Hyaluronic acid counteracts interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes

Karna, Ewa; Miltyk, Wojciech; Pałka, Jerzy; Jarząbek, Katarzyna; Wołczyński, Sławomir

doi:10.1016/j.phrs.2006.06.002

Cited by 45 publications

(30 citation statements)

References 35 publications

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“…HA has been shown to protect against type II collagen degradation in articular chondrocytes. [28][29][30][31] This protective effect could be due to its inhibitory effect on main catabolic enzyme, such as MMP-13. 32 Nevertheless, the reduction of Coll2-1 NO 2 observed with HA could be attributable to its inhibitory potency on nitric oxide pathway 33 and other oxidative stress mechanism.…”

Section: Discussionmentioning

confidence: 99%

Early decrease of serum biomarkers of type II collagen degradation (Coll2‐1) and joint inflammation (Coll2‐1 NO₂) by hyaluronic acid intra‐articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study

Henrotin

Chevalier²,

Deberg³

et al. 2013

Journal Orthopaedic Research

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To measure the evolution of the serum levels of specific Osteoarthritis (OA) biomarker, Coll2-1 and Coll2-1 NO 2 in knee osteoarthritic patients after viscosupplementation (VS). Fifty-one patients with unilateral symptomatic knee were recruited for this prospective open label study. They received three intra-articular injections of 2 ml of hyaluronic acid (Hylan GF-20) and were followed for 3 months. Walking pain was evaluated and serum samples were taken at each visit. Coll2-1 and Coll2-1 NO 2 were measured in the serum using specific immunoassays. Variations over time of each parameter and predictive factor of response were studied. Forty-five patients were analyzed. The serum concentrations of Coll2-1 and Coll2-1 NO 2 were significantly higher in KL III/IV patients compared to KL I/II patients at baseline and decreased systematically over time after VS. Its effect was ever more pronounced in patients with KL III/IV. The serum concentration of Coll2-1 was significantly lower at baseline in responders than in non-responders. This study suggests a rapid slowdown of type II collagen degradation and joint inflammation after VS with Hylan G-20 and gives additional information for the validation of accurate biomarkers for OA. The serum level of Coll2-1 appeared to be a predictive factor for response to treatment. ß

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Section: Discussionmentioning

confidence: 99%

Early decrease of serum biomarkers of type II collagen degradation (Coll2‐1) and joint inflammation (Coll2‐1 NO₂) by hyaluronic acid intra‐articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study

Henrotin

Chevalier²,

Deberg³

et al. 2013

Journal Orthopaedic Research

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“…HA is present at high concentrations in the tunica albuginea and controls the distribution of nutrients in the connective tissue as a result of its hydrating action. Furthermore, HA counteracts the effect of inflammatory cytokines [22,23].…”

Section: Introductionmentioning

confidence: 99%

Intralesional hyaluronic acid: an innovative treatment for Peyronie’s disease

Romano¹,

Barletta

Paulis

2015

Int Urol Nephrol

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“…IL-1β could stimulate the expression of MMPs (18,19) and inhibit collagen biosynthesis (17,20). We also examined the mRNA expression of IL-1β, and the results showed that IL-1β was up-regulated at the lumbar discs of the model group, but down-regulated by the treatment of FFQSP at the 7th and 9th month.…”

Section: Discussionmentioning

confidence: 99%

Herb Formula “Fufangqishe-Pill” Prevents Upright Posture–Induced Intervertebral Disc Degeneration at the Lumbar in Rats

Qian

Bian

et al. 2010

J Pharmacol Sci

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Abstract. Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.

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Hyaluronic acid counteracts interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes

Cited by 45 publications

References 35 publications

Early decrease of serum biomarkers of type II collagen degradation (Coll2‐1) and joint inflammation (Coll2‐1 NO₂) by hyaluronic acid intra‐articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study

Early decrease of serum biomarkers of type II collagen degradation (Coll2‐1) and joint inflammation (Coll2‐1 NO₂) by hyaluronic acid intra‐articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study

Intralesional hyaluronic acid: an innovative treatment for Peyronie’s disease

Herb Formula “Fufangqishe-Pill” Prevents Upright Posture–Induced Intervertebral Disc Degeneration at the Lumbar in Rats

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Hyaluronic acid counteracts interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes

Cited by 45 publications

References 35 publications

Early decrease of serum biomarkers of type II collagen degradation (Coll2‐1) and joint inflammation (Coll2‐1 NO2) by hyaluronic acid intra‐articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study

Early decrease of serum biomarkers of type II collagen degradation (Coll2‐1) and joint inflammation (Coll2‐1 NO2) by hyaluronic acid intra‐articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study

Intralesional hyaluronic acid: an innovative treatment for Peyronie’s disease

Herb Formula “Fufangqishe-Pill” Prevents Upright Posture–Induced Intervertebral Disc Degeneration at the Lumbar in Rats

Contact Info

Product

Resources

About

Early decrease of serum biomarkers of type II collagen degradation (Coll2‐1) and joint inflammation (Coll2‐1 NO₂) by hyaluronic acid intra‐articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study

Early decrease of serum biomarkers of type II collagen degradation (Coll2‐1) and joint inflammation (Coll2‐1 NO₂) by hyaluronic acid intra‐articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study