the most stable crystalline phase. This work deepens our understanding of lipid crystallization behavior, and is also a step forward towards a more detailed picture of the phase behavior of lipid mixtures composed of long-and short-chain lipids.

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Hybrid bicelles as a pH-sensitive nanocarrier for hydrophobic drug delivery

Abstract: Stabilized disc-like hybrid bicelles provide pH-sensitive release, preferable cellular uptake, tumor accumulation and therapeutic effect in vitro and in vivo.

Cited by 32 publications

References 69 publications

Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications

Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications

Progress of Liposomal Nanohybrid Cerasomes as Novel Drug Nanocarriers

Phase behavior of a binary lipid system containing long- and short-chain phosphatidylcholines

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Hybrid bicelles as a pH-sensitive nanocarrier for hydrophobic drug delivery

Abstract: Stabilized disc-like hybrid bicelles provide pH-sensitive release, preferable cellular uptake, tumor accumulation and therapeutic effect in vitro and in vivo.

Cited by 32 publications

References 69 publications

Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications

Kinetically Stable Bicelles with Dilution Tolerance, Size Tunability, and Thermoresponsiveness for Drug Delivery Applications

&nbsp;Progress of Liposomal Nanohybrid Cerasomes as Novel Drug Nanocarriers

Phase behavior of a binary lipid system containing long- and short-chain phosphatidylcholines

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Progress of Liposomal Nanohybrid Cerasomes as Novel Drug Nanocarriers