Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy

Chen, Jingxiao; Wang, Min; Tian, Huihui; Chen, Jinghua

doi:10.1016/j.colsurfb.2015.06.039

Cited by 32 publications

(20 citation statements)

References 37 publications

(32 reference statements)

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“…Therefore, it is of great signicance to modify HA to obtain HA hydrogels with stronger stability and better mechanical properties. HA can be modied by crosslinking, 10 graing, 11 linking with hydrophobic substances, 12 by forming polyionic complexes with polysaccharides, proteins or surfactants with opposite charges, 13 or by permeating networks to produce self-assembled aggregates, nanoparticles and gels. 14 Selin et al proved that the composite material composed of hyaluronic acid and natural polymer could be used as the reinforcement material of tissue engineering scaffolds, it was shown that such composite materials exhibited high thermal and mechanical stabilities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether

Xue

Chen

et al. 2020

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether

Xue

Chen

et al. 2020

RSC Adv.

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“…PH is also an amphiphilic polymer with hydrophilic (histidine) and hydrophobic (polyethylenimine) residues. sHH and PH self-assembled into sHH/PH nanoparticles through hydrophobic/hydrophilic interactions 14 , 19 .…”

Section: Resultsmentioning

confidence: 99%

“…Gellan gum was prepared into microspheres by using emulsification. We also synthesized short-chain hyaluronic acid-histidine (sHH) and polyethylenimine-histidine (PH) copolymers, both of which can self-assemble into nanoparticle and application as drug carrier 14 . The nano drug carriers were combined with doxorubicin (Dox) according to the principle of electrical property, forming sHH/PH/Dox nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent

Hsu

Tyan

Chien

et al. 2018

Sci Rep

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The purpose of this study was to develop a gellan gum-based multifunctional embolic agent. Calibrated spherical gellan gum and nanoparticle-containing gellan gum microspheres were prepared via water-in oil emulsification method. Self-assembled nanoparticles composed of short-chain hyaluronic acid and polyethylenimine as the doxorubicin carrier were prepared. The short-chain hyaluronic acid/polyethylenimine/ doxorubicin (sHH/PH/Dox) with the mean size was 140 ± 8 nm. To examine sHH/PH/Dox nanoparticle uptake into cells, the results confirmed that sHH/PH nanoparticles as drug carrier can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, sHH/PH/Dox merged into the gellan gum (GG) microspheres forming GG/sHH/PH/Dox microsphere. After a drug release experiment lasting 45 days, the amount of released doxorubicin from 285, 388, and 481 μm GG/sHH/PH/Dox microspheres were approximately 4.8, 1.8 and 1.1-fold above the IC50 value of the HepG2 cell. GG/sHH/PH/Dox microspheres were performed in rabbit ear embolization model and ischemic necrosis on ear was visible due to the vascular after 8 days. Regarding the application of this device in the future, we aim to provide better embolization agents for transcatheter arterial chemoembolization (TACE).

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“…LbL assemblies of the hyaluronic acid–L-histidine conjugate (HH) and the polyethylenimine–L-histidine conjugate (PH) at different weight ratios have also been developed for the controlled release of doxorubicin (DOX), a small molecular drug [ 43 ] ( Figure 6 ). The His moieties reduced the charge density of PEI, hence rendering it biocompatible.…”

Section: Biomedical Applications Of Lbl Pe Nano-assembliesmentioning

confidence: 99%

LbL Nano-Assemblies: A Versatile Tool for Biomedical and Healthcare Applications

Díez‐Pascual

Rahdar

2022

Nanomaterials

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Polyelectrolytes (PEs) have been the aim of many research studies over the past years. PE films are prepared by the simple and versatile layer-by-layer (LbL) approach using alternating assemblies of polymer pairs involving a polyanion and a polycation. The adsorption of the alternating PE multiple layers is driven by different forces (i.e., electrostatic interactions, H-bonding, charge transfer interactions, hydrophobic forces, etc.), which enable an accurate control over the physical properties of the film (i.e., thickness at the nanoscale and morphology). These PE nano-assemblies have a wide range of biomedical and healthcare applications, including drug delivery, protein delivery, tissue engineering, wound healing, and so forth. This review provides a concise overview of the most outstanding research on the design and fabrication of PE nanofilms. Their nanostructures, molecular interactions with biomolecules, and applications in the biomedical field are briefly discussed. Finally, the perspectives of further research directions in the development of LbL nano-assemblies for healthcare and medical applications are highlighted.

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Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy

Cited by 32 publications

References 37 publications

Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether

Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether

Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent

LbL Nano-Assemblies: A Versatile Tool for Biomedical and Healthcare Applications

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