Hyaluronic acid as a marker for remodeling of bronchopulmonary system in patients with occupational pulmonary pathology

Abstract

Currently there is no convincing evidence concerning pathogenetic mechanisms of fibrous and sclerotic processes in pulmonary tissue as well as processes of bronchopulmonary system remodeling in patients with chronic obstructive pulmonary disease (COPD) of occupation etiology (OE).The purpose of the study was to identify relationship between the serum hyaluronic acid (HA) level and severity of obstructive pulmonary ventilation impairment according to spirometry data in subjects with COPD associated with the impact of silica-containing dust and chronic occupational non-obstructive (common) bronchitis (CONB) of occupational etiology.Materials and Methods. Patients (n = 153) with the diagnosis OE COPD (n = 92), OE CONB (n = 36) and healthy subjects participated in the study.Results. The study data demonstrated that serum HA level in patients with OE COPD and CONB was 3–5 times higher than that in healthy subjects (p = 0.0001). In patients with OE COPD HA concentration was significantly higher, than that in subjects with OE CONB (p = 0.039). Negative correlation between HA concentration and forced expiratory volume in 1 second value was observed (p = 0.006; R = –0.31). There was statistically significant positive correlation between HA level and disease duration (р = 0.021; R = 0.21).Conclusion. Serum HA level in patients with OE-related COPD and CONB may be used as a biomarker of fibrous and sclerotic process in pulmonary tissue, reflecting progression of obstruction and remodeling of small bronchi.