Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: II. In vivo

Williams, James M.; Plaza, Veronica; Hui, Francis; Wen, Catherine; Kuettner, Klaus E.; Homandberg, Gene A.

doi:10.1016/s1063-4584(97)80019-2

Cited by 62 publications

(27 citation statements)

References 22 publications

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“…Therefore the chain of events that, from fibronectin fragments, via cytokines, leads to a reduced synthesis of proteoglycans, is blocked (31)(32)(33)(34).…”

Section: Hyaluronic Acid and Its Therapeutic Usementioning

confidence: 99%

Viscosupplementation with Hyaluronic Acid in Hip Osteoarthritis (a review)

Abate¹,

Pelotti²,

Amicis³

et al. 2008

Upsala Journal of Medical Sciences

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Background: Viscosupplementation (VS) with hyaluronic acid (HA) is largely used for knee osteoarthritis therapy, but the evidences for its usefulness in hip osteoarthritis (OA) are limited. Methods: In this review, an extensive search of published trials on VS in hip OA was performed. From the selected papers the following data were extracted: sample size, inclusion / exclusion criteria, treatment procedures, evaluation methods, follow-up duration and clinical outcomes. Results: The level of evidence was low in quite all the trials (no placebo controlled groups). A reduction of pain and an improvement of function after 3 months, persistent in the long term (12 -18 months), was observed. Patients with mild morphological alterations responded better to therapy. Side effects were negligible, and were limited to pain and a sensation of heaviness in the injection site. No clear differences among Low (LMW) and High Molecular Weight (HMW) HA preparations were found in the clinical outcomes. However, for HMW-HA preparations, a lower number of injections was, in general, necessary in order to reach the therapeutic effect. Conclusions: Despite the initial promising results, some questions still remain open : 1) the characteristics of responders must be more precisely defined; 2) the treatment schedules, at present mainly based on the individual clinical experience, need a proper and accepted standardization. Finally, larger and placebo controlled trials are necessary to confirm the efficacy of VS in hip OA.

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“…Therefore the chain of events that, from fibronectin fragments, via cytokines, leads to a reduced synthesis of proteoglycans, is blocked (31)(32)(33)(34).…”

Section: Hyaluronic Acid and Its Therapeutic Usementioning

confidence: 99%

Viscosupplementation with Hyaluronic Acid in Hip Osteoarthritis (a review)

Abate¹,

Pelotti²,

Amicis³

et al. 2008

Upsala Journal of Medical Sciences

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“…Both the in vitro and in vivo Fn-f models have also been used to test the effects of high molecular weight hyaluronic acid (HA), a chondroprotective agent that has shown mixed clinical results as discussed (101,102). HA added to human knee (103) or bovine cartilage explants in vitro (101) partially blocked the effects of Fn-fs and partially promoted restoration of PG in Fn-f damaged cartilage.…”

Section: Both Have Been Used As Models Of Cartilage Degradationmentioning

confidence: 99%

“…Figure 6B illustrates that HA has the ability to restore PG in Fn-f damaged human knee explants. HA has also been shown to be effective in decreasing the matrix damaging activities of Fn-fs injected into rabbit knee joints (102). Thus, the in vivo model has provided a more relevant test system, while the in vitro model will allow us to investigate the mechanism for this reparative activity of HA.…”

Section: Both Have Been Used As Models Of Cartilage Degradationmentioning

confidence: 99%

Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments

Homandberg¹

1999

Front Biosci

102

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“…This dose is similar to the 0.1 ml/kg that were injected in rabbits or dogs in other studies. 17,18,28,29 However, the results were extremely heterogeneous. This may be due to several reasons, such as the degree of arthritis when the dose is initially injected, whether intra-articular injection of the medication was accomplished and whether the animal responded to the medication.…”

Section: Discussionmentioning

confidence: 99%

Experimental osteoarthritis model by means of medial meniscectomy in rats and effects of diacerein administration and hyaluronic acid injection

et al. 2014

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CONTEXT AND OBJECTIVE: The development of a slow and progressive mechanical model for osteoarthritis is important for correlation with clinical practice, and for evaluating the effects of disease-modifying medications. A mechanical osteoarthritis model was developed to evaluate the effects of intra-articular hyaluronic acid (HA) injection and oral diacerein administration. DESIGN AND SETTING: Experimental study at the Department of Orthopedics and Traumatology, Universidade de São Paulo. METHOD: Total medial meniscectomy was performed on seven groups of ten Wistar rats each, comprising four control groups (C) and three study groups (S). C.I: operated, non-medicated; C.II: operated, injections of HA vehicle; C.III: non-operated, non-medicated; C.IV: operated, non-medicated, sacrificed three months post-meniscectomy; S.I: operated, receiving intra-articular HA injections; S.II: operated, oral diacerein from the third to the seventh postoperative month; S.III: operated, received both medications. All the animals (except C.IV) were sacrificed seven months post-meniscectomy. All femurs and tibias were assessed histologically. RESULTS: The most severe degenerative histological changes were in the tibias of the operated knees. On the contralateral side, all groups had mild changes on the tibial surface. The femoral surface had slight changes. C.I showed severe changes. S.II results matched those of C.IV. HA protected the tibial surface. S.II and S.III had similar results. CONCLUSIONS: 1) The experimental model produced mild arthritis after three months and severe arthritis after seven months; 2) diacerein reduced the degenerative changes in both knees; 3) HA protected the joint cartilage; 4) Combining the two drugs did not improve the results.RESUMO CONTEXTO E OBJETIVO: Desenvolver um modelo osteoartrítico mecânico lento e progressivo é importante para correlação com a prática clínica e para avaliar os efeitos de medicamentos modificadores da doença. Um modelo mecânico de osteartrite foi desenvolvido para avaliar os efeitos de injeção intra-articular de hialuronato de sódio (AH) e de administração de diacereína oral. DESENHO E LOCAL: Estudo experimental no Departamento de Ortopedia e Traumatologia, Universidade de São Paulo. MÉTODO: Meniscectomia medial total foi feita em sete grupos de dez ratos Wistar, sendo quatro grupos controle (C) e três grupos estudo (E). C.I: operado, não medicado; C.II: operado, recebendo injeções do veículo do AH; C.III: não operado, não medicado; C.IV: operado, não medicado, sacrificado três meses pós-meniscectomia; EI: operado, recebendo injeções de AH intra-articular; E.II: operado, recebendo diacereína oral do terceiro ao sétimo mês pós-operatório; E.III: operado, recebeu ambas medicações. Todos os animais (exceto C.IV) foram sacrificados sete meses pós-meniscectomia. Todos os fêmures e tíbias foram analisados histologicamente. RESULTADOS: As alterações histológicas degenerativas mais graves encontram-se nas tíbias dos joelhos operados. No lado contra-lateral, todos os grupos apre...

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Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: II. In vivo

Cited by 62 publications

References 22 publications

Viscosupplementation with Hyaluronic Acid in Hip Osteoarthritis (a review)

Viscosupplementation with Hyaluronic Acid in Hip Osteoarthritis (a review)

Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments

Experimental osteoarthritis model by means of medial meniscectomy in rats and effects of diacerein administration and hyaluronic acid injection

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