“…Genetic algorithms are able to solve optimization problems containing non-differentiable objective functions thought the global optimum is not guaranteed (Castell et al, 1998;Martens, 2004;Mavridou and Pardalos, 1997;Wu et al, 2007). In addition, simulated annealing has been applied in the layout of manufacturing systems (Balakrishnan et al, 2003;McKendall and Shang, 2006 The models to solve the layout problems cited above did not directly include safety issues. A new trend in designing plant layouts for the process industry consists of extending the layout formulations with safety issues.…”