Hyaluronic acid-graphene oxide quantum dots nanoconjugate as dual purpose drug delivery and therapeutic agent in meta-inflammation

Sarkar, Kunal; Bank, Sarbashri; Chatterjee, Arindam; Dutta, Koushik; Das, A.; Chakraborty, Santanu; Paul, Nirvika; Sarkar, Jit; De, S. S.; Ghosh, Sudakshina; Acharyya, Kinsuk; Chattopadhyay, Dipankar; Das, Madhusudan

doi:10.1186/s12951-023-02015-w

Cited by 14 publications

(3 citation statements)

References 92 publications

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“…GOQDs are nanoscale derivatives of GO. They have been widely used in the field of biomedical science, such as biosensing, bioimaging, drug delivery, and photodynamic therapy [ 15 , 18 , 24 , 39 – 42 ]. Recently, the application potential of GOQDs in tissue engineering has attracted our attention.…”

Section: Discussionmentioning

confidence: 99%

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Human periodontal ligament stem cell sheets activated by graphene oxide quantum dots repair periodontal bone defects by promoting mitochondrial dynamics dependent osteogenic differentiation

An,

Yan,

Qiu

et al. 2024

J Nanobiotechnol

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Background Bone defects in the maxillofacial region restrict the integrity of dental function, posing challenges in clinical treatment. Bone tissue engineering (BTE) with stem cell implants is an effective method. Nanobiomaterials can effectively enhance the resistance of implanted stem cells to the harsh microenvironment of bone defect areas by promoting cell differentiation. Graphene oxide quantum dots (GOQDs) are zero-dimensional nanoscale derivatives of graphene oxide with excellent biological activity. In the present study, we aimed to explore the effects of GOQDs prepared by two methods (Y-GOQDs and B-GOQDs) on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs), as well as the effect of gelatin methacryloyl (GelMA)-encapsulated GOQD-induced hPDLSC sheets on the repair of mandibular periodontal defects in rats. We also explored the molecular biological mechanism through which GOQD promotes bone differentiation. Results There were significant differences in oxygen-containing functional groups, particle size and morphology between Y-GOQDs and B-GOQDs. Y-GOQDs promoted the osteogenic differentiation of hPDLSCs more effectively than did B-GOQDs. In addition, GelMA hydrogel-encapsulated Y-GOQD-induced hPDLSC cell sheet fragments not only exhibited good growth and osteogenic differentiation in vitro but also promoted the repair of mandibular periodontal bone defects in vivo. Furthermore, the greater effectiveness of Y-GOQDs than B-GOQDs in promoting osteogenic differentiation is due to the regulation of hPDLSC mitochondrial dynamics, namely, the promotion of fusion and inhibition of fission. Conclusions Overall, Y-GOQDs are more effective than B-GOQDs at promoting the osteogenic differentiation of hPDLSCs by regulating mitochondrial dynamics, which ultimately contributes to bone regeneration via the aid of the GelMA hydrogels in vivo. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

“…The size of GOQDs is approximately 20 nm, which is much smaller than that of GO [ 12 – 14 ]. Approximately zero-dimensional GOQDs exhibit low cytotoxicity [ 15 , 16 ]. GOQDs can quickly penetrate through the cell membrane without disrupting the lipid membrane structure.…”

Section: Introductionmentioning

confidence: 99%

Human periodontal ligament stem cell sheets activated by graphene oxide quantum dots repair periodontal bone defects by promoting mitochondrial dynamics dependent osteogenic differentiation

An,

Yan,

Qiu

et al. 2024

J Nanobiotechnol

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“…GO has shown significant potential in the field of cancer diagnosis and treatment, with applications spanning early detection, precision drug delivery, therapy enhancement, and treatment monitoring ( 23 - 25 ). As part of biosensors, GO is used to detect cancer biomarkers, enabling early diagnosis and disease monitoring ( 26 ).…”

Section: Applications Of Go In Tumor Diagnosis and Treatmentmentioning

confidence: 99%

The application of graphene oxide and ferroptosis in the diagnosis and treatment of colorectal cancer: a narrative review

