Hyaluronidase administered with xylazine–tiletamine–zolazepam into adipose tissue shortens recovery from anesthesia in pigs

Bisetto, Shayne Pedrozo; Carregaro, Adriano Bonfim; Nicolai, André E.S.; Bressan, Thaís Feres; Leal, William P.; Xavier, Nathalia Villaça; Leal, Diego Feitosa; Andrade, André Furugen Cesar de

doi:10.1016/j.vaa.2016.09.003

Cited by 4 publications

(2 citation statements)

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“…Tiletamine is a competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist that exerts analgesia and immobilization, while zolazepam is a benzodiazepine drug for muscle relaxation and sedation [11][12][13]. Xylazine is an α2 receptor agonist for sedation, analgesia, and muscle relaxation [14].…”

Section: Introductionmentioning

confidence: 99%

Comparison of cardiorespiratory and anesthetic effects of ketamine-midazolam-xylazine-sufentanil and tiletamine-zolazepam-xylazine in miniature pigs

et al. 2022

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Effective and adequate anesthesia is conducive to better restrain for pigs during surgical or diagnostic procedures This study aimed to evaluate cardiorespiratory and anesthetic effects of ketamine-midazolam-xylazine-sufentanil or tiletamine-zolazepam-xylazine as general anesthetics in miniature pigs. In phase 1, one of the combinations was administered intramuscularly to miniature pigs. The KMXS protocol combined 10 mg kg-1 ketamine, 0.5 mg kg-1 midazolam, and 2 mg kg-1 xylazine with 2 μg kg-1 sufentanil. The TZX protocol combined 2.2 mg kg-1 tiletamine, 2.2 mg kg-1 zolazepam, and 1.4 mg kg-1 xylazine. After treatment, the mean arterial pressure, systolic arterial pressure, diastolic arterial pressure, heart rate, respiratory rate, peripheral hemoglobin oxygen saturation, rectal temperature, and anesthesia quality were recorded. In phase 2, the feasibility of KMXS and TZX as general anesthetics were evaluated for pig castration. In phase 1, both drug combinations provided smooth induction with similar anesthetic effects. The KMXS protocol provided moderate anesthesia for 60–70 minutes in pigs, while the TZX protocol provided 30–45 minutes. In phase 2, castration was completed smoothly in all pigs with little fluctuation in physiological variables. The KMXS protocol is better for medium-term anesthesia, while the TZX protocol is preferable for short-term anesthesia in pigs.

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Section: Introductionmentioning

confidence: 99%

Comparison of cardiorespiratory and anesthetic effects of ketamine-midazolam-xylazine-sufentanil and tiletamine-zolazepam-xylazine in miniature pigs

et al. 2022

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“…A xilazina e a detomidina são utilizadas principalmente para contenção química e como medicação pré-anestésica objetivando reduzir a dose de anestésicos gerais. A associação desses fármacos é feita com agentes dissociativos, tais como opioides, fenotiazinas, benzodiazepínicos, agentes inalatórios, butirofenonas e agentes anestésicos como o propofol (ALBUQUERQUE et al, 2016;SCHMITZ et al, 2016;BISETTO et al, 2017;RAJPUT et al, 2017). Uma vantagem no emprego desses α-2 adrenérgicos é a possibilidade da reversão de seus efeitos por antagonistas, como a ioimbina e o atipamezole (FAHLMAN et al, 2005;ALLAN, 2015;ESTERUELAS et al, 2017;JANSSEN et al, 2017…”

Section: 4-agonistas De Receptores Alfa-2 Adrenérgicosunclassified

Contenção química de tamanduá-bandeira (Myrmecophaga tridactyla Linnaeus, 1758) e tamanduá-mirim (Tamandua tetradactyla Linnaeus, 1758) com a associação de dois protocolos

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Injectable Anesthetics and Field Anesthesia

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2022

Farm Animal Anesthesia

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Hyaluronidase administered with xylazine–tiletamine–zolazepam into adipose tissue shortens recovery from anesthesia in pigs

Cited by 4 publications

References 9 publications

Comparison of cardiorespiratory and anesthetic effects of ketamine-midazolam-xylazine-sufentanil and tiletamine-zolazepam-xylazine in miniature pigs

Comparison of cardiorespiratory and anesthetic effects of ketamine-midazolam-xylazine-sufentanil and tiletamine-zolazepam-xylazine in miniature pigs

Contenção química de tamanduá-bandeira (Myrmecophaga tridactyla Linnaeus, 1758) e tamanduá-mirim (Tamandua tetradactyla Linnaeus, 1758) com a associação de dois protocolos

Injectable Anesthetics and Field Anesthesia

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