Hyaluronic acid-modified [19F]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs

Yasakçı, Volkan; Tekin, Volkan; Guldu, Ozge Kozgus; Evren, Vedat; Ünak, Perıhan

doi:10.1007/s10967-018-6282-6

Cited by 8 publications

(6 citation statements)

References 55 publications

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“…Our results agree with previous data presented in the literature. [ 22,26 ] However, the size of nanocomposites in this study was larger than that in our previous studies in which Fe 3 O 4 @TiO 2 core nanoparticles were radiolabeled with 89 Zr, due to silication and conjugation with lupulones instead of 89 Zr. [ 8 ]…”

Section: Resultsmentioning

confidence: 59%

“…To increase the anticancer potential of Fe 3 O 4 @TiO 2 nanocomposites, the lupulone derivates-hexahydro lupulone (HLP) and ALP-were combined with the 5 mg ml À1 Fe 3 O 4 @TiO 2 nanocomposite in ethanol at room temperature and stirred after the addition of 50 mM of N-hydroxysuccinimide in an orbital shaker for 2 h. [22] 2.5 | Characterization of synthesized Fe 3 O 4 @TiO 2 nanocomposites…”

Section: Synthesis Of Lupulone-conjugated Fe 3 O 4 @Tio 2 Nanocompositesmentioning

confidence: 99%

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Synthesis and morphological studies of Tc‐99m‐labeled lupulone‐conjugated Fe₃O₄@TiO₂ nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines

Tutun

Tekin

Yasakçı

et al. 2021

Applied Organom Chemis

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The purpose of this study was to develop a multifunctional theranostic probe for imaging (magnetic resonance imaging [MRI] and single‐photon emission computed tomography [SPECT]) and therapy (photodynamic therapy). For this purpose, Tc‐99m‐labeled lupulone‐conjugated Fe3O4@TiO2 nanocomposites (99mTc‐DTPA‐Fe3O4@TiO2‐HLP and 99mTc‐DTPA‐Fe3O4@TiO2‐ALP nanocomposites) were synthesized. The average diameter of the nanocomposites was 171 ± 20 nm as seen on transmission electron microscopy images. Fe3O4@TiO2 nanocomposites exhibited fluorescence spectra at an emission wavelength of 314 nm. Lupulone‐conjugated Fe3O4@TiO2 nanocomposites were spherical‐shaped with a suitable dispersion and without visible aggregation, and their radiolabeling yields were over 85%. Healthy (RWPE‐1 normal human prostate epithelial cell line) and cancer prostate cell lines (PC‐3 human prostate cancer cell line) were used to determine the in vitro biological behavior of the nanocomposites. The PC‐3 cells treated with lupulone‐conjugated Fe3O4@TiO2 nanocomposites showed a lower cell viability compared with RWPE‐1 cells treated with lupulone‐conjugated Fe3O4@TiO2 nanocomposites. Lupulone‐modified Fe3O4@TiO2 nanocomposites may serve in the future as a multifunctional probe for positron emission tomography (PET)/MRI, photodynamic therapy, and hyperthermia therapy of cancer.

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Section: Resultsmentioning

confidence: 59%

Section: Synthesis Of Lupulone-conjugated Fe 3 O 4 @Tio 2 Nanocompositesmentioning

confidence: 99%

Synthesis and morphological studies of Tc‐99m‐labeled lupulone‐conjugated Fe₃O₄@TiO₂ nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines

Tutun

Tekin

Yasakçı

et al. 2021

Applied Organom Chemis

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“…The obtained samples were also characterized by FTIR (Figure 4). The peak observed at wave number 550 cm -1 for C-Fe3O4 was related to Fe-O bond [37]. The peak at 1071 cm -1 belongs to the Si-O stretch band.…”

Section: Nanoconjugatementioning

confidence: 94%

Multimodal Radiobioconjugates of Magnetic Nanoparticles Labeled with <sup>44</sup>Sc and <sup>47</sup>Sc for Theranostic Application

