Hyaluronic acid production by irradiated human synovial fibroblasts

Yaron, Michael; Yaron, I; Levita, Moshe; Herzberg, M

doi:10.1002/art.1780200210

Cited by 10 publications

(9 citation statements)

References 11 publications

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“…The involvement of HA in the regulation of multiple cell functions, such as cell proliferation [13,14], migration [15], cytokine production [10, 16–18], and adhesion molecule expression [19], requires strict regulation of HA turnover. Degradation of HA or alteration of its synthesis and accumulation can be induced by various treatments, such as UV irradiation [20,21] or administration of 5‐fluorouracil (5‐FU) [22], hydrocortisone, or other chemicals [23]. A treatment‐induced alteration of the GAG composition in the bone marrow can significantly affect the function of the bone marrow microenvironment and, consequently, lead to an imbalance of hematopoietic homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Facilitates the Recovery of Hematopoiesis following 5‐Fluorouracil Administration

et al. 2004

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The fate of hematopoietic stem cells (HSCs) is determined by microenvironmental niches, but the molecular structure of these local networks is not yet completely characterized. Our recent observation that glycosaminoglycan hyaluronic acid (HA), a major component of the bone marrow extracellular matrix, is required for in vitro hematopoiesis led us to suggest a role for HA in structuring the hematopoietic niche. Accordingly, HA deprivation induced by various treatments might lead to an imbalance of normal HSC homeostasis. Since 5-fluorouracil (5-FU) administration sharply decreases the amount of cell surface-associated HA in bone marrow, we examined whether the administration of exogenous HA enhances suppressed hematopoiesis in 5-FU-treated mice. HA administered to mice following 5-FU infusion facilitated the recovery of leukocytes and thrombocytes in the peripheral blood. Intravenously infused HA was found in the bone marrow, where it bound endothelial cells and resident macrophages and increased expression of the hematopoiesis-supportive cytokines interleukin-1 and interleukin-6. In agreement with these observations, enhanced hematopoietic activity was detected in the bone marrow, as measured by elevated counts of long-term culture-initiating cells (LTC-ICs), committed progenitors, and the total number of mature bone marrow cells. Overall, our results suggest that HA is required for regulation of the hematopoiesis-supportive function of bone marrow accessory cells and, therefore, participates in hematopoietic niche assembly.

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Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Facilitates the Recovery of Hematopoiesis following 5‐Fluorouracil Administration

et al. 2004

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“…However, radiation is a rare cause that has not been frequently associated with mucinoses in the literature. Takeda et al recently published a case of follicular mucinosis associated with radiation therapy and mentioned in their discussion some previous investigations on how radiated fibroblasts increase the production of hyaluronic acid …”

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confidence: 99%

“…Takeda et al 2 recently published a case of follicular mucinosis associated with radiation therapy and mentioned in their discussion some previous investigations on how radiated fibroblasts increase the production of hyaluronic acid. 3 We present a case of localized papular mucinosis in an area of radiation therapy in a patient who had undergone an operation for a breast carcinoma.…”

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confidence: 99%

Papular mucinosis of the breast after radiation therapy

2014

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Localized papular mucinosis is a type of mucinosis induced by several different causes. However, to the best of our knowledge, prior radiation therapy has not been reported to be related to papular mucinosis. We present a case of a 47-year-old woman who had undergone an operation for a breast carcinoma 2 years earlier and received local radiotherapy in the affected breast. Currently, she presents multiple erythematous papules that are caused by abundant dermal mucin deposits. We discuss some potential differential diagnoses.

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“…The long term value of synovectomy in patients with rheumatoid arthritis is not clear, but the short term clinical response appears to be of benefit whether this is from surgery (17-2 1) or from injections of radionuclides Irradiation with 2,000 rads of human synovium grown in tissue culture actually stimulates the production of hyaluronic acid production while only creating minimal inhibition of cell growth (22). This suggests that the beneficial results which occur from local irradiation are due to effects on non-synovial cells such as the inflammatory cells.…”

Section: Discussionmentioning

confidence: 99%

Total lymphoid and local joint irradiation in the treatment of adjuvant arthritis

Schurman

Hirshman

Strober

1981

Arthritis & Rheumatism

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Total lymphoid irradiation (TLI) with 3,400 rads delivered in 17 divided doses, 600 rads at local paw irradiation in 3 divided doses, or both TLI and local irradiation were used to treat Lewis rats with adjuvant arthritis. Either TLI alone or local paw irradiation modestly reduced the severity of arthritis compared to a control group (P < 0.05). TLI treated animals had more initial suppression of inflammation. Adjuvant rats treated with a combination of both TLI and local paw irradiation had a profound and long lasting reduction in inflammation and permanent arthritis (P < 0.001).Immunosuppression in one form or another is well known to be beneficial in the treatment of inflammatory polyarthropathies. The lymphocyte is integrally involved in the histopathology of all forms of inflammatory arthritis in humans and animals. Alkylating agents which are known to destroy lymphocytes and thoracic duct drainage which mechanically depletes lymphocytes are associated with a decrease in synovitis in patients with rheumatoid arthritis (1). We reasoned, therefore, that the technique of selective irradiation (TLI) used to treat Hodgkin's disease might prove to be a valuable treatment for inflammatory synovitis since this regimen produces long lasting immunosuppression and T lymphocytopenia (2). Local irradiation of pigmented villonodular synovitis and intraarticular injection of radionuclides have met with some success as alternatives to surgical synovectomy (3-5). We investigated how local irradiation of inflamed joints would compare to TLI in suppressing inflammatory arthiritis in an animal model. This report describes the results of TLI and local joint irradiation separately and in combination in adjuvant arthritis of rats. It was found that either TLI or local joint irradiation is therapeutic by itself, but the combination of both modalities is substantially more effective than either alone. MATERIALS AND METHODSExperimental scheme. Adult inbred Lewis rats weighing 350 to 500 gm were injected with 1.0 mg of Mycobacterium butyricum suspended in medium grade oil at a concentration of 10 mg/ml in the subcutaneous aspect of the left hind paw (LHP), in a procedure similar to that reported by Chang (6). On the seventeenth day after inoculation of the LHP, animals that developed arthritis in one or more of the remaining three paws and had a minimum arthritis rating score of three (see "Scoring of joints") were divided into four groups of approximately 4 animals each. Groups were chosen so that there was a similar distribution of arthritis, and the average score of each group was similar at the start. All treatment regimens started on the seventeenth day after adjuvant inoculation. One group served as controls and received no irradiation. A second group was given a total of 3,400 rads of TLI in divided doses of 200 rads/day on a 5-day-a-week basis over a period of 24 days. A third group of animals received both 3,400 rads of TLI and 600 rads to each of the four paws. The paws were irradiated with 200 rads/day for 3 days starting ...

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Hyaluronic acid production by irradiated human synovial fibroblasts

Cited by 10 publications

References 11 publications

Hyaluronic Acid Facilitates the Recovery of Hematopoiesis following 5‐Fluorouracil Administration

Hyaluronic Acid Facilitates the Recovery of Hematopoiesis following 5‐Fluorouracil Administration

Papular mucinosis of the breast after radiation therapy

Total lymphoid and local joint irradiation in the treatment of adjuvant arthritis

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