Hyaluronic Acid Nanoparticles as Nanomedicine for Treatment of Inflammatory Diseases

Rao, N. Vijayakameswara; Rho, Jun Gi; Um, Wooram; Ek, Pramod Kumar; Nguyen, Van Quy; Oh, Bong Ryoul; Kim, Wook; Park, Jae Hyung

doi:10.3390/pharmaceutics12100931

Cited by 38 publications

(24 citation statements)

References 124 publications

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“…Thus, it is well established that blood and lymphatic transport system are responsible for HA distribution in the body [ 168 , 169 ]. The utilization of isotopes showed that high molecular weight HA (HMWHA) mainly accumulates in the liver, while LMWHA is secreted in urine [ 170 ]. Notably, many studies indicate that the differences in HA-based nanoparticles’ targeting efficiency depend on their molecular weight.…”

Section: Types Of Nanoparticles and Materials Utilized For Targetementioning

confidence: 99%

Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy

et al. 2021

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The tumor microenvironment (TME) is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded by the components of the extracellular matrix (ECM). Glycosaminoglycans (GAGs), natural biomacromolecules, essential ECM, and cell membrane components are extensively altered in cancer tissues. During disease progression, the GAG fine structure changes in a manner associated with disease evolution. Thus, changes in the GAG sulfation pattern are immediately correlated to malignant transformation. Their molecular weight, distribution, composition, and fine modifications, including sulfation, exhibit distinct alterations during cancer development. GAGs and GAG-based molecules, due to their unique properties, are suggested as promising effectors for anticancer therapy. Considering their participation in tumorigenesis, their utilization in drug development has been the focus of both industry and academic research efforts. These efforts have been developing in two main directions; (i) utilizing GAGs as targets of therapeutic strategies and (ii) employing GAGs specificity and excellent physicochemical properties for targeted delivery of cancer therapeutics. This review will comprehensively discuss recent developments and the broad potential of GAG utilization for cancer therapy.

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Section: Types Of Nanoparticles and Materials Utilized For Targetementioning

confidence: 99%

Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy

et al. 2021

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“…As stromal components, extracellular matrices (ECMs) such as collagen fibers, and high interstitial pressure would restrict the diffusion of nanoparticles in tumor tissues; then, the use of digestive enzymes such as collagenase and hyaluronidase has been investigated to improve nanoparticle delivery and gene transfer efficiency [ 268 , 269 , 270 , 271 ]. For active targeting to tumor, several ligands such as arginine-glycine-aspartate (RGD) peptide [ 272 ], HER-2-targeting peptide [ 273 ] and hyaluronic acid [ 274 ] have been used for nanoparticle delivery, and are promising for delivery of nucleic acid and gene medicines [ 275 , 276 ]. Targeting tumor-associated macrophages (TAMs) in the tumor microenvironment is also a useful strategy to combat tumors [ 277 ].…”

Section: Rational Designmentioning

confidence: 99%

Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs

et al. 2021

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Nucleic acid and genetic medicines are increasingly being developed, owing to their potential to treat a variety of intractable diseases. A comprehensive understanding of the in vivo fate of these agents is vital for the rational design, discovery, and fast and straightforward development of the drugs. In case of intravascular administration of nucleic acids and genetic medicines, interaction with blood components, especially plasma proteins, is unavoidable. However, on the flip side, such interaction can be utilized wisely to manipulate the pharmacokinetics of the agents. In other words, plasma protein binding can help in suppressing the elimination of nucleic acids from the blood stream and deliver naked oligonucleotides and gene carriers into target cells. To control the distribution of these agents in the body, the ligand conjugation method is widely applied. It is also important to understand intracellular localization. In this context, endocytosis pathway, endosomal escape, and nuclear transport should be considered and discussed. Encapsulated nucleic acids and genes must be dissociated from the carriers to exert their activity. In this review, we summarize the in vivo fate of nucleic acid and gene medicines and provide guidelines for the rational design of drugs.

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“…Another approach to achieve active drug targeting is the incorporation of hyaluronic acid (HA) into nanoparticle systems. HA is a negatively charged, non-sulfated glycosaminoglycan composed of repeating units of D-glucuronic acid and N-acetyl-D-glucosamine bound by beta-linkages and is found throughout the body in the extracellular matrix and synovial fluids [24]. HA-based nanoparticles have been extensively explored as delivery devices in cancer therapy by virtue of their ability to specifically bind CD44 receptor overexpressed on various cancer cells [25].…”

Section: Introductionmentioning

confidence: 99%

Dual-Targeted Hyaluronic Acid/Albumin Micelle-Like Nanoparticles for the Vectorization of Doxorubicin

et al. 2021

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Drug targeting of tumor cells is one of the great challenges in cancer therapy; nanoparticles based on natural polymers represent valuable tools to achieve this aim. The ability to respond to environmental signals from the pathological site (e.g., altered redox potential), together with the specific interaction with membrane receptors overexpressed on cancer cells membrane (e.g., CD44 receptors), represent the main features of actively targeted nanoparticles. In this work, redox-responsive micelle-like nanoparticles were prepared by self-assembling of a hyaluronic acid–human serum albumin conjugate containing cystamine moieties acting as a functional spacer. The conjugation procedure consisted of a reductive amination step of hyaluronic acid followed by condensation with albumin. After self-assembling, nanoparticles with a mean size of 70 nm and able to be destabilized in reducing media were obtained. Doxorubicin-loaded nanoparticles modulated drug release rate in response to different redox conditions. Finally, the viability and uptake experiments on healthy (BALB-3T3) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a drug vector in cancer therapy.

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Hyaluronic Acid Nanoparticles as Nanomedicine for Treatment of Inflammatory Diseases

Cited by 38 publications

References 124 publications

Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy

Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy

Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs

Dual-Targeted Hyaluronic Acid/Albumin Micelle-Like Nanoparticles for the Vectorization of Doxorubicin

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