Hyaluronic acid accumulation and redistribution in rejecting rat kidney graft. Relationship to the transplantation edema.

Hällgren, Roger; Gerdin, Bengt; Tufveson, Gunnar

doi:10.1084/jem.171.6.2063

Cited by 85 publications

(84 citation statements)

References 34 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The synthesis ofa matrix rich in HA seems to be an important event during the early stages ofthe formation and remodelling of embryonic tissue and during wound repair (26). The matrix is thereby stabilized and cell infiltration and migration are stimulated (25)(26)(27)(28)(29). Thus, the early accumulation of HA and water in the myocardial interstitial tissue during infarction may facilitate the cell infiltration and scar formation.…”

Section: Discussionmentioning

confidence: 99%

Accumulation of hyaluronan and tissue edema in experimental myocardial infarction.

Waldenström¹,

Martinussen²,

Gerdin³

et al. 1991

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

Experimental myocardial infarction was induced in rats. The myocardial accumulation of hyaluronan (HA) and water during the development of infarction was measured. The extractable HA content of the infarcted area increased progressively from day 1 and on day 3 reached a threefold increase compared with the HA amounts in myocardium of sham operated controls. The relative water content of infarcted areas also increased progressively reaching a maximum value by day 3 and was strongly correlated with the HA accumulation. Affinity histochemistry visualized a thin rim of HA in the endoperimysium in healthy myocardium. By day 2 an interstitial edema with inflammatory cells was apparent. The widened endoperimysium stained extensively for HA. By its water-binding ability, interstitial accumulation of HA will contribute to the interstitial edema in infarcted myocardial tissue. An interstitial edema is likely to influence the electromechanical characteristics of the myocardium and facilitate reentry phenomena due to a loss of contact between muscle cells. The edema also induces an increased extracellular pressure and an altered myocardial wall compliance that might impair myocardial microcirculation. The findings are relevant to an understanding of the beneficial effect of hyaluronidase treatment in limiting cellular damage during myocardial ischemia. (J. Clin. Invest. 1991. 88:1622-1628

show abstract

Section: Discussionmentioning

confidence: 99%

Accumulation of hyaluronan and tissue edema in experimental myocardial infarction.

Waldenström¹,

Martinussen²,

Gerdin³

et al. 1991

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

show abstract

“…To resolve this question a similar investigation was performed in a series of rats receiving orthotopic kidney allografts, or syngeneic grafts in control animals. After allografting there was a progressive increase in the concentration of HYA to about twice the pretransplant values in the allograft after six days [30]. Localization studies with the biotin-labelled HYAbinding protein (HABP] showed that the overwhelming amount of HYA in the normal kidney was localized in the papillae, whilst virtually no HYA could be discerned in the cortex.…”

Section: Rejection Of Allograftsmentioning

confidence: 99%

Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation

Gerdin

Hällgren

1997

Journal of Internal Medicine

124

View full text Add to dashboard Cite

Gerdin B, Hällgren R (University Hospital, Uppsala, Sweden). Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation (Minisymposium: Hyaluronan). J Intern Med 1997; 242: 49–55. An increased tissue accumulation of HYA occurs in several human and experimental inflammatory conditions. Such is the case in sarcoidosis, idiopathic pulmonary fibrosis and farmer's lung in man, and experimental bleomycin‐induced lung damage in rats. Graft rejection in man and rats, experimental myocarditis in mice and myocardial infarction in rats follow the same pattern. Increased amounts of HYA also appear in gut luminal perfusion fluid in human inflammatory bowel disease. A transient accumulation of HYA is seen in wound healing, which is more sustained in fetuses. An increased accumulation of water and presentation of ligands for receptors on inflammatory cells are two consequences of the HYA accumulation.

show abstract

“…Several studies have demonstrated that hyaluronan is highly abundant in the interstitium of the renal inner medulla in contrast to the low amounts seen in other regions of the kidney (4,13,18). Figure 6 illustrates the high level of hyaluronan accumulation in the rat inner medulla as revealed by Alcian blue staining.…”

Section: Concentrating Model Driven By Renal Pelvic Wall Contractionsmentioning

confidence: 99%

Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechano-osmotic transducer

Knepper

Saidel

Hascall

et al. 2003

American Journal of Physiology-Renal Physiology

111

View full text Add to dashboard Cite

. Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechano-osmotic transducer. Am J Physiol Renal Physiol 284: F433-F446, 2003; 10.1152/ajprenal.00067.2002Although the concentrating process in the renal outer medulla is well understood, the concentrating mechanism in the renal inner medulla remains an enigma. The purposes of this review are fourfold. 1) We summarize a theoretical basis for classifying all possible steady-state inner medullary countercurrent concentrating mechanisms based on mass balance principles. 2) We review the major hypotheses that have been proposed to explain the axial osmolality gradient in the interstitium of the renal inner medulla. 3) We summarize and expand on the SchmidtNielsen hypothesis that the contractions of the renal pelvocalyceal wall may provide an important energy source for concentration in the inner medulla. 4) We discuss the special properties of hyaluronan, a glycosaminoglycan that is the chief component of a gel-like renal inner medullary interstitial matrix, which may allow it to function as a mechanoosmotic transducer, converting energy from the contractions of the pelvic wall to an axial osmolality gradient in the medulla. These considerations set the stage for renewed experimental investigation of the urinary concentrating process and a new generation of mathematical models of the renal concentrating mechanism, which treat the inner medullary interstitium as a viscoelastic system rather than a purely hydraulic system. glycosaminoglycans; renal pelvis; vasopressin; hyaluronan IN STATES OF FLUID DEPRIVATION or nonrenal water loss, the kidney can conserve water while maintaining excretion of solutes. It does this by concentrating the solutes in the urine to osmolalities that markedly exceed the osmolality of plasma. A large number of studies, exemplified by the data shown in Fig. 1, have demonstrated that the urinary concentrating process is associated with the generation of a corticomedullary osmolality gradient in the medullary tissue, oriented with the maximum osmolality in the deepest part of the inner medulla, i.e., at the papillary tip. The classic micropuncture studies of Gottschalk and Mylle (17) have established that the medullary hypertonicity is due to solute accumulation in all structures in the medulla, including loops of Henle, vasculature, and collecting ducts. The high medullary interstitial osmolality provides a driving force for osmotic water flow across the collecting ducts, which are rendered permeable to water through the action of vasopressin (33). The high water permeability allows osmotic equilibration of urine with the medullary interstitial fluid.In 1959, Kuhn and Ramel (43) proposed a model to explain concentration of solutes in the renal medulla Address for reprint requests and other correspondence: M. A. Knepper,

show abstract

Hyaluronic acid accumulation and redistribution in rejecting rat kidney graft. Relationship to the transplantation edema.

Cited by 85 publications

References 34 publications

Accumulation of hyaluronan and tissue edema in experimental myocardial infarction.

Accumulation of hyaluronan and tissue edema in experimental myocardial infarction.

Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation

Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechano-osmotic transducer

Contact Info

Product

Resources

About