Hyaluronic acid nanofibers crosslinked with a nontoxic reagent

Xue, Fuxin; Zhang, Hui; Hu, Junli; Liu, Yichun

doi:10.1016/j.carbpol.2021.117757

Cited by 16 publications

(5 citation statements)

References 33 publications

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“…The last case to discuss is the HA Ox -DA conjugate, again by comparing its 13 C ss-NMR spectrum with the reference spectra of DA•HCl and HA Ox (see Figure 3). Before proceeding to the analysis, it is important to first draw attention to a misconception that tends to be perpetuated in the recent literature regarding the structure of NaIO 4 oxidized hyaluronic acid [14,18,[21][22][23][24]. It has been claimed in several works that HA oxidation leads to ring opening of the glucoronic acid monomer and the formation of dialdehydes at the bond cleavage sites.…”

Section: Resultsmentioning

confidence: 99%

What Is Wrong with Hyaluronic Acid Chemistry? A 15N/13C Solid-State NMR Re-Evaluation of Its Dopamine Conjugates

et al. 2023

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In this work, a systematic 15N/13C solid-state NMR investigation is performed on three dopamine (DA) conjugates of hyaluronic acid, considered in both its native (HA) and NaIO4-oxidized (HAOx) forms. Two of them, here named HAEDC-DA and HAOx-DA, have been previously introduced as covalent conjugates involving DA amine nitrogen: the former by EDC-mediated amide bond formation, and the latter by reaction of the Schiff base with the aldehyde moieties presumed to exist in HAOx. The third conjugate, HA-DA, is reported here for the first time; it is obtained by simply mixing hyaluronan with DA∙HCl at pH 5. The 15N ss-NMR spectra were found to be consistent in all the systems, and the DA molecules were found to be in their charged -NH3+ form, which contradicts the HAEDC-DA/HAOx-DA covalent bonding schemes proposed in the literature. The 13C ss-NMR results add useful new insights into the structure and interaction patterns of the conjugates. All of our findings are relevant for future practical applications, for instance in developing novel HA-based hydrogels. In addition, the present study demonstrates the importance of using the most appropriate analytical tools when investigating composite systems due to the complexity of hyaluronic acid conjugates. Solid-state NMR proved essential to answering the question in the title: actually, there is nothing wrong with hyaluronic acid chemistry; the claimed covalent bonds between DA and the HA(HAOx) chain do not exist in these systems, because the conditions for their formation do not hold in practice.

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Section: Resultsmentioning

confidence: 99%

What Is Wrong with Hyaluronic Acid Chemistry? A 15N/13C Solid-State NMR Re-Evaluation of Its Dopamine Conjugates

et al. 2023

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“…The main components of synovial fluid include hyaluronic acid (HA), polyproteoglycans, and lubricin (Figure 4) [21]. HA is a high-molecular-weight linear polysaccharide that can bind many water molecules and separate the cartilage on both sides of the joint during sliding, which is essential for increasing synovial fluid viscosity [22]. At the same time, HA binds to phospholipids to anchor to the vesicle surface, and the combination of the two dramatically improves the hydration properties of synovial fluid.…”

Section: Surface Chemistry-dominated Frictionmentioning

confidence: 99%

Bioinspired Interfacial Friction Control: From Chemistry to Structures to Mechanics

Kong,

Ma,

Zhou

2024

Biomimetics

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Organisms in nature have evolved a variety of surfaces with different tribological properties to adapt to the environment. By studying, understanding, and summarizing the friction and lubrication regulation phenomena of typical surfaces in nature, researchers have proposed various biomimetic friction regulation theories and methods to guide the development of new lubrication materials and lubrication systems. The design strategies for biomimetic friction/lubrication materials and systems mainly include the chemistry, surface structure, and mechanics. With the deepening understanding of the mechanism of biomimetic lubrication and the increasing application requirements, the design strategy of multi-strategy coupling has gradually become the center of attention for researchers. This paper focuses on the interfacial chemistry, surface structure, and surface mechanics of a single regulatory strategy and multi-strategy coupling approach. Based on the common biological friction regulation mechanism in nature, this paper reviews the research progress on biomimetic friction/lubrication materials in recent years, discusses and analyzes the single and coupled design strategies as well as their advantages and disadvantages, and describes the design concepts, working mechanisms, application prospects, and current problems of such materials. Finally, the development direction of biomimetic friction lubrication materials is prospected.

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“…The strength of borate-chelated polysaccharide adhesive must be enhanced [105]. In recent years, the periodate oxidation-adipic acid dihydrazide cross-linking technique has been applied successfully to the development of robust polysaccharide-based composites, such as cellulose, starch, and pectin [106]. Also, periodate oxidation-adipic acid dihydrazide is environmentally friendly, and the cross-linked polysaccharide material exhibits outstanding biocompatibility and mechanical strength [107].…”

Section: Bio-based Cross-linking Agent Sourcesmentioning

confidence: 99%

A Review of Strategies to Enhance the Water Resistance of Green Wood Adhesives Produced from Sustainable Protein Sources

Oni,

Lawrence,

Zappi

et al. 2023

Sustainability

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The health risks associated with formaldehyde have propelled relevant stakeholders to push for the production of non-toxic wood adhesives. Several countries including the USA, Japan, and Germany have implemented policies mandating manufacturers to reduce the emissions of formaldehyde to lower levels. Protein adhesives stand out due to their sustainability, renewable sources, and biodegradability. However, they are limited by poor wet strength and water resistance, which affect their wide acceptability in the marketplace. Researchers have developed multiple strategies to mitigate these issues to advance protein adhesives so they may compete more favorably with their petroleum-based counterparts. This review paper explores these strategies including cross-linking, modified fillers, and the removal of hydrophilic content while providing insights into the methodological approaches utilized in recent literature with a comparison of the resultant protein adhesives.

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Hyaluronic acid nanofibers crosslinked with a nontoxic reagent

Cited by 16 publications

References 33 publications

What Is Wrong with Hyaluronic Acid Chemistry? A 15N/13C Solid-State NMR Re-Evaluation of Its Dopamine Conjugates

What Is Wrong with Hyaluronic Acid Chemistry? A 15N/13C Solid-State NMR Re-Evaluation of Its Dopamine Conjugates

Bioinspired Interfacial Friction Control: From Chemistry to Structures to Mechanics

A Review of Strategies to Enhance the Water Resistance of Green Wood Adhesives Produced from Sustainable Protein Sources

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