Hyaluronic Acid: A Natural Biopolymer

Schiller, Jürgen; Volpi, Nicola; Hrabárová, Eva; Šoltés, Ladislav

doi:10.1002/9781118164792.ch1

Cited by 15 publications

(16 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This has forced, for instance, the Baxter Healthcare Corp. (as well as many other companies) to recall many preparations of contaminated heparin [24] and significantly enhanced the interest in detailed heparin analysis [25] to monitor the presence of harmful components [26]. Not least, this is a convincing proof of the pharmacological activities of GAG [27].…”

Section: Chemical Structures Of Native Gagmentioning

confidence: 99%

Sulfated Glycosaminoglycans As Promising Artificial Extracellular Matrix Components to Improve the Regeneration of Tissues

Schnabelrauch¹,

Scharnweber²,

Schiller

2013

CMC

Self Cite

View full text Add to dashboard Cite

Glycosaminoglycans (GAG) such as hyaluronan (HA) or chondroitin/dermatan sulfate (CS/DS) occur in many connective tissues, for instance, in bone, cartilage and skin. Due to their significant water-binding capacity, GAG are essential for the biomechanical properties of these tissues. However, there is also increasing evidence that the sulfation of GAG does not occur at random, but a "sulfation code" exists that mediates the physiological functions of GAG. Thus, the biological properties of these biomacromolecules are strongly influenced by the degree of sulfation (ds) and the sulfate group distribution along the polymer. Therefore, certain GAG might also have interesting pharmacological properties. It is, thus, commonly accepted that GAG represent promising biomaterials in the field of tissue engineering as well as to design new bioactive materials for tissue repair and reconstruction. In this review we will focus on chemically sulfated GAG and provide a survey of these compounds on four different levels. First, we will provide an overview on chemical functionalization strategies of naturally occurring HA and CS/DS with special emphasis on regioselective methods to introduce a defined number of sulfate residues into the carbohydrate backbone. Second, chemical and biochemical methods to characterize the synthesized compounds will be introduced with the focus on methods based on nuclear magnetic resonance (NMR) and mass spectrometry (MS). In the third part, we will discuss the interaction of natural and chemically sulfated GAG with proteins and other biomolecules with regulatory functions. Additionally, biological consequences of these interactions regarding healing processes of skin and bone will be presented by discussing selected cell culture experiments. Finally, in vivo effects of GAG as components of artificial extracellular matrices will be discussed.

show abstract

Section: Chemical Structures Of Native Gagmentioning

confidence: 99%

Sulfated Glycosaminoglycans As Promising Artificial Extracellular Matrix Components to Improve the Regeneration of Tissues

Schnabelrauch¹,

Scharnweber²,

Schiller

2013

CMC

Self Cite

View full text Add to dashboard Cite

show abstract

“…The typical composition of these gels (for example Hyalgan, Ostenil-Tendon, SportVis, Synvisc, Synocrom) is an isotonic solution (150 mM NaCl, pH ~7.3 adjusted by buffer) containing 1% of sodium hyaluronate. There are several problems with this treatment, for example the rapid enzymatic degradation of HyA within the joints [31], the pain and the risk of infection during the injection procedure. Furthermore, during movement and under the weight of the patient's body, the synovial fluid could be squeezed outside the joints reducing the efficiency of the intra-articular treatments.…”

Section: Introductionmentioning

confidence: 99%

Magnetic hyaluronate hydrogels: preparation and characterization

Tóth

Veress

Szekeres

et al. 2015

Journal of Magnetism and Magnetic Materials

View full text Add to dashboard Cite

A novel soft way of hyaluronate (HyA) based magnetic hydrogel preparation was revealed. Magnetite nanoparticles (MNPs) were prepared by co-precipitation. Since the naked MNPs cannot be dispersed homogenously in HyA-gel, their surface was modified with natural and biocompatible chondroitin-sulfate-A (CSA) to obtain CSA-coated MNPs (CSA@MNPs). The aggregation state of MNPs and that loaded with increasing amount of CSA up to 1 mmol/g was measured by dynamic light scattering at pH~6. Only CSA@MNP with ≥0.2 mmol/g CSA content was suitable for magnetic HyA-gel preparation. Rheological studies showed that the presence of CSA@MNP with up to 2 g/L did not affect the hydrogel's rheological behaviour significantly. The results suggest that the HyA-based magnetic hydrogels may be promising formulations for future biomedical applications, e.g. as intra-articular injections in the treatment of osteoarthritis.

show abstract

“…Our research group has already used sodium hyaluronate as a viscosity-increasing and mucoadhesive component in a nasal formulation (Horvát el al., 2009). Due to the mucoadhesive properties of this biopolymer, sodium hyaluronate can enhance the permeability of drugs via mucosal tissues by increasing residence time on the site of absorption (Lim et al, 2000;Cho et al, 2003;Ludwig, 2005;Schiller et al, 2011).…”

Section: Nasal Delivery Of Drugs To the Systemic Circulation -Generalmentioning

confidence: 99%

Innovative pharmaceutical formulations and excipients for nasal delivery of drugs to target the systemic circulation

Kürti¹

View full text Add to dashboard Cite

Hyaluronic Acid: A Natural Biopolymer

Cited by 15 publications

References 128 publications

Sulfated Glycosaminoglycans As Promising Artificial Extracellular Matrix Components to Improve the Regeneration of Tissues

Sulfated Glycosaminoglycans As Promising Artificial Extracellular Matrix Components to Improve the Regeneration of Tissues

Magnetic hyaluronate hydrogels: preparation and characterization

Innovative pharmaceutical formulations and excipients for nasal delivery of drugs to target the systemic circulation

Contact Info

Product

Resources

About