Hyaluronic Acid-Functionalized Hollow Mesoporous Silica Nanoparticles as pH-Sensitive Nanocarriers for Cancer Chemo-Photodynamic Therapy

Abstract

Hollow mesoporous silica nanoparticles (HMSNs) served as nanocarriers for transporting doxorubicin hydrochloride (DOX) and indocyanine green (ICG) and were incorporated into a pH-sensitive targeted drug delivery system (DDS). Boronate ester bonds were employed to link HMSNs and dopaminemodified hyaluronic acid (DA-HA), which acted as both the "gatekeeper" and targeting agents (HMSNs-B-HA). Well-dispersed HMSNs-B-HA with a diameter of about 170 nm was successfully constructed. The conclusion was drawn from the in vitro drug release experiment that ICG and DOX (ID) co-loaded nanoparticles

Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

“…The system delivered the encapsulated drug ‘Doxorubicin hydrochloride’ together with the fluorescent dye ‘indocyanine green’ to the cancerous region. The developed system releases the enveloped agents at the targeted site by acting as a pH-sensitive system ( Zhou et al, 2021 ). Chen et al fabricated hybrid MSNs by capping with hyaluronic acid through hydrazine bonds.…”

Multifunctional Nanoplatforms as a Novel Effective Approach in Photodynamic Therapy and Chemotherapy, to Overcome Multidrug Resistance in Cancer

“…Multiple approaches in relation to the development of PDT and chemotherapy combination strategies using MSNs have recently been analyzed. To minimize the side effects and enhance PS delivery, pH-sensitive [ 51 , 52 ] or hyaluronic acid (HAC)-functionalized MSNs have been prepared [ 54 ].…”

“…In 2015, Yang et al [ 41 ] were the first to introduce multifunctional chemo-PDT and fluorescent imaging systems based on mesoporous silica NPs. Subsequently, many types of NPs and PSs were analyzed for the purpose of improving the therapeutic efficacy of PDT and chemotherapy, not only against the multidrug resistant cancer cells [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ], but also against the cancer stem cell phenotype [ 58 , 59 , 60 , 61 ].…”

Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors

“…According to the nanostructure, nanoparticles can be generally categorized into three types: 1) NPs with mixed hydrophilic and hydrophobic domains, 2) NPs with a core-shell structure, and 3) NPs with a double-layered capsule structure ( Figure 2 ). In this respect, natural polysaccharides such as hyaluronic acid (HA) [ 102 , 103 , 104 , 105 ], chitosan [ 102 , 106 , 107 , 108 ], chitin, heparin [ 95 , 99 , 100 ], and fucoidan [ 84 ] have been utilized as potential photosensitizer carriers due to their biocompatibility and biodegradability. In addition, not only polymers but also hydrophobic small molecule anticancer drugs (such as doxorubicin [ 96 ], docetaxel [ 97 , 107 , 109 , 110 ], paclitaxel [ 85 , 93 , 103 , 111 , 112 ], camptothecin, and quercetin [ 113 , 114 ]) can be grafted onto PS.…”