Hyaluronic acid co-functionalized gold nanoparticle complex for the targeted delivery of metformin in the treatment of liver cancer (HepG2 cells)

Kumar, Chiranjeev; Raja, M. D.; Sundar, D. Sathish; Antoniraj, M. Gover; Ruckmani, K.

doi:10.1016/j.carbpol.2015.04.010

Cited by 86 publications

(60 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the surface modification of superparamagnetic iron oxide (SPIO) NPs was performed by conjugating HA, and the in vitro magnetic resonance (MR) imaging of CD44 + HepG2 cells and in vivo MR imaging of mice HepG2 cell-bearing tumor xenografts confirmed the high efficiency and targeting of liver carcinoma. 87 Furthermore, a HA-capping gold NPs (AuNPs) loaded with metformin (MET) were developed through the amide bond formation between carboxyl groups of HA on AuNPs and amine group of MET, 88 in which the HA serves as a targeting agents for liver cancer cells. The cell apoptosis assay indicated that the drug system pronounced higher apoptotic behavior in HepG2 cells than CD44…”

Section: Polysaccharidesmentioning

confidence: 99%

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Li¹,

Zhang²,

Wang³

et al. 2016

IJN

117

View full text Add to dashboard Cite

Section: Polysaccharidesmentioning

confidence: 99%

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Li¹,

Zhang²,

Wang³

et al. 2016

IJN

117

View full text Add to dashboard Cite

“…Among many metal NPs, gold NPs (AuNPs) have been proposed as particularly attractive radiosensitizers due to their unique physicochemical properties. It is well established that synthetic chemistry of colloidal AuNPs allows precise tailoring of particle size and shape for optimal tissue delivery [19] as well as surface functionality for bio-conjugation to drugs and agents that specifically target tumor cell [20]. Gold NPs can easily enter the systemic circulation and infiltrate tumor tissues, and once inside the tumor they enhance the irradiation effect [14].…”

Section: Introductionmentioning

confidence: 99%

Cellular Uptake and Radio-sensitization Effect of Small Gold Nanoparticles in MCF-7 Breast Cancer Cells

Janic¹,

Liu²,

Bobbitt³

et al. 2018

J Nanomed Nanotechnol

View full text Add to dashboard Cite

show abstract

“…AuNPs have become an important biomedical tool for scientists in cancer research because of the several advantages of it like high loading efficiency for the target substance, enhanced ability to cross various physiological barriers, and low systemic side effects [30][31][32]. AuNPs are a novel agent in cancer therapy and show aggregation and size-dependent cytotoxic activity against different cancer cells.…”

Section: Resultsmentioning

confidence: 99%

Effect of Gold Nanocomposite on the Cytotoxicity of Human Cancer Cell Lines

Abaza¹,

Mahmoud²,

Elsheikh³

2018

JPP

View full text Add to dashboard Cite

Gold nanoparticles (AuNPs) have a biological property that have attracted significant attention in this decade, especially in the field of biomedical application with great therapeutic potential. Additionally, the chitosan molecule appears to be a suitable polymeric complex used in this field. The aim of the current study is to explores the cytotoxicity and the IC 50 value of Au-doped chitosan-poly (vinyl alcohol) (Cs/PVA/Au) nanocomposite that was developed by gamma irradiation with promising anticancer activity. The anti-cancer activity of the prepared nanocomposites was demonstrated in human liver cancer cell line HEPG2 and MCF7 breast cancer cell lines. It has significant effects against both cancer cell line. Concluding that, the future nanomedicine will be impacted greatly by the collaboration of biomedical research and developing nanoparticle therapy in the right directions, which will improve the outcome of cancer patients. It is expected that the next decade will reveal real potential for metal nanoparticles to cross the regulatory barrier into clinical use as effective therapeutics.

show abstract

Hyaluronic acid co-functionalized gold nanoparticle complex for the targeted delivery of metformin in the treatment of liver cancer (HepG2 cells)

Cited by 86 publications

References 49 publications

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Cellular Uptake and Radio-sensitization Effect of Small Gold Nanoparticles in MCF-7 Breast Cancer Cells

Effect of Gold Nanocomposite on the Cytotoxicity of Human Cancer Cell Lines

Contact Info

Product

Resources

About