Hyaluronic acid stimulates tumor-cell proliferation at wound sites

Effectiveness of Sodium Alginate as a Submucosal Injection Material for Endoscopic Mucosal Resection in Animal

“…Recently, it has been reported that sodium hyaluronate enhanced both tumor growth and CD44 expression of cancer cells at wound sites, suggesting that the use of sodium hyaluronate for EMR might stimulate the growth of residual tumor cells. 18 Alginates block co-polymers of L-guluronic and D-mannuronic acid residues connected by 1:4 glycosidic linkages. Therefore, we hypothesized that sodium alginate may be used as a submucosal injection for EMR considering its ability to form viscous solutions and gels.…”

Reed-Sternberg cell–derived lymphotoxin-α activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma

“…Hyaluronan, the only known nonsulfated glycosaminoglycan, is well known for involvement in wound healing, 44 tumor growth, 45,46 and adhesion/extravasation of activated lymphocytes. 47 Induction of hyaluronan on endothelial cells by proinflammatory cytokines, such as TNF-a and IL-1b, or by lipopolysaccharides is strictly restricted to microvascular endothelial cells.…”

Untitled

“…Finally, SH was compared to NS in a randomized controlled trial with gastric lesions proposed for ESD and it was shown that the usefulness rate and the volume of solution injected were significantly better in the 0.4 % SH group [18]. However, SH still faces some problems, namely its higher cost, requirement of an air-sealed container for storage, and the conflicting data concerning stimulation of tumor growth [36,37]. Sodium alginate is an inexpensive high viscosity solution.…”