Abstract:Pleural empyema is an inflammatory condition characterized by 35 accumulation of pus inside the pleural cavity, which is usually followed by bacterial pneumonia. During the disease process, the pro-inflammatory and pro-fibrotic cytokines in the purulent pleural effusion cause proliferation of fibroblasts and deposition of extracellular matrix, which lead to fibrin deposition and fibrothorax.Urokinase instillation therapy through a chest drainage tube is frequently used for 40 fibrinolysis in patients with empy… Show more
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