Ünak¹,

Yasakçı²,

Tutun³

et al. 2023

Preprint

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This study was performed to synthesize multimodal radiopharmaceutical designed for the diagnosis and treatment of prostate cancer. To achieve this goal, Super Paramagnetic Iron Oxide (SPIO) nanoparticles were used as a platform for targeting molecule (PSMA-617) and for complexation of two scandium radionuclides, 44Sc for PET imaging and 47Sc for radionuclide therapy. TEM and XPS images showed that the Fe3O4 NPs have a uniform cubic shape and a diameter from 38 to 50 nm. The Fe3O4 core are surrounded by SiO2 and an organic layer. The saturation magnetization of the SPION core was 60 emu/g. However, coating the SPIONs with silica and polyglycerol reduces the magnetization significantly. The obtained bioconjugates were labeled with 44Sc and 47Sc, with a yield higher than 97%. The radiobioconjugate exhibited high affinity and cytotoxicity towards the human prostate cancer LNCaP (PSMA+) cell line, much higher than for PC-3 (PSMA-) cells. High cytotoxicity of the radiobioconjugate was confirmed by radiotoxicity studies on LNCaP 3D-spheroids. In addition, the magnetic properties of the radiobioconjugate should allow for its use in guide drug delivery driven by magnetic field gradient.

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“…The modified mNPs were conjugated with nonradiactive F using NaF. mNPs and FDG-mNPs characterized similarly as described in our previous reports [10,14,15,16]. Briefly, the hydrodynamic diameter of mNPs or FDG-mNPs was measured using DLS.…”

Section: Synthesis and Characterization Of Fdg-mnpsmentioning

confidence: 99%

“…The conjugation of mNPs with the glucose analogue fluorodeoxyglucose (FDG) is thought to improve mNP cellular "incorporation and cytotoxicity in cancer cell lines. It is well known that cancer cells have a great affinity for glucose uptake due to the Warburg effect [8,9], and FDG is a glucose analogue that is rapidly taken up by cancer cells [7,10]. Meanwhile, metal and magnetic nanoparticles themselves induce apoptosis in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Ünak

Budiyo

Horsnzky

et al. 2021

Asian J. Nanosci. Mater.

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We present a report regarding the cytotoxic effects of iron-based magnetic nanoparticles conjugated with fluorodeoxyglucose (FDG-mNPs) on the viability of NCI-H727 and SH-SY5Y cancer cells. MTT assays were performed to determine cell viability in treated cancer cells grown under standard 2D culture conditions. FDG-mNP concentrations of 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL decreased mean cell viability of NCI-H727 cells to 92.5%, 82.9%, and 75% respectively. FDG-mNPs was also shown to have a detrimental effect on the viability of SY5Y cells: a decrease of 5.7%, 18.6%, and 36.4% was found for SY5Y cells treated with 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL concentrations of FDG-mNPs, respectively. When NCI-H727 and SH-SY5Y cancer cells were grown as 3D spheroids, morphology was visibly changed and the number of viable cells was decerased in spheroids treated with FDG-mNPs compared with untreated spheroids. The results of our study demonstrated that FDG-mNP has toxic effects on NCI-H7272 and SY5Y cancer cells, and we conclude that conjugated FDG-mNPs are promising in the development of clinical applications for the destruction of cancer cells.

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Hyaluronic acid-modified [19F]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs

Cited by 8 publications

References 55 publications

Synthesis and morphological studies of Tc‐99m‐labeled lupulone‐conjugated Fe₃O₄@TiO₂ nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines

Synthesis and morphological studies of Tc‐99m‐labeled lupulone‐conjugated Fe₃O₄@TiO₂ nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines

Multimodal Radiobioconjugates of Magnetic Nanoparticles Labeled with <sup>44</sup>Sc and <sup>47</sup>Sc for Theranostic Application

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Hyaluronic acid-modified [19F]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs

Cited by 8 publications

References 55 publications

Synthesis and morphological studies of Tc‐99m‐labeled lupulone‐conjugated Fe3O4@TiO2 nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines

Synthesis and morphological studies of Tc‐99m‐labeled lupulone‐conjugated Fe3O4@TiO2 nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines

Multimodal Radiobioconjugates of Magnetic Nanoparticles Labeled with <sup>44</sup>Sc and <sup>47</sup>Sc for Theranostic Application

Untitled

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Synthesis and morphological studies of Tc‐99m‐labeled lupulone‐conjugated Fe₃O₄@TiO₂ nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines

Synthesis and morphological studies of Tc‐99m‐labeled lupulone‐conjugated Fe₃O₄@TiO₂ nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines