Hyaluronic acid ameliorates bladder hyperactivity via the inhibition of H<sub>2</sub>O<sub>2</sub>‐enhanced purinergic and muscarinic signaling in the rat

Yeh, Chung Hsin; Chiang, Han Sun; Chien, Chiang Ting

doi:10.1002/nau.20830

Cited by 20 publications

(19 citation statements)

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“…Recent studies in lower urinary tract symptom (LUTS) patients suggest that the obstruction of a bladder urothelial membrane and an increase of oxidative stress followed a bladder ischemia and inflammation may cause urinary dysfunction (37,38). Furthermore, it has been shown that that an intravesical administration of H 2 O 2 evokes immediately detrusor overactivity in anesthetized rats by continuous cystometrography, and oxidative stress induced by H 2 O 2 sensitizes the capsaicinsensitive C-fiber afferent pathway, thereby inducing detrusor overactivity (30,31). The present findings further support the hypothesis that ROS play a key role n the generation of inflammatory and overactive bladder.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, excess ROS generated endogenously can lead to lipid peroxidation, protein oxidization, and DNA damage in the bladder. Recent studies demonstrate that an intravesical injection of H 2 O 2 causes immediately detrusor overactivity in anesthetized rats, suggesting ROS show the stimulatory effect on the bladder afferent fibers directly and/or indirectly (30,31). However, the long-term effects of an intravesical injection of H 2 O 2 on structural and functional changes of the bladder have not been clarified.…”

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confidence: 99%

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A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

et al. 2013

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

et al. 2013

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“…In cyclophosphamide-induced cystitis in rats, there are substantial changes in both sympathetic and parasympathetic efferent nerves, which affect the afferent nervous input from the bladder; changes in parasympathetic innervation occur prejunctionally, while changes in sympathetic innervation postjunctionally [263]. It has been reported that hyaluronic acid reduced bladder hyperactivity by inhibiting H 2 O 2 -enhanced purinergic and muscarinic signalling [734].…”

Section: Detrusor Overactivitymentioning

confidence: 99%

Purinergic signalling in the urinary tract in health and disease

Burnstock

2013

Purinergic Signalling

140

149

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Purinergic signalling is involved in a number of physiological and pathophysiological activities in the lower urinary tract. In the bladder of laboratory animals there is parasympathetic excitatory cotransmission with the purinergic and cholinergic components being approximately equal, acting via P2X1 and muscarinic receptors, respectively. Purinergic mechanosensory transduction occurs where ATP, released from urothelial cells during distension of bladder and ureter, acts on P2X3 and P2X2/3 receptors on suburothelial sensory nerves to initiate the voiding reflex, via low threshold fibres, and nociception, via high threshold fibres. In human bladder t h e p u r i n e rg i c c o m p o n e n t o f p a r a s y m p a t h e t i c cotransmission is less than 3 %, but in pathological conditions, such as interstitial cystitis, obstructed and neuropathic bladder, the purinergic component is increased to 40 %. Other pathological conditions of the bladder have been shown to involve purinoceptor-mediated activities, including multiple sclerosis, ischaemia, diabetes, cancer and bacterial infections. In the ureter, P2X7 receptors have been implicated in inflammation and fibrosis. Purinergic therapeutic strategies are being explored that hopefully will be developed and bring benefit and relief to many patients with urinary tract disorders.

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“…In rat bladder, hyaluronic acid ameliorated H 2 O 2 -induced hyperactivity, possibly via the antioxidant activity and the inhibition of purinergic and muscarinic signaling pathway [83]. In rat vascular smooth muscle cells of the aorta, M 3 receptors were involved in heparin-dependent relaxation [32].…”

Section: Muscarinic Receptor and Extracellular Matrix Moleculesmentioning

confidence: 99%

Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects

Karakiulakis

Roth

2012

Mediators of Inflammation

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Muscarinic receptors are expressed by most cell types and mediate cellular signaling of their natural ligand acetylcholine. Thereby, they control numerous central and peripheral physiological organ responses to neuronal activity. In the human lung, muscarinic receptors are predominantly expressed by smooth muscle cells, epithelial cells, and fibroblasts. Antimuscarinic agents are used for the treatment of chronic obstructive pulmonary disease and to a lesser extent for asthma. They are primarily used as bronchodilators, but it is now accepted that they are also associated with anti-inflammatory, antiproliferative, and antiremodeling effects. Remodeling of the small airways is a major pathology in COPD and impairs lung function through changes of the extracellular matrix. Glycosaminoglycans, particularly hyaluronic acid, and matrix metalloproteases are among extracellular matrix molecules that have been associated with tissue inflammation and remodeling in lung diseases, including chronic obstructive pulmonary disease and asthma. Since muscarinic receptors have been shown to influence the homeostasis of glycosaminoglycans and matrix metalloproteases, these molecules may be proved valuable endpoint targets in clinical studies for the pharmacological exploitation of the anti-inflammatory and antiremodeling effects of muscarinic inhibitors in the treatment of chronic obstructive pulmonary disease and asthma.

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Hyaluronic acid ameliorates bladder hyperactivity via the inhibition of H₂O₂‐enhanced purinergic and muscarinic signaling in the rat

Abstract: These results indicate that hyaluronic acid treatment can ameliorate H(2)O(2)-induced bladder hyperactivity possibly via the antioxidant activity and the inhibition of activating purinergic and muscarinic signaling pathway.

Cited by 20 publications

References 21 publications

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

Purinergic signalling in the urinary tract in health and disease

Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects

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Hyaluronic acid ameliorates bladder hyperactivity via the inhibition of H2O2‐enhanced purinergic and muscarinic signaling in the rat

Abstract: These results indicate that hyaluronic acid treatment can ameliorate H(2)O(2)-induced bladder hyperactivity possibly via the antioxidant activity and the inhibition of activating purinergic and muscarinic signaling pathway.

Cited by 20 publications

References 21 publications

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

Purinergic signalling in the urinary tract in health and disease

Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects

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Hyaluronic acid ameliorates bladder hyperactivity via the inhibition of H₂O₂‐enhanced purinergic and muscarinic signaling in the rat