Hyaluronic Acid and Periodontitis

Abstract

Hyaluronic acid (HA; synonyms- Hyaluronan, Hyaluronate) is a glycosaminoglycan found in the connective tissue of vertebrates. It is the most abundant glycosaminoglycan of higher molecular weight in the extracellular matrix of soft periodontal tissues. The use of HA in the treatment of inflammatory process is established in medical areas such as orthopedics, dermatology and ophthalmology. In the field of dentistry, it has shown anti-inflammatory and anti-bacterial effects in gingivitis and periodontitis therapy. Due to its tissue healing properties, it could be used as an adjunct to mechanical therapy in the treatment of periodontitis.

Hyaluronic Acid as an Adjunct After Scaling and Root Planing: A Prospective Randomized Clinical Trial

“…HA is a candidate for use in the restoration of periodontal integrity due to its complex interactions with the extracellular matrix and its components 44,45 . High‐molecular‐weight HA reduces proliferation of fibroblasts and lymphocytes in the epithelium in periodontal lesions 46 .…”

Hyaluronic Acid as an Adjunct to Scaling and Root Planing in Chronic Periodontitis. A Randomized Clinical Trail

“…HA plays an important role in post-inflammatory tissue regeneration, facilitating cell migration and differentiation during tissue formation and repair [36]. At present it is not possible to identify with certainty those patients who may possess some form of hyper-inflammatory trait.…”

Effect of hyaluronic acid on morphological changes to dentin surfaces and subsequent effect on periodontal ligament cell survival, attachment, and spreading

“…Their application is considered to support healing processes mainly by reducing inflammatory parameters, e.g., bleeding on probing (BOP) and probing depth (PD) [6]. More, recently, a variety of growth factors such as platelet-derived growth factor and enamel matrix derivatives have gained interest for clinical applications as bioactive substances in regenerative procedures in periodontology [7].…”