Hyaluronic acid-coated chitosan nanoparticles as carrier for the enzyme/prodrug complex based on horseradish peroxidase/indole-3-acetic acid: Characterization and potential therapeutic for bladder cancer cells

Pereira, Fernanda Menezes; Melo, Micael Nunes; Santos, Atali Kayane Mendes; Oliveira, Karony Vieira; Diz, Fernando Mendonça; Ligabue, Rosane Angélica; Morrone, Fernanda Bueno; Severino, Patrícia; Fricks, Alini Tinoco

doi:10.1016/j.enzmictec.2021.109889

Cited by 18 publications

(6 citation statements)

References 110 publications

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“…The absorption band at 1735.45 cm −1 showed the protonation that occurred in the formation of the polyelectrolyte complex [ 63 , 76 ]. Moreover, the amplification of the peak corresponding to the amide I and II bands, with a small shift to wave numbers 1628.39 and 1558.62 cm −1 , showed effective amide bonding between the amino and carboxylic groups on the HA and the surface of the nanoparticles [ 42 , 63 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

“…The DSC thermogram of AM nanoparticles coated with HA exhibited a loss of the peak from CS accompanied by shifting of the HA peak to 94 °C and a loss of the exothermic peak at 236 °C from HA, which is thought to be due to the structural modification of HA after electrostatic interaction with CS [ 77 , 79 ]. Furthermore, AM exhibited a significant endothermal peak around 178 °C due to the melting of AM crystals.…”

Section: Discussionmentioning

confidence: 99%

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Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells

et al. 2023

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Alpha mangostin (AM) has potential anticancer properties for breast cancer. This study aims to assess the potential of chitosan nanoparticles coated with hyaluronic acid for the targeted delivery of AM (AM-CS/HA) against MCF-7 breast cancer cells. AM-CS/HA showed a spherical shape with an average diameter of 304 nm, a polydispersity index of 0.3, and a negative charge of 24.43 mV. High encapsulation efficiency (90%) and drug loading (8.5%) were achieved. AM released from AM-CS/HA at an acidic pH of 5.5 was higher than the physiological pH of 7.4 and showed sustained release. The cytotoxic effect of AM-CS/HA (IC50 4.37 µg/mL) on MCF-7 was significantly higher than AM nanoparticles without HA coating (AM-CS) (IC50 4.48 µg/mL) and AM (IC50 5.27 µg/mL). These findings suggest that AM-CS/HA enhances AM cytotoxicity and has potential applications for breast cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells

et al. 2023

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“…Hybrid nanomaterials from chitosan and HA were reported for delivery of an enzyme/pro-drug complex containing HRP and indole- cells by up to 88%. 191 Although the internalization mechanism of hybrid nanoparticles in bladder tumor cells was not evaluated, due to modification of HA, they can selectively bind to CD44 receptors on the cell surface to internalize via receptor-mediated endocytosis. The interaction between HA and CD44 has been confirmed in previous experiments.…”

Section: Cancer Cell Internalizationmentioning

confidence: 99%

“…Their encapsulation efficiency was up to 90% and they demonstrated high initial release (72%). These nanoparticles reduced the viability of bladder cancer cells by up to 88% 191 . Although the internalization mechanism of hybrid nanoparticles in bladder tumor cells was not evaluated, due to modification of HA, they can selectively bind to CD44 receptors on the cell surface to internalize via receptor‐mediated endocytosis.…”

Section: Cancer Cell Internalizationmentioning

confidence: 99%

(Nano)platforms in bladder cancer therapy: Challenges and opportunities

Ashrafizadeh

Zarrabi

Karimi‐Maleh

et al. 2022

Bioengineering & Transla Med

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Urological cancers are among the most common malignancies around the world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for the treatment of bladder cancer although its prognosis remains unfavorable. It is perceived that treatment of bladder cancer depends on an interdisciplinary approach combining biology and engineering. The nanotechnological approaches have been introduced in the treatment of various cancers, especially bladder cancer. The current review aims to emphasize and highlight possible applications of nanomedicine in eradication of bladder tumor. Nanoparticles can improve efficacy of drugs in bladder cancer therapy through elevating their bioavailability. The potential of genetic tools such as siRNA and miRNA in gene expression regulation can be boosted using nanostructures by facilitating their internalization and accumulation at tumor sites and cells. Nanoparticles can provide photodynamic and photothermal therapy for ROS overgeneration and hyperthermia, respectively, in the suppression of bladder cancer. Furthermore, remodeling of tumor microenvironment and infiltration of immune cells for the purpose of immunotherapy are achieved through cargo‐loaded nanocarriers. Nanocarriers are mainly internalized in bladder tumor cells by endocytosis, and proper design of smart nanoparticles such as pH‐, redox‐, and light‐responsive nanocarriers is of importance for targeted tumor therapy. Bladder cancer biomarkers can be detected using nanoparticles for timely diagnosis of patients. Based on their accumulation at the tumor site, they can be employed for tumor imaging. The clinical translation and challenges are also covered in current review.

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“…Significantly, IAA can be oxidized by horseradish peroxidase (HRP) and then induces the generation of ROS as well as lesions of DNA [ 102 ]. A CS/HA NP capsuled with IAA or HRP was developed and reduced the cell viability of the human bladder cancer cell line (T24) by 88% [ 103 ]. The hyaluronic acid (HA) mounted on the surface enables a specific adherence to bladder cancer cells.…”

Section: Nanotechnology In Treatmentmentioning

confidence: 99%

State-of-the-Art Advances of Nanomedicine for Diagnosis and Treatment of Bladder Cancer

et al. 2022

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Bladder cancer is a common malignant tumor of the urinary system. Cystoscopy, urine cytology, and CT are the routine diagnostic methods. However, there are some problems such as low sensitivity and difficulty in staging, which must be urgently supplemented by novel diagnostic methods. Surgery, intravesical instillation, systemic chemotherapy, and radiotherapy are the main clinical treatments for bladder cancer. It is difficult for conventional treatment to deal with tumor recurrence, progression and drug resistance. In addition, the treatment agents usually have the defects of poor specific distribution ability to target tumor tissues and side effects. The rapid development of nanomedicine has brought hope for the treatment of bladder cancer in reducing side effects, enhancing tumor inhibition effects, and anti-drug resistance. Overall, we review the new progression of nano-platforms in the diagnosis and treatment of bladder cancer.

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Hyaluronic acid-coated chitosan nanoparticles as carrier for the enzyme/prodrug complex based on horseradish peroxidase/indole-3-acetic acid: Characterization and potential therapeutic for bladder cancer cells

Cited by 18 publications

References 110 publications

Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells

Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells

(Nano)platforms in bladder cancer therapy: Challenges and opportunities

State-of-the-Art Advances of Nanomedicine for Diagnosis and Treatment of Bladder Cancer

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