Hyaluronic Acid Fat Graft Myringoplasty Versus Autologous Platelet Rich Plasma

Alhabib, Salman F.; Saliba, Issam

doi:10.14740/jocmr2800w

Cited by 14 publications

(4 citation statements)

References 19 publications

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“…In a study that used PRP in FGM by Fouad et al, 24 the success rate was slightly lower (85.7%) than that in our study (100%). Alhabib and Saliba 26 found the results for PRP myringoplasty were significantly worse than those for HAFGM, and because of the negative results with PRP, the study was not completed. We did not use PRP alone but used PRPG in addition to FGM.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Autologous Platelet-Rich Plasma Gel Fat Graft Myringoplasty and the Fat Graft Myringoplasty for the Closure of Different Sizes of Tympanic Membrane Perforations

Ersözlü

Gültekin

2020

Ear Nose Throat J

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Objective: We aimed to evaluate the effect of autologous platelet-rich plasma gel (PRPG) on fat graft myringoplasty (FGM) in tympanic membrane perforations caused by chronic otitis media. Methods: This retrospective study involved 63 patients who underwent operations between 2015 and 2018. Fat graft myringoplasty was performed with the transcanal approach with and without the use of PRPG in the surgical field. The patients were classified into 2 groups: group A, which included 32 patients who underwent FGM with the use of autologous PRPG, and group B, which included 31 patients who underwent FGM alone. Tympanic membrane perforations were divided into 2 groups: small perforations (1-2 mm) in a single quadrant and large perforations (2-4 mm) in at least 2 quadrants. Results: Both groups were statistically matched regarding age and sex. The mean postoperative follow-up was 11.6 and 12.1 months for groups A and B, respectively. Four months postoperatively, the success rate of the graft in group A (100%) was significantly higher than that in group B (83.8%; P = .03). The preoperative and postoperative median air–bone gaps of the groups were similar ( P = .653 and P = .198, respectively). No worsening of the air–bone gap was noted postoperatively in either group. Conclusions: This study demonstrated that autologous PRPG application during FGM allows for a higher success rate than FGM alone. Furthermore, the use of PRPG with FGM for large perforations increases the success rate. Further studies are needed to investigate the PRPG healing effect on other tympanic membrane perforation closure techniques.

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Section: Discussionmentioning

confidence: 99%

A Comparison of the Autologous Platelet-Rich Plasma Gel Fat Graft Myringoplasty and the Fat Graft Myringoplasty for the Closure of Different Sizes of Tympanic Membrane Perforations

Ersözlü

Gültekin

2020

Ear Nose Throat J

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“…29 In otolaryngology, the wound healing properties of PRP have previously been used to treat tympanic membrane perforation. 35 This prospective clinical report on the use of PRP in the human larynx is unique and builds on recent interest in commissioning bioactive components, including fibroblast growth factors and autologous bone marrow-derived mesenchymal stromal cells, to treat pathologies of the head and neck. Recently Woo et al reported short-term voice improvements following inoffice PRP injections with 11 patients receiving three injections.…”

Section: Discussionmentioning

confidence: 99%

“…In vivo studies revealed the effect of PRP in vocal fold healing in rabbit models following acute vocal fold injury 29 . In otolaryngology, the wound healing properties of PRP have previously been used to treat tympanic membrane perforation 35 . This prospective clinical report on the use of PRP in the human larynx is unique and builds on recent interest in commissioning bioactive components, including fibroblast growth factors and autologous bone marrow‐derived mesenchymal stromal cells, to treat pathologies of the head and neck.…”

Section: Discussionmentioning

confidence: 99%

Safety of Platelet‐Rich Plasma Subepithelial Infusion for Vocal Fold Scar, Sulcus, and Atrophy

