Hyaluronic acid-methacrylic anhydride/polyhexamethylene biguanide hybrid hydrogel with antibacterial and proangiogenic functions for diabetic wound repair

Li, Yike; Zheng, Huiyu; Liang, Yaxian; Xuan, Ming; Liu, Guiting; Xie, Huixu

doi:10.1016/j.cclet.2022.03.116

Cited by 33 publications

(13 citation statements)

References 21 publications

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“…Coincidently, Li and colleagues reported a similar PHMB-loaded hybrid hydrogel using hyaluronic acid chemically modified by methacrylic anhydride for diabetic wound repair. 163 This hybrid hydrogel displayed promoted granulation of tissue and subcutaneous capillary formation, more collagen deposition, and better wound healing.…”

Section: Reviewmentioning

confidence: 99%

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

Wang,

Hu,

Chiou

et al. 2023

Polym. Chem.

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Section: Reviewmentioning

confidence: 99%

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

Wang,

Hu,

Chiou

et al. 2023

Polym. Chem.

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“…These properties can support hydrogels as excellent carriers for inducing cell proliferation or differentiation and internal environment homeostasis in endometrial injury. [300][301][302] Hydrogels have recently found extensive application in bone repair, 303 cardiovascular scaffolds, 304 vascular regeneration, [305][306][307] and skin excipients. 308 The exceptional properties of hydrogels enable them to serve as carriers for estrogens, active substances, drugs, and stem cells, facilitating their transportation into the uterine cavity.…”

Section: Requirements Of Biomedical Hydrogelsmentioning

confidence: 99%

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Hu,

Wu,

Yong

et al. 2023

MedComm

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The endometrium is a unique human tissue with an extraordinary ability to undergo a hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and regeneration throughout the female reproductive cycle. The cyclical repair and regeneration of the endometrium manifest as changes in endometrial epithelialization, glandular regeneration, and vascularization. The mechanisms encompass inflammation, coagulation, and fibrinolytic system balance. However, specific conditions such as endometriosis or TCRA treatment can disrupt the process of cyclical endometrial repair and regeneration. There is uncertainty about traditional clinical treatments' efficacy and side effects, and finding new therapeutic interventions is essential. Researchers have made substantial progress in the perspective of regenerative medicine toward maintaining cyclical endometrial repair and regeneration in recent years. Such progress encompasses the integration of biomaterials, tissue‐engineered scaffolds, stem cell therapies, and 3D printing. This review analyzes the mechanisms, diseases, and interventions associated with cyclical endometrial repair and regeneration. The review discusses the advantages and disadvantages of the regenerative interventions currently employed in clinical practice. Additionally, it highlights the significant advantages of regenerative medicine in this domain. Finally, we review stem cells and biologics among the available interventions in regenerative medicine, providing insights into future therapeutic strategies.

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“…Consequently, addressing these issues are currently main hurdles for the paracrine system. A 3D hydrogel cell medium allowed more intercellular and cell–matrix interactions in contrast to a 2D cell culture and was closer to a physiological condition [ 22 , 23 , 24 , 25 ]. It was reported that metabolic level, cellular stress response, cellular signal transduction together with the protein transportation level in 3D cell culture was higher than that of in a 2D cell culture [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Performance Evaluation of Gelatin/Sodium Alginate Hydrogel-Based Macrophage and MSC Cell-Encapsulated Paracrine System with Potential Application in Wound Healing

Hui-yuan

Yuan

et al. 2023

IJMS

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A gelatin/sodium alginate-based hydrogel microsphere has been fabricated after reaction condition optimization. Macrophages (RAW246.7) and adipose mesenchymal stem cells (ADSC) have been subsequently encapsulated in the microsphere in order to construct a 3D paracrine system for wound healing treatment. The synthesized microsphere displayed neglectable cytotoxicity toward both encapsulated cells until 10 days of incubation, indicating promising biocompatibility of the microsphere. A qRT-PCR and ELISA experiment revealed positive regulation of cytokines (Arg-1, IL-6, IL-8, IL-10, bFGF, HGF, VEGF, TLR-1, and CXCL13) expression regarding macrophage phenotype transformation and anti-inflammatory performance both inside the microsphere and in the microenvironment of established in vitro inflammatory model. Additionally, positive tendency of cytokine expression benefit wound healing was more pronounced in a fabricated 3D paracrine system than that of a 2D paracrine system. Furthermore, the 3D paracrine system exhibited more efficiently in the wound healing rate compared to the 2D paracrine system in an in vitro model. These results suggested the current paracrine system could be potentially used as a robust wound healing dressing.

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Hyaluronic acid-methacrylic anhydride/polyhexamethylene biguanide hybrid hydrogel with antibacterial and proangiogenic functions for diabetic wound repair

Cited by 33 publications

References 21 publications

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Fabrication and Performance Evaluation of Gelatin/Sodium Alginate Hydrogel-Based Macrophage and MSC Cell-Encapsulated Paracrine System with Potential Application in Wound Healing

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