Hyaluronic Acid-Binding Scaffold for Articular Cartilage Repair

Unterman, Shimon; Gibson, Matthew; Lee, Janice H.; Crist, Joshua; Chansakul, Thanissara; Yang, Eric V.; Elisseeff, Jennifer H.

doi:10.1089/ten.tea.2011.0711

Cited by 80 publications

(53 citation statements)

References 29 publications

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“…65 While the complex cell population accessed in microfracture surgery presents a challenge for experimental models, bone marrow-derived mesenchymal progenitor cells are commonly used in vitro to simulate them. [66][67][68][69][70] To isolate BM-PCs, bone marrow stroma is typically scooped from the diaphyseal marrow cavity of long bones, aspirated from the iliac crest, or separated from sponge-like network of trabecular bone. 43,68 These techniques have also been successfully applied to an array of species, including human, canine, feline, porcine, lapine, and bovine.…”

Section: Discussionmentioning

confidence: 99%

Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment

Liebesny

Byun

Hung

et al. 2016

Tissue Engineering Part A

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Tissue engineering approaches using growth factor-functionalized acellular scaffolds to support and guide repair driven by endogenous cells are thought to require a careful balance between cell recruitment and growth factor release kinetics. The objective of this study was to identify a growth factor combination that accelerates progenitor cell migration into self-assembling peptide hydrogels in the context of cartilage defect repair. A novel 3D gel-to-gel migration assay enabled quantification of the chemotactic impact of platelet-derived growth factor-BB (PDGF-BB), heparin-binding insulin-like growth factor-1 (HB-IGF-1), and transforming growth factorb1 (TGF-b1) on progenitor cells derived from subchondral bovine trabecular bone (bone-marrow progenitor cells, BM-PCs) encapsulated in the peptide hydrogel [KLDL] 3 . Only the combination of PDGF-BB and TGF-b1 stimulated significant migration of BM-PCs over a 4-day period, measured by confocal microscopy. Both PDGF-BB and TGF-b1 were slowly released from the gel, as measured using their 125

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Section: Discussionmentioning

confidence: 99%

Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment

Liebesny

Byun

Hung

et al. 2016

Tissue Engineering Part A

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“…Unterman et al showed that HA-interacting PEG hydrogels improved cartilage tissue formation in vitro and in vivo in instances where HA was presented at a later stage of differentiation, subsequently resulting in increased chondrogenic phenotypes [45]. Here, carefully considering properties of the native environment resulted in increased success by incorporating HA components that mimic the desired tissue.…”

Section: Ascs In Synthetic Scaffolds For Cartilaginous Regenerationmentioning

confidence: 99%

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

et al. 2016

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Regenerative medicine possesses the potential to ameliorate damage to tissue that results from a vast range of conditions, including traumatic injury, tumor resection and inherited tissue defects. Adult stem cells, while more limited in their potential than pluripotent stem cells, are still capable of differentiating into numerous lineages and provide feasible allogeneic and autologous treatment options for many conditions. Adipose stem cells are one of the most abundant types of stem cell in the adult human. Here, we review recent advances in the development of synthetic scaffolding systems used in concert with adipose stem cells and assess their potential use for clinical applications.

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“…Increase and accelerate bone formation in criticallysized segmental defects in rats (147) Hialuronic acid (HA) HA-binding scaffold Improved cartilage tissue production in a rat knee osteochondral defect model (148) Elastin-like polypeptides (ELP) with fibronectin cs5 and a proteolytic domain…”

Section: Hydrogels For Nerve Tissue Regenerationmentioning

confidence: 99%

Integrating Mechanical and Biological Control of Cell Proliferation Through Bioinspired Multieffector Materials

Seras‐Franzoso

Tatkiewicz

Vázquez

et al. 2015

Nanomedicine (Lond.)

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In nature, cells respond to complex mechanical and biological stimuli whose understanding is required for tissue construction in regenerative medicine. However, the full replication of such bimodal effector networks is far to be reached. Engineering substrate roughness and architecture allows regulating cell adhesion, positioning, proliferation, differentiation and survival, and the external supply of soluble protein factors (mainly growth factors and hormones) has been long applied to promote growth and differentiation. Further, bio-inspired scaffolds are progressively engineered as reservoirs for the in situ sustained release of soluble protein factors from functional topographies. We review here how research progresses towards the design of integrative, holistic scaffold platforms based on the exploration of individual mechanical and biological effectors and their further combination.

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Hyaluronic Acid-Binding Scaffold for Articular Cartilage Repair

Cited by 80 publications

References 29 publications

Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment

Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

Integrating Mechanical and Biological Control of Cell Proliferation Through Bioinspired Multieffector Materials

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