Hyaluronidase and degranulation inhibitors from the edible roots of <i>Oenanthe javanica</i> including seric acids F and G that were obtained by heating

Murata, Toshihiro; Katagiri, Tatsuo; Osaka, Mariko; Yamauchi, Shohei; Yoshimura, Kenshi; Kawada, Manami; Yu, Fang; Suzuki, Yuka; Sasaki, Kenroh

doi:10.1093/bbb/zbaa042

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Rosmarinic acid oligomers (trimer IC 50 = 275 µM; tetramer IC 50 = 183 µM) blocked Hyal more potent than rosmarinic acid (IC 50 = 309 µM). Activity against hyalurinidase is also shown by seric acid A (IC 50 = 119 µM), F (IC 50 = 1330 µM), and G (IC 50 = 1270 µM) isolated from the Oenanthe javanica root ( Figures 3 and 4 ) ( Table 4 ) 48 .…”

Section: Inhibitors Of Hyaluronidasementioning

confidence: 92%

Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship

Gębalski

Graczyk

Załuski

2022

Journal of Enzyme Inhibition and Medicinal Chemistry

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Human has used plants to treat many civilisation diseases for thousands of years. Examples include reserpine (hypertension therapy), digoxin (myocardial diseases), vinblastine and vincristine (cancers), and opioids (palliative treatment). Plants are a rich source of natural metabolites with multiple biological activities, and the use of modern approaches and tools allowed finally for more effective bioprospecting. The new phytochemicals are hyaluronidase (Hyal) inhibitors, which could serve as anti-cancer drugs, male contraceptives, and an antidote against venoms. In turn, tyrosinase inhibitors can be used in cosmetics/pharmaceuticals as whitening agents and to treat skin pigmentation disorders. However, the activity of these inhibitors is stricte dependent on their structure and the presence of the chemical groups, e.g. carbonyl or hydroxyl. This review aims to provide comprehensive and in-depth evidence related to the anti-tyrosinase and anti-Hyal activity of phytochemicals as well as confirming their efficiency and future perspectives.

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Section: Inhibitors Of Hyaluronidasementioning

confidence: 92%

Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship

Gębalski

Graczyk

Załuski

2022

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…[22][23][24] The β-hexosaminidase release assay has been used as an alternative to the histamine release assay in several studies. 25,26 β-Hexosaminidase release assays were performed to evaluate the degranulation inhibitory activity of the 2 compounds. Compounds 1 and 2 showed considerable degranulation inhibitory activity from 0.63 to 2.5 mM and 1.25 to 2.5 mM, respectively, in a concentration-dependent manner, without cytotoxicity (Figure 6A and B).…”

Section: Inhibitory Effect Of Compounds 1 and 2 On Degranulationmentioning

confidence: 99%

Isolation and Quantification of 2-O-Caffeoyl-hydroxycitric Acid, an Active Component in Hot Water Extracts of Coriander (Coriandrum sativum L.), Which Inhibits Degranulation of RBL-2H3 Cells

Ikeda,

Sugahara,

Kanamitsu

et al. 2023

Natural Product Communications

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Objectives: Natural compounds that can effectively prevent and alleviate allergic symptoms, such as hay fever, are widely sought after from sources such as natural ingredients that can be ingested daily. Coriander extracts have been reported to show anti-allergic activity; however, hot water extracts have not been tested previously. Here, we found that a hot water extract of the aerial parts of coriander inhibited the degranulation of rat basophilic leukemia cell line RBL-2H3 cells and identified the active compounds. Methods: Chromatographic methods were used to isolate compounds from the hot water extract of coriander. The chemical structures were elucidated by analyses of high-resolution electrospray ionization mass spectrum and nuclear magnetic resonance spectral data. The degranulation activity of compounds was evaluated using the β-hexosaminidase release assay. Results: We analyzed the components to identify active compounds. 2 S,3 S-2- O-caffeoyl-hydroxycitric acid (1), and 2- O-caffeoyl-hydroxycitric acid 6′- O-methyl ester (2) were isolated from the hot water extract of coriander, and both compounds showed degranulation inhibitory activity in RBL-2H3 cells at a concentration below 2.5 mM. The content of compound 1 in the freeze-dried coriander powder was calculated to be 2.0% via HPLC quantification. Conclusions: Compound 1 was considered to be the primary active contributor in the hot water extract of coriander.

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“…Hyaluronidase is an enzyme that degrades HA. Inhibitors of hyaluronidase are expected to control the amount of HA, and inhibition activities of this enzyme have been hypothesized to relate to anti-allergic activity [56,57]. Dracocephalum foetidum (Lamiaceae) is a herbal plant used to treat inflammatory conditions.…”

Section: Effects On Human and Animal Healthmentioning

confidence: 99%

Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans and livestock

Murata

Batkhuu

2021

J Nat Med

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Mongolian nomadic people possess traditional knowledge of wild plants that grow in their areas of habitation. Many of these are forage plants in nature and are consumed by livestock. However, these plants are known to have medicinal and/or toxic properties. To establish a scientific understanding of the plants, and in turn, offer sound knowledge on their applications and effective use, it is essential to collect data pertaining to the chemical constituents of each plant. Therefore, the first objective of this study was to identify and determine the structural constituents of the forage plants that were available to our research group. Furthermore, in an attempt to demonstrate the biological activities of the isolated chemical compounds, we focused on solving some of the social issues affecting Mongolian communities, including protozoan diseases affecting livestock, vectors of infectious diseases, and the general health of humans and their livestock. The results of the chemical constituents derived from Mongolian medicinal plants and their biological activities that were studied in the recent decade are also described herein. Graphic abstract

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Hyaluronidase and degranulation inhibitors from the edible roots of Oenanthe javanica including seric acids F and G that were obtained by heating

Cited by 5 publications

References 20 publications

Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship

Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship

Isolation and Quantification of 2-O-Caffeoyl-hydroxycitric Acid, an Active Component in Hot Water Extracts of Coriander (Coriandrum sativum L.), Which Inhibits Degranulation of RBL-2H3 Cells

Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans and livestock

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