et al. 2022

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Objective To demonstrate the safety profile of platelet‐rich plasma (PRP) as an injectable therapeutic for the treatment of vocal fold scarring and atrophy. Methods Preliminary report on a prospective clinical trial of patients with vocal fold scar or atrophy undergoing unilateral vocal fold subepithelial infusion with autologous PRP. Enrolled patients underwent four subepithelial injections spaced 1 month apart. Adverse events were assessed peri and post‐injection at each session. Patient‐reported outcomes were collected at every visit using the Voice Handicap Index‐10 (VHI‐10) and Vocal Fatigue Index (VFI) questionnaires. Results Twelve patients underwent unilateral vocal fold injection with autologous PRP prepared according to Eclipse PRP® system protocol. Forty‐three injections were performed using a peroral or percutaneous approach. An average of 1.57 ± 0.4 cc (range 0.6–2.0 cc) injectate was used. All patients tolerated the procedure without difficulty or peri‐procedural complications. The average duration of follow‐up was 3.6 ± 1.8 months. No significant inflammatory reactions or adverse events were seen to date. There was statistically significant improvement in patient‐reported outcomes at the 3 month follow up (n = 9) follow‐up (mean ΔVHI‐10 = 10.8, p < 0.001, mean ΔVFI = 18.9, p = 0.01, t test, paired two sample for means, two‐tail). All nine patients who completed the series of four injections subjectively (yes/no) reported they were satisfied with the results. Conclusion This prospective study cohort demonstrated a favorable safety profile, with no adverse events or peri‐procedural complications. Subjective improvements in vocal quality and reduction in vocal fatigue need to be clinically correlated with further study. Level of Evidence 4 Laryngoscope, 133:647–653, 2023

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“…Saeedi et al [ 14 ] combined Gelfoam with PRP to repair perforations, and the closure rates in the PRP group (66.7%) and the control group (25%) were both lower than those in other studies using autografts. Alhabib et al [ 44 ] also inserted PRP directly through the perforation toward the middle ear rather than in combination with autografts to repair perforations. This study was aborted due to a low success rate of 18.2% [2/11].…”

Section: Discussionmentioning

confidence: 99%

Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis

Huang

Shi

et al. 2021

PLoS ONE

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Background Tympanic membrane (TM) perforation is quite common in the clinical setting. Chronic TM perforations require surgical treatments such as myringoplasty. Currently, platelet-rich plasma (PRP) is a novel, effective substance that is increasingly utilized for TM perforation repair. This study aims to evaluate the effectiveness of PRP in the application of TM perforation repair. Methods A systematic search was conducted to screen the Medline, Embase, Cochrane, Scopus and Web of Science databases up to July 2020. Studies were identified in accordance with the selection criteria by two coauthors independently. Data regarding the healing and hearing outcomes were pooled and analyzed via Review Manager version 5.3 and STATA version 12.0 software. Odds ratio (OR) was utilized to compare the closure rate. Furthermore, the results of hearing improvements and incidence of complications were also compared to evaluate the effectiveness of PRP. Results A total of eight studies with 455 participants were eligible according to the selection criteria. Compared to conventional surgery, the OR of closure was 2.70 (95% CI: 1.27 to 5.76, P = 0.01, I2 = 0%) in randomized controlled trial (RCT) subgroup and 6.18 (95% CI: 2.22 to 17.25, P = 0.0005, I2 = 0) in non-RCT subgroup. The overall OR of closure was 3.69 (95% CI: 2.02 to 6.74, P<0.0001, I2 = 0%), suggesting a significant effect on the healing of TM perforation. Between preoperative and postoperative hearing results, there is no statistical difference between the PRP and the control groups. Additionally, the use of PRP resulted in a lower incidence of complication than the use of conventional approaches. Conclusion The application of PRP during the TM surgeries can enhance the closure rate, provide similar hearing improvements and decrease the incidence of postoperative complications. Given these advantages, PRP can be considered an effective treatment for TM regeneration.

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Hyaluronic Acid Fat Graft Myringoplasty Versus Autologous Platelet Rich Plasma

Cited by 14 publications

References 19 publications

A Comparison of the Autologous Platelet-Rich Plasma Gel Fat Graft Myringoplasty and the Fat Graft Myringoplasty for the Closure of Different Sizes of Tympanic Membrane Perforations

A Comparison of the Autologous Platelet-Rich Plasma Gel Fat Graft Myringoplasty and the Fat Graft Myringoplasty for the Closure of Different Sizes of Tympanic Membrane Perforations

Safety of Platelet‐Rich Plasma Subepithelial Infusion for Vocal Fold Scar, Sulcus, and Atrophy

Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis

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