Hyaluronic acid/serotonin-decorated cerium dioxide nanomedicine for targeted treatment of ulcerative colitis

Abstract

Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease often characterized by rapid progression and frequent comorbidities that make its treatment challenging. Myeloperoxidase (MPO) is a kind of heme...

Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress

“…MDA is a significant intermediate product of the oxidation of membrane lipids. It could exacerbate existing membrane injury, resulting in cytotoxicity, inflammatory response, and necrosis [ 45 , 46 ]. Nowadays, MDA levels are widely used as a means of evaluating the degree of tissue damage, the strength of lipid peroxidation, and the concentration of oxygen free radicals in various biological systems [ 47 ].…”

Advances in macrophage-targeting nanoparticles for the diagnosis and treatment of inflammatory bowel disease

“…Gao等 ［ 50 ］ 报道了一种透明质酸/5-羟色胺修饰的二氧化铈纳米酶，可以对溃疡性结肠炎的结肠溃疡中髓过氧化物酶和巨噬细胞CD44受体进行双重靶向，并利用静电作用消除病变部位活性氧，降低炎症因子水平，修复肠道上皮屏障。体外药代动力学实验和DSS诱导的C57BL/6小鼠结肠炎模型均验证了该二氧化铈纳米酶相比传统药物能更有效地减轻溃疡性结肠炎的肠道炎症，且比天然酶具备更好的稳定性、多功能性和可回收性 ［ 51 ］ 。…”

Catalytic investigation of hyaluronic acid-stabilized Ag nanoparticles as non-toxic nanocatalysts in the oxidation of morin

“…Carbohydrate polymers such as hyaluronic acid, chitosan, alginate, and cellulose are widely used as capping agents during the synthesis of AgNPs because these polymers are generally considered to be chemically stable, nontoxic, biocompatible, and biodegradable. 15,26–38 Among them, hyaluronic acid-capped AgNPs (HA-AgNPs) have attracted a great deal of attention due to their unique properties and have been studied in different research areas such as antibacterial coating, in vivo imaging, wastewater treatment, drug delivery, sensing, and cancer therapy. 39–48 Even though several research papers have been published on HA-AgNP-based bioactive materials, there are currently no reports on the catalytic investigation of HA-AgNPs as biocompatible and nontoxic catalysts in catalytic oxidation processes.…”