Hyaluronic Acid as an Emerging Technology Platform for Silencing RNA Delivery

Kuche, Kaushik; Pandey, Pramina Kumari; Patharkar, Abhimanyu; Maheshwari, Rahul; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814427-5.00012-3

Cited by 3 publications

(1 citation statement)

References 162 publications

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“…Nonetheless, after some time, research started being oriented towards developing natural and synthetic polymer-based nanosystems for TNAs delivery as an alternative for cancer treatments and non-viral vaccine formulations. Polymers such as hyaluronic acid [94,[112][113][114], chitosan [94,113], DEAE dextran [111], poly-L-lysine (PLL) [94], polybeta-amino-esters (PBAE) [111], polyethylenimine (PEI) [94,111], dimethylaminoethyl methacrylate (DEAMA) [111], poly(ethylene glycol) methacrylate (PEGMA) [111], and DEAEMA-co-n-butyl methacrylate [111] represent promising candidates for various TNAs delivery platforms.…”

Section: Polymer-based Delivery Systemsmentioning

confidence: 99%

New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery

2021

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Nucleic acids represent a promising lead for engineering the immune system. However, naked DNA, mRNA, siRNA, and other nucleic acids are prone to enzymatic degradation and face challenges crossing the cell membrane. Therefore, increasing research has been recently focused on developing novel delivery systems that are able to overcome these drawbacks. Particular attention has been drawn to designing lipid and polymer-based nanoparticles that protect nucleic acids and ensure their targeted delivery, controlled release, and enhanced cellular uptake. In this respect, this review aims to present the recent advances in the field, highlighting the possibility of using these nanosystems for therapeutic and prophylactic purposes towards combatting a broad range of infectious, chronic, and genetic disorders.

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