Zhou,

Zhang,

Zhu

et al. 2024

J Gastrointest Oncol

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Background and Objective Colorectal cancer (CRC), a leading global malignancy, continues to challenge the medical community. Despite advancements in surgical, chemotherapeutic, radiation, targeted, and immunotherapeutic strategies, issues like resistance and side effects persist. This review illuminates the potential of ferroptosis, an emerging non-apoptotic cell death form, and graphene oxide (GO), with its distinctive physicochemical properties, in CRC therapy. Methods The databases search included PubMed, Medline and Web of Science. Search terms focused on CRC, graphene, GO, ferroptosis, and related aspects in therapy and drug delivery. The time frame for literature retrieval was up to April 2024. Studies in languages other than English were excluded. Key Content and Findings Ferroptosis has been recognized for its role in addressing treatment resistance, a notable hurdle in effective CRC management. This form of cell death offers a promising avenue for enhancing the effectiveness of existing treatments. However, understanding its mechanisms and clinical implications in CRC remains an area of active research, with significant progress required for its practical application. Simultaneously, GO, a versatile two-dimensional material, has demonstrated substantial potential in biomedical applications, especially in cancer therapy. Its high specific surface area and unique π-electron domains facilitate the effective binding of chemotherapy drugs, target genes, and photosensitizers. This makes GO a promising candidate in cancer diagnosis and treatment, particularly through tumor photothermal and photodynamic therapy (PDT). Despite these advancements, GO’s clinical application faces challenges, including in vitro cytotoxicity and decreased biodegradability, necessitating further research. Conclusions This review focuses on the characteristics of GO and ferroptosis, as well as their applications in tumor diagnosis and treatment, with a particular emphasis on their potential in CRC.

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Two‐Pronged Attack: Dual Activation of Fat Reduction Using Near‐Infrared‐Responsive Nanosandwich for Targeted Anti‐Obesity Treatment

Xiao,

Tang,

Chen

et al. 2024

Advanced Science

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Excessive fat accumulation and chronic inflammation are two typical characteristics of obesity. AMP‐activated protein kinase (AMPK), a master regulator of energy metabolism, is involved in adipogenesis, lipogenesis, and inflammation modulation in adipose tissue (AT). Thus, effective lipid reduction and anti‐inflammation through AMPK regulation play vital roles in treating obesity. Herein, an anti‐obesity nanosandwich is fabricated through attaching polymetformin (PolyMet) onto photothermal agent black phosphorus nanosheets (BP). PolyMet activates AMPK to inhibit adipogenesis, promote browning, and mitigate AT inflammation by decreasing macrophage infiltration, repolarizing macrophage phenotype, and downregulating pro‐inflammatory cytokines. Additionally, BP induces lipolysis and apoptosis of adipocytes and macrophages through a photothermal effect. By further functionalization using hyaluronic acid (HA) and MMP2 substrate‐linking P3 peptide‐modified HA (P3‐HA), an enhanced anti‐obesity effect is obtained by dual‐targeting of P3 and HA, and HA‐mediated CD44 poly‐clustering after MMP2 cleavage. Upon laser irradiation, the designed nanosandwich (P3‐HA/PM@BP) effectively inhibits obesity development in obese mice, increases M2/M1 ratio in AT, reduces the serum levels of cholesterol/triglyceride and improves insulin sensitivity, exhibiting promising research potential to facilitate the clinical development of modern anti‐obesity therapies.

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Hyaluronic acid-graphene oxide quantum dots nanoconjugate as dual purpose drug delivery and therapeutic agent in meta-inflammation

Cited by 14 publications

References 92 publications

Human periodontal ligament stem cell sheets activated by graphene oxide quantum dots repair periodontal bone defects by promoting mitochondrial dynamics dependent osteogenic differentiation

Human periodontal ligament stem cell sheets activated by graphene oxide quantum dots repair periodontal bone defects by promoting mitochondrial dynamics dependent osteogenic differentiation

The application of graphene oxide and ferroptosis in the diagnosis and treatment of colorectal cancer: a narrative review

Two‐Pronged Attack: Dual Activation of Fat Reduction Using Near‐Infrared‐Responsive Nanosandwich for Targeted Anti‐Obesity Treatment

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