Hyaluronic acid-cross-linked filler stimulates collagen type 1 and elastic fiber synthesis in skin through the TGF-β/Smad signaling pathway in a nude mouse model

A multi‐center, open‐label, pilot study of allograft adipose matrix for the correction of atrophic temples

“…A recent study of the use of injectable hyaluronic acid gel to correct volume loss of facial temporal fossa showed that the effects of the gel persisted at least 12 months in 98% of subjects . Although cross‐linked hyaluronic acid also stimulates the production of dermal collagen and elastin, there is no evidence that this synthetic filler retains critical structural proteins as well as key angiogenic and adipogenic factors that support fat formation when injected in the host. These unique properties of AAM suggest that the AAM creates a functional, three‐dimensional scaffold into which adipocytes may differentiate and thrive .…”

“…Challenges to AFG include inconsistent graft retention, donor site morbidities, insufficient harvest, and excessive harvesting times. Synthetic fillers, such as cross‐linked hyaluronic acid, offer only temporary benefit, although recent evidence suggests that cross‐linked hyaluronic acid stimulates the production of dermal collagen and elastin . Regarding AFG, certain applications (scars and facial contouring) may be revised with small‐volume treatments while others (breasts and buttocks) may be augmented with much larger volumes .…”

Youthful and age-related matreotypes predict drugs promoting longevity

“…There is tantalizing evidence with established longevitypromoting medications, such as rapamycin, resveratrol, metformin, and others ( Figure 1B), and we provided experimental evidence for this with tretinoin, genistein, glucosamine, chondroitin, and hyaluronic acid ( Figure 5). Consistent with this is that glucosamine and chondroitin stimulate collagen synthesis in vitro and ex vivo of elderly human skin in a clinical trial (Gueniche and Castiel-Higounenc, 2017;Lippiello, 2007), extracellular matrix component hyaluronic acid treatments stimulate collagen synthesis in human photo-aged skin (Wang et al, 2007), and in mice (Fan et al, 2019), and topical application of rapamycin restores collagen VII levels in a clinical trial (NCT03103893) (Chung et al, 2019). ECM homeostasis might remodel or prevent glycation and crosslinking of collagens (Ewald, 2019).…”

Biological Effects of Hyaluronic Acid-Based Dermal Fillers and Laser Therapy on Human Skin Models

“…Moreover, we detected that primarily HA fillers with fine particles promote collagen synthesis, which in previous studies was associated with increased TGF-β signaling. 3 So far, scientific knowledge about the combined use of HA fillers and laser treatment is still limited. 4 Our results revealed synergistic effects of fractional ablative laser treatment and injection of HA dermal fillers supporting a combination of both treatments.…”