Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: A systematic review and meta‐analysis of randomized controlled trials

Voigt, Jeffrey; Driver, Vickie R.

doi:10.1111/j.1524-475x.2012.00777.x

Cited by 209 publications

(184 citation statements)

References 44 publications

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“…82,83 By contrast, the mvShh provided a therapeutic effect after a single treatment over the 27-day duration of wound healing. Thus, the treatment effect observed in the mvShh group is due to the multivalent conjugation of Shh to HyA, and based on our in vitro results, we expect that the bioactivity advantage of mvShh complements any improvement in protein stability associated with conjugation to a long-chain biopolymer.…”

Section: Discussionmentioning

confidence: 99%

Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing

Han

Layman

Rode

et al. 2015

Tissue Engineering Part A

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Despite their preclinical promise, few recombinant growth factors have been fully developed into effective therapies, in part, due to the short interval of therapeutic activity after administration. To address this problem, we developed nanoscale polymer conjugates for multivalent presentation of therapeutic proteins that enhance the activation of targeted cellular responses. As an example of this technology, we conjugated multiple Sonic hedgehog (Shh) proteins onto individual hyaluronic acid biopolymers to generate multivalent protein clusters at defined ratios (i.e., valencies) that yield enhanced Shh pathway activation at equivalent concentrations relative to unconjugated Shh. In this study, we investigated whether these multivalent conjugates (mvShh) could be used to improve the therapeutic function of Shh. We found that a single treatment with mvShh significantly accelerated the closure of full-thickness wounds in diabetic (db/db) mice compared to either an equivalent dose of unconjugated Shh or the vehicle control. Furthermore, we identified specific indicators of wound healing in fibroblasts and endothelial cells (i.e., transcriptional activation and cell migration) that were activated by mvShh in vitro and at concentrations approximately an order of magnitude lower than the unconjugated Shh. Taken together, our findings suggest that mvShh conjugates exhibit greater potency to activate the Shh pathway, and this multivalency advantage improves its therapeutic effect to accelerate wound closure in a diabetic animal model. Our strategy of multivalent protein presentation using nanoscale polymer conjugates has the potential to make a significant impact on the development of protein-based therapies by improving their in vivo performance.

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Section: Discussionmentioning

confidence: 99%

Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing

Han

Layman

Rode

et al. 2015

Tissue Engineering Part A

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“…It was found that the product promotes healing when compared to other treatments (26) . In a randomized controlled trial, the efficacy of hyaluronic acid in the treatment of venous ulcers was compared to a neutral carrier.…”

Section: Discussionmentioning

confidence: 98%

Hyaluronic acid covers in burn treatment: a systematic review

Dalmedico

Meier

Félix

et al. 2016

Rev. esc. enferm. USP

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OBJECTIVE To evaluate the effectiveness of hyaluronic acid in the healing of partial thickness burns. METHOD Systematic review of randomized controlled trials on the use of hyaluronic acid for the topical treatment of skin burns, based on recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. RESULTS Two randomized controlled trials that analyzed 143 patients with partial thickness burns and/or deep partial thickness burns were selected. They compared the application of hyaluronic acid 0.2% associated to silver sulfadiazine 1% 5g/cm2 versus silver sulfadiazine 1% 5g/cm2 alone for the outcome of complete healing. CONCLUSION This review emphasizes the need for new well-designed randomized controlled trials to establish the therapeutic relevance of hyaluronic acid with respect to the healing of burns of partial thickness or deep partial thickness.

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“…93 Intraperitoneal injection of hyaluronan suppresses immune activation in a murine model of colitis 94 and may also promote the proliferation of antiinflammatory IL-10-secreting T-regulatory cells. 95 Numerous clinical studies have demonstrated the effectiveness of glycosaminoglycan preparations in enhancing wound healing, 96 and glycosaminoglycans may function similarly to enhance GI wound healing. 97 Characterization of human milk glycosaminoglycans and proteoglycans may guide the development of specific glycosaminoglycan-and proteoglycan-based immunomodulators.…”

Section: Anti-inflammatory Glycosaminoglycansmentioning

confidence: 99%

Clinical applications of bioactive milk components

Hill

Newburg

2015

Nutrition Reviews

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Milk represents a unique resource for translational medicine: It contains a rich pool of biologically active molecules with demonstrated clinical benefits. The ongoing characterization of the mechanistic process through which milk components promote development and immunity has revealed numerous milk-derived compounds with potential applications as clinical therapies in infectious and inflammatory disease, cancer, and other conditions. Lactoferrin is an effective antimicrobial and antiviral agent in high-risk patient populations and a potentially potent adjuvant to chemotherapy in lung cancer. Enteric nutrition formulas supplemented with transforming growth factor b, a milk cytokine, have been shown to promote remission in pediatric Crohn's disease. A number of milk glycans, including human milk oligosaccharides, show promise in preclinical studies as antimicrobial and antiinflammatory agents. While active preclinical investigations of human milk may soon result in large-scale production of human milk molecules, bovine milk components in many instances represent a practical source of bioactive milk compounds for use in clinical trials. This review summarizes current efforts to translate the compounds derived from human and bovine milk into effective clinical therapies. These efforts suggest a common pathway for the translation of milk-derived compounds into clinical applications.

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Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: A systematic review and meta‐analysis of randomized controlled trials

Cited by 209 publications

References 44 publications

Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing

Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing

Hyaluronic acid covers in burn treatment: a systematic review

Clinical applications of bioactive milk components

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