Hyaluronic acid coating on the surface of curcumin-loaded ZIF-8 nanoparticles for improved breast cancer therapy: An in vitro and in vivo study

Yu, Shaoxuan; Wang, Shanyu; Xie, Zhike; Li, Ling; Xiao, Haifang; Song, Yuanda

doi:10.1016/j.colsurfb.2021.111759

Cited by 61 publications

(44 citation statements)

References 51 publications

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“…Compared with the Cur group, Cur@HFn induced a greater proportion of 4T1 cell apoptosis ( p < .001), reaching 15% of cell apoptosis. The enhanced cancer cell suppression effect of Cur@HFn may be attributed to the high-efficiency targeted cell uptake and cur enrichment to produce excessive ROS (Yu et al., 2021 ), which is consistent with the above-mentioned in vitro cytotoxicity test results. Nuclei were visualized by counterstaining with DAPI (blue, Figure S3C ).…”

Section: Resultssupporting

confidence: 76%

“…The findings indicate that the loading of Cur will not affect the structural conformation and monodispersed state of HFn, and the Cur@HFn delivery system has good physical stability and uniform distribution. In addition, the slight negative charge on the surface of Cur@HFn and the appropriate particle size can also help shield the reticuloendothelial system, prolong blood circulation and enhance cell uptake in the body (Yu et al., 2021 ). According to Figure 1(E) , with absorbance ( y ) as the ordinate and concentration ( x ) as the abscissa, the standard curve equation of Cur is obtained: y = 0.18519 x + 0.00786 ( R 2 =0.99968).…”

Section: Resultsmentioning

confidence: 99%

“…4T1 tumor-bearing mice were used to evaluate the anti-tumor efficacy of Cur@HFn in vivo (Kim et al., 2021 ; Yu et al., 2021 ). Female mice were inoculated with a suspension of 4T1 cells in physiological saline (100 μL, 1 × 10 6 cells) into the right mammary gland.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity

Wang

Yin

et al. 2022

Drug Delivery

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Breast cancer is prevalent and diverse with significantly high incidence and mortality rates. Curcumin (Cur), a polyphenol component of turmeric, has been widely recognized as having strong anti-breast cancer activity. However, its anti-cancer efficiency is largely impaired by some of its concomitant negative properties, including its poor solubility, low cellular uptake, and severe reported side effects. Hence, the necessity arises to develop a novel low-toxic and high-efficiency targeting drug delivery system (DDS). In this study, we developed a pH-sensitive tumor self-targeting DDS (Cur@HFn) based on self-assembled HFn loaded with Cur, in which Cur was encapsulated into HFn cavity by using a disassembly/reassembly strategy, and the Cur@HFn was characterized by ultraviolet–visible (UV–vis), dynamic light scattering (DLS), and transmission electron microscope (TEM). A variety of breast cancer cell models were built to evaluate cytotoxicity, apoptosis, targeting properties, and uptake mechanism of the Cur@HFn. The pharmacodynamics was also evaluated in tumor (4T1) bearing mice after intravenous injection. In vitro release experiments showed that Cur@HFn is pH sensitive and shows sustained drug release under slightly acidic conditions. Compared with Cur, Cur@HFn has stronger cytotoxicity, cellular uptake, and targeting performance. Our study supported that Cur@HFn has a higher in vivo therapeutic effect and lower systemic toxicity. The safety evaluation results indicated that Cur@HFn has no hematotoxicity, hepatotoxicity, and nephrotoxicity. The findings of the present study showed that the Cur@HFn has been successfully prepared and has potential application value in the treatment of breast cancer.

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Section: Resultssupporting

confidence: 76%

Section: Resultsmentioning

confidence: 99%

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Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity

Wang

Yin

et al. 2022

Drug Delivery

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“…In vivo , tumor growth and lung metastasis could be effectively inhibited by 4T1 cell targeting of Cur@ZIF8@HA and the release of Cur in response to acidic pH. Cur@ZIF-8@HA showed excellent potential in breast cancer therapy and combining HA and MOF to prepare nanoparticles provides a new direction for developing anti-breast cancer drug delivery systems ( Yu et al, 2021 ).…”

Section: Ha Hybrid Nddssmentioning

confidence: 99%

Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances

Jia

Chen

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Breast cancer (BC) is the most common malignancy among females worldwide, and high resistance to drugs and metastasis rates are the leading causes of death in BC patients. Releasing anti-cancer drugs precisely to the tumor site can improve the efficacy and reduce the side effects on the body. Natural polymers are attracting extensive interest as drug carriers in treating breast cancer. Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility, biodegradability, and non-immunogenicity and is a significant component of the extracellular matrix. The CD44 receptor of HA is overexpressed in breast cancer cells and can be targeted to breast tumors. Therefore, many researchers have developed nano drug delivery systems (NDDS) based on the CD44 receptor tumor-targeting properties of HA. This review examines the application of HA in NDDSs for breast cancer in recent years. Based on the structural composition of NDDSs, they are divided into HA NDDSs, Modified HA NDDSs, and HA hybrid NDDSs.

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“…ZIFs have gained technical and scientific attention due to their pore-structural network, and have many potential applications in the fields of photocatalysis [103], drug delivery [104], pharmaceutical compounds separation [105,106], dye-wasted water treatment [107], oil-water separation [108], water purification [109,110], the pervaporation recovery of solvent vapors [109,[111][112][113], electrocatalysts [114], solvent-resistant nanofiltration [115], gas-liquid separation [116], natural gas separation [117][118][119] and so on. As described in Figure 2, MMMs may provide separation properties that can overcome the Robeson upper bound.…”

Section: Polymer/zif Mixed Matrix Membranesmentioning

confidence: 99%

Recent Advances in Polymer-Inorganic Mixed Matrix Membranes for CO2 Separation

Liu

Wong

et al. 2021

Polymers

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Since the second industrial revolution, the use of fossil fuels has been powering the advance of human society. However, the surge in carbon dioxide (CO2) emissions has raised unsettling concerns about global warming and its consequences. Membrane separation technologies have emerged as one of the major carbon reduction approaches because they are less energy-intensive and more environmentally friendly compared to other separation techniques. Compared to pure polymeric membranes, mixed matrix membranes (MMMs) that encompass both a polymeric matrix and molecular sieving fillers have received tremendous attention, as they have the potential to combine the advantages of both polymers and molecular sieves, while cancelling out each other’s drawbacks. In this review, we will discuss recent advances in the development of MMMs for CO2 separation. We will discuss general mechanisms of CO2 separation in an MMM, and then compare the performances of MMMs that are based on zeolite, MOF, metal oxide nanoparticles and nanocarbons, with an emphasis on the materials’ preparation methods and their chemistries. As the field is advancing fast, we will particularly focus on examples from the last 5 years, in order to provide the most up-to-date overview in this area.

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Hyaluronic acid coating on the surface of curcumin-loaded ZIF-8 nanoparticles for improved breast cancer therapy: An in vitro and in vivo study

Cited by 61 publications

References 51 publications

Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity

Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity

Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances

Recent Advances in Polymer-Inorganic Mixed Matrix Membranes for CO2 Separation

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