Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects

Bukhari, Syed Nasir Abbas; Roswandi, Nur Liyana; Waqas, Muhammad; Habib, Haroon; Hussain, Fahad; Khan, Shahzeb; Sohail, Muhammad; Ramli, Nor Amlizan; Thu, Hnin Ei; Hussain, Zahid

doi:10.1016/j.ijbiomac.2018.09.188

Cited by 333 publications

(270 citation statements)

References 72 publications

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“…Several HA formulations have been developed specifically for applications in cosmetic [270] and ophthalmic corrective surgical applications (Table 5). HA ophthalmic visco-elastic devices are used in vitro retinal, anterior segment and glaucoma surgery, and corneal transplantation procedures in the eye and on its surface to prevent dehydration and to promote wound healing.…”

Section: Ha For Reconstructive Surgery and Cosmetic Applicationsmentioning

confidence: 99%

“…[271] Dermal filling with cross-linked HA such as Princess Filler is a viable treatment option for the correction of various soft tissue defects of the face resulting facial lipoatrophy, morphological asymmetry of the face, or debilitating depressed scars. [270,274] The longer residence time due to improved stability of high molecular weight cross-linked HAs such as Restyllane are also important performance indicators. [270,274] The longer residence time due to improved stability of high molecular weight cross-linked HAs such as Restyllane are also important performance indicators.…”

Section: Ha For Reconstructive Surgery and Cosmetic Applicationsmentioning

confidence: 99%

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Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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The aim of this study is to review developments in glycosaminoglycan and proteoglycan research relevant to cartilage repair biology and in particular the treatment of osteoarthritis (OA). Glycosaminoglycans decorate a diverse range of extracellular matrix and cell associated proteoglycans conveying structural organization and physico-chemical properties to tissues. They play key roles mediating cellular interactions with bioactive growth factors, cytokines, and morphogenetic proteins, and structural fibrillar collagens, cell interactive and extracellular matrix proteoglycans, and glycoproteins which define tissue function. Proteoglycan degradation detrimentally affects tissue functional properties. Therapeutic strategies have been developed to counter these degenerative changes. Neo-proteoglycans prepared from chondroitin sulfate or hyaluronan and hyaluronan or collagen-binding peptides emulate the interactive, water imbibing, weight bearing, and surface lubricative properties of native proteoglycans. Many neo-proteoglycans outperform native proteoglycans in terms of water imbibition, matrix stabilization, and resistance to proteolytic degradation. The biospecificity of recombinant proteoglycans however, provides precise attachment to native target molecules. Visco-supplements augmented with growth factors/therapeutic cells, hyaluronan, and lubricin (orthobiologicals) have the capacity to lubricate and protect cartilage, control inflammation, and promote cartilage repair and regeneration of early cartilage lesions and may represent a more effective therapeutic approach to the treatment of mild to moderate OA and deserve further study.Similar protective perineural net structures assembled from the lectican proteoglycan family and HA also occur in the CNS/PNS. These so called perineuronal nets are visualized by immunolocalization of MAb 1B5 (+) epitope in rat brain (e) and pericellular 1B5(+) epitope expression by isolated neurons (f). Scale bars 100 µm.

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Section: Ha For Reconstructive Surgery and Cosmetic Applicationsmentioning

confidence: 99%

Section: Ha For Reconstructive Surgery and Cosmetic Applicationsmentioning

confidence: 99%

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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“…In addition to its use in conventional medicine, in recent years HA has been commonly used in aesthetic medicine as filler and in the treatment of the signs of aging and in resolving skin blemishes [5,6]. Some features of facial aging are the development of facial lines and reduction of lip volume.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effect of Two Hyaluronic Acid Preparations on Fibroblast and Endothelial Cell Functions Related to Angiogenesis

Ciccone

Zazzetta²,

Morbidelli

2019

Cells

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Hyaluronic acid (HA) is used in substitutive and aesthetic medicine with various applications. Ultrapure absorbable HA (Bioregen ® ) and a mix of reticulated and free low molecular weight HA (Regenyal Idea Bioexpander ® ) (both provided by Regenyal Laboratories Srl, San Benedetto del Tronto (AP), Italy) represent a reliable hydrating device and skin filler, useful for skin blemishes, lines and wrinkles, and lip widening, respectively. The commercial products are known for their safety, but data on the molecular, cellular, and tissue responses are lacking. We aimed to evaluate the bioavailability and the pro-angiogenic features of the products Bioregen ® and Bioexpander ® in vitro on cultured endothelial cells (ECs) and dermal fibroblasts in vivo when injected into experimental animals. When added to fibroblasts and ECs, Bioexpander ® induced cell migration. The two HA preparations were well tolerated, while a transient proangiogenic behavior of Bioexpander ® , when implanted subcutaneously in mice, was found. The neovascular response was evident in the first week with higher levels of VEGF and FGF-2 before undergoing regression. In conclusion, our data strengthen the safety of HA synthetic preparations both in vitro and in vivo. Even if a proangiogenic response is documented, it is modest and transient, leading to tissue recovery and absence of an inflammatory infiltrate.

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“…They may temporarily occupy the body volume and cause limited local host tissue response (limited fibrogenic). Examples of type A fillers include sodium hyaluronate acid (HA), collagen, and acellular matrices (ACMs) …”

Section: Polymeric Injectable Fillersmentioning

confidence: 99%

“…Injectable filler based on sodium hyaluronate or hyaluronic acid (HA) has the largest number of products and is the most extensively used product at present. In 2018, around 80% of the injectable fillers in United States are hyaluronate‐based products .…”

Section: Polymeric Injectable Fillersmentioning

confidence: 99%

Polymeric injectable fillers for cosmetology: Current status, future trends, and regulatory perspectives

Zhao

Zhang

et al. 2019

J of Applied Polymer Sci

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Injectable fillers have become a vital part of cosmetology. A wide variety of injectable fillers are developed for either correction of facial wrinkles and folds or facial contouring. As the most popular filler products, polymeric injectable fillers represent a class of the most common implantable medical devices. This review is intended to not only present current filler products, but also share perspectives of future trends, development processes, and regulatory considerations for the next generation of fillers. First, currently approved polymeric injectable fillers are described in detail. Second, future trends of polymeric injectable fillers are discussed. Fillers based on the emerging technologies in tissue engineering and regenerative medicine with stimuli‐responsive or tunable properties, as well as device/drug combination products, are promising candidates. Third, fillers for cosmetology are different from traditionally recognized medical devices. As a result, the target population of such fillers is different from that of other implantable devices, leading to different user needs that impact their development processes. Last, product applications, regulatory requirements, device evaluation, characteristics, and difficulties for regulating filler products for minimally invasive cosmetology are reviewed. Both regulatory science and scientific supervision are needed for polymeric injectable fillers which are facing great opportunities as well as challenges. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48515.

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Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects

Cited by 333 publications

References 72 publications

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Comparison of the Effect of Two Hyaluronic Acid Preparations on Fibroblast and Endothelial Cell Functions Related to Angiogenesis

Polymeric injectable fillers for cosmetology: Current status, future trends, and regulatory perspectives

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