Hyaluronidase as an Adjuvant in Bupivacaine-Lidocaine Mixture for Retrobulbar/Peribulbar Block

Kallio, H.; Paloheimo, Markku; Maunuksela, Eeva‐Liisa

doi:10.1097/00000539-200010000-00031

Cited by 73 publications

(40 citation statements)

References 15 publications

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“…A beneficial effect has been recorded with doses of 3.75-300 IU/ml, whereas others have been unable to demonstrate a difference with doses of 0.75-150 IU/ml. [3][4][5][6][7] Some of this discrepancy may relate to differences in the technique, differences in the type and volume of injected local anaesthetic, and problems with the assessment of akinesia.…”

Section: Introductionmentioning

confidence: 99%

The effect of hyaluronidase on ultrasound-measured dispersal of local anaesthetic following sub-Tenon injection

Khandwala

Ahmed

Goel

et al. 2007

Eye

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Purpose To determine by B-scan ultrasonography if the addition of hyaluronidase affects the dispersal of anaesthetic fluid after sub-Tenon's injection. Design Single-centre prospective randomised double-blind study. Materials and methods We performed a trial in 19 patients who were randomised to receive 5 ml of lidocaine 2% alone, or with hyaluronidase 15 IU/ml. A pre-anaesthetic B-scan ultrasound was performed followed by a standard infero-nasal sub-Tenon's injection. Further B-scan ultrasound studies were performed at 1, 3, and 5 min recording depth of local anaesthetic fluid. Data was analysed with Fisher's exact test and Student's t-test where appropriate. Results were considered significant when Po0.05. Results The maximum depth of local anaesthetic was significantly less in the hyaluronidase group than the control group at 3 and 5 min (0.79 vs 1.65 mm, P-value 0.01 and 0.43 vs 1.52 mm, P-value 0.002 respectively). There were no statistically significant differences in the akinesia, pain and surgical satisfaction scores between the two groups. Conclusions The addition of hyaluronidase significantly augments the dispersal of local anaesthetic fluid, as measured by B-scan ultrasonography.

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Section: Introductionmentioning

confidence: 99%

The effect of hyaluronidase on ultrasound-measured dispersal of local anaesthetic following sub-Tenon injection

Khandwala

Ahmed

Goel

et al. 2007

Eye

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show abstract

“…This also increases the frequency of complications such as globe perforation and hemorrhage [4]. To prevent this and to increase tissue diffusion, hyaluronidase and other adjutants such as clonidine, epinephrine and alkalinization were used to improve peribulbar block [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Dexmedetomidine vs. Magnesium Sulphate as an Adjuvant to Rocuronium Bromide, and Local Anaesthetic Mixture in Peribulbar Anaesthesia for Viteroretinal Surgery

Mogahed¹,

Nassar²,

Abdullah³

2017

J Anesth Clin Res

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“…In order to avail these properties, adjuvants have been used with local anesthetics [4][5][6][7][8][9] or local anesthetics with different properties have been combined 10 . Ropivacaine, due to its weaker motor block effect, has become popular for obstetric anesthesia and analgesia in the last two decades.…”

Section: Introductionmentioning

confidence: 99%

Ropivacaína, articaína ou combinação de ropivacaína e articaína em anestesia peridural para cesariana: estudo randomizado, prospectivo e duplo-cego

Yurtlu¹,

Kaya²

2013

Rev. Bras. Anestesiol.

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Background and objectives: Initiation of epidural anesthesia with long-lasting local anesthetics consumes a signifi cant amount of time, which could be problematic in busy obstetric anesthesia suites. We have hypothesized that a combination of articaine and ropivacaine provides faster onset and even an early recovery of sensory-motor block characteristics. Methods: Sixty term parturients scheduled to have elective cesarean section were randomly allocated into three groups to receive either 20 mL 2% articaine (Group A), 10 mL 2% articaine + 10 mL 0.75% ropivacaine (Group AR) or 20 mL 0.75% ropivacaine (Group R) via lumbar epidural catheter. The onset time of sensory block to T 10, T 6 and maximum sensory block level, time to two segments regression from maximum sensory block level, onset time and duration of motor block were all recorded. Intraoperative and postoperative additional analgesic requirements were also recorded. Results: Demographic data were similar. The onset times of sensorial block to T 10 and T 6 were signifi cantly shorter in Groups A and AR in comparison with Group R (p < 0.05). The onset times of motor block were similar in all groups, but a more intense motor block was observed in Group R (p < 0.05). Two segments regression time and motor block durations were signifi cantly shorter in Groups A and AR in comparison with Group R (p < 0.05). Intraoperative supplementary analgesic requirements were higher in Group A than in the other two groups (p < 0.05). Conclusion: A combination of 2% articaine and 0.75% ropivacaine for epidural anesthesia in a cesarean section should be preferred over epidural 0.75% ropivacaine alone.

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Hyaluronidase as an Adjuvant in Bupivacaine-Lidocaine Mixture for Retrobulbar/Peribulbar Block

Abstract: We conclude that the addition of hyaluronidase 3.75 or 7.5 IU/mL improved the success of the initial retrobulbar/peribulbar block and akinesia and reduced the need for supplementary block.

Cited by 73 publications

References 15 publications

The effect of hyaluronidase on ultrasound-measured dispersal of local anaesthetic following sub-Tenon injection

The effect of hyaluronidase on ultrasound-measured dispersal of local anaesthetic following sub-Tenon injection

Dexmedetomidine vs. Magnesium Sulphate as an Adjuvant to Rocuronium Bromide, and Local Anaesthetic Mixture in Peribulbar Anaesthesia for Viteroretinal Surgery

Ropivacaína, articaína ou combinação de ropivacaína e articaína em anestesia peridural para cesariana: estudo randomizado, prospectivo e duplo-cego

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