Hyaluronic Acid-Conjugated Mesoporous Silica Nanoparticles Loaded with Dual Anticancer Agents for Chemophotodynamic Cancer Therapy

Park, Sang-hyo; Park, Hyungkyu; Jeong, Seokhyeon; Yi, Bong Gu; Park, Kyeongsoon; Key, Jaehong

doi:10.1155/2019/3481397

Cited by 19 publications

(6 citation statements)

References 51 publications

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“…The bright‐field image analysis further revealed that significant accumulation of AuraTherm inside the cell after 6 h and 24 h. At the same time, free HA pretreatment showed a decrease in the number of AuraTherm inside the cells with a maximum number outside of the cells. This suggests that HA pretreatment blocks the CD44 receptors on the cell's surface and, thus, competes with the receptor‐mediated endocytosis of AuraTherm (32).…”

Section: Resultsmentioning

confidence: 99%

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Kalyane

Polaka

Vasdev

et al. 2022

Photochem & Photobiology

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This investigation reports the quality‐by‐design (QbD) assisted novel templated approach for developing cancer cell‐specific and laser‐activatable nanoseeds (AuraTherm) for targeted photothermal ablation of triple‐negative breast cancer (TNBC). AuraTherm was nanometric in size as characterized by SEM, TEM and particle analysis (80.28 ± 2.56 nm; −21.80 ± 0.17 mV) with hemocompatibility and neutrality towards blood components. AuraTherm showed reversible photothermal effect (ΔT: 37 ± 1.2°C → 49.4 ± 1.5°C; 15 min; 2.4 W cm−2) employing near‐infrared 808 nm laser (NIR‐808). The targeted cytosolic localization led to a significant anticancer activity as evaluated using apoptosis assay, cell cycle analysis, Intracellular ROS generation assay, cellular uptake and receptor binding assay. The NIR‐808 laser‐responsive photothermal ablation of cancer cell was found to be more effective compared to without NIR‐808 laser‐treated counterparts, suggesting the fundamental role of photothermal ablation in the treatment of TNBC.

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Section: Resultsmentioning

confidence: 99%

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Kalyane

Polaka

Vasdev

et al. 2022

Photochem & Photobiology

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“…242,243 HA-functionalized MSNPs incorporating doxorubicin (DOX) and a photosensitizer Chlorin e6 (Ce6) was used in photodynamic therapy (PDT) and chemotherapy to treat squamous cell carcinoma 7 (SCC7). 244 The nanoconjugate (DOX/Ce6/HA-MSNP) binds CD44 ligand, and the whole complex undergoes endocytosis to exhibit photoinduced toxicity by forming highly reactive singlet oxygen (SO) in SCC7 cells. In other related studies, (i) doxorubicin loaded on HA-MSNPs functionalized with polyethyleneimine (PEI) has been used for targeted delivery with increased endosomal escape efficiency and controlled drug release; 245 (ii) CD44-targeted HA nanoparticles were used to deliver siRNA into tumor cells; 246 and (iii) HA-PEI/HA-PEG-based nanoparticles were also used to target CD44 on ovarian cancer for delivery of MDR1 siRNA in vivo to enhance drug potency and overcome MDRI-related multidrug resistance.…”

Section: Glycosaminoglycan−polymer Conjugatesmentioning

confidence: 99%

“…HA-functionalized MSNPs incorporating doxorubicin (DOX) and a photosensitizer Chlorin e6 (Ce6) was used in photodynamic therapy (PDT) and chemotherapy to treat squamous cell carcinoma 7 (SCC7) . The nanoconjugate (DOX/Ce6/HA-MSNP) binds CD44 ligand, and the whole complex undergoes endocytosis to exhibit photoinduced toxicity by forming highly reactive singlet oxygen (SO) in SCC7 cells.…”

Section: Synthetic Glycoconjugatesmentioning

confidence: 99%

Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments

Shivatare

Wong

2022

Chem. Rev.

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Glycoconjugates are major constituents of mammalian cells that are formed via covalent conjugation of carbohydrates to other biomolecules like proteins and lipids and often expressed on the cell surfaces. Among the three major classes of glycoconjugates, proteoglycans and glycoproteins contain glycans linked to the protein backbone via amino acid residues such as Asn for N-linked glycans and Ser/Thr for O-linked glycans. In glycolipids, glycans are linked to a lipid component such as glycerol, polyisoprenyl pyrophosphate, fatty acid ester, or sphingolipid. Recently, glycoconjugates have become better structurally defined and biosynthetically understood, especially those associated with human diseases, and are accessible to new drug, diagnostic, and therapeutic developments. This review describes the status and new advances in the biological study and therapeutic applications of natural and synthetic glycoconjugates, including proteoglycans, glycoproteins, and glycolipids. The scope, limitations, and novel methodologies in the synthesis and clinical development of glycoconjugates including vaccines, glyco-remodeled antibodies, glycan-based adjuvants, glycan-specific receptor-mediated drug delivery platforms, etc., and their future prospectus are discussed.

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“…The HA-MSNs are absorbed at almost a three times higher rate than the free MSNs in squamous cell carcinoma 7 (SCC7) cells. To improve the anticancer effects of chemotherapy and photodynamic therapy (PDT), DOX and chlorine e6 (Ce6) are loaded in the HA-MSNs (DOX/Ce6/HA-MSNs) where the formulation demonstrates a higher cytotoxicity on the SCC7 than the free DOX, HA-MSNs-DOX, or Ce6 alone, suggesting significant therapeutic effects of chemo-PDT [ 142 ]. The HA-MSNs synthesized via a facile amidation reaction has been proposed as an efficient strategy to overcome the MSNs agglomeration problem in physiological fluids.…”

Section: Drug Loading Release and Cellular Uptakementioning

confidence: 99%

Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles

et al. 2022

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Mesoporous silica nanoparticles (MSNs) have great potential for applications as a drug delivery system (DDS) due to their unique properties such as large pore size, high surface area, biocompatibility, biodegradability, and stable aqueous dispersion. The MSN-mediated DDS can carry chemotherapeutic agents, optical sensors, photothermal agents, short interfering RNA (siRNA), and gene therapeutic agents. The MSN-assisted imaging techniques are applicable in cancer diagnosis. However, their synthesis via a chemical route requires toxic chemicals and is challenging, time-consuming, and energy-intensive, making the process expensive and non-viable. Fortunately, nature has provided a viable alternative material in the form of biosilica from marine resources. In this review, the applications of biosilica nanoparticles synthesized from marine diatoms in the field of drug delivery, biosensing, imaging agents, and regenerative medicine, are highlighted. Insights into the use of biosilica in the field of DDSs are elaborated, with a focus on different strategies to improve the physico-chemical properties with regards to drug loading and release efficiency, targeted delivery, and site-specific binding capacity by surface functionalization. The limitations, as well as the future scope to develop them as potential drug delivery vehicles and imaging agents, in the overall therapeutic management, are discussed.

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Hyaluronic Acid-Conjugated Mesoporous Silica Nanoparticles Loaded with Dual Anticancer Agents for Chemophotodynamic Cancer Therapy

Cited by 19 publications

References 51 publications

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments

Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles

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