Hyaluronate improves pain, physical function and balance in the geriatric osteoarthritic knee: a 6-month follow-up study using clinical tests

Sun, Shu-Fen; Hsu, Chin Wang; Hwang, Chiao-Wen; Hsu, Pei-Te; Wang, Jue‐Long; Tsai, Shin-Lung; Chou, Yi-Jiun; Hsu, Yuan-Nian; Huang, Chien-Ming; Wang, Yuling

doi:10.1016/j.joca.2006.01.010

Cited by 38 publications

(35 citation statements)

References 33 publications

(30 reference statements)

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“…While the patients in the present study initially exhibited pain similar to that found in other studies addressing the non-pharmacological treatment of osteoarthritis,32 33 some studies report higher mean values34 and others report lower mean values,35 36 which demonstrates the variability of this parameter 37. The reduction in pain in the EG was similar to that reported in other studies involving patients with knee osteoarthritis 34 36 38…”

Section: Discussionsupporting

confidence: 84%

Impact of cane use on pain, function, general health and energy expenditure during gait in patients with knee osteoarthritis: a randomised controlled trial

Jones

Silva

et al. 2011

Ann Rheum Dis

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Objective To assess the impact of daily cane use during gait in relation to pain, function, general health and energy expenditure among patients with knee osteoarthritis. Method Sixty-four patients were randomly assigned to an experimental group (EG) or control group (CG). The EG used a cane every day for 2 months, whereas the CG did not use a cane in this period. The fi rst outcome was pain and the second were function (Lequesne and WOMAC), general health (SF-36) and energy expenditure (gas analysis during the 6-minute walk test (6MWT) with and without a cane). Evaluations were performed at baseline, 30 and 60 days. Results The groups were homogeneous for all parameters at baseline. Compared with the CG, the EG signifi cantly improved pain (ES 0.18), functionLequesne (ES 0.13), some domains of SF-36 (role physical, ES 0.07 and bodily pain, ES 0.08) and distance on the 6MWT with the cane (ES 0.16). At the end of the 6MWT with the cane, the EG signifi cantly improved energy expenditure (ES 0.21), carbon dioxide production (ES 0.12) and metabolic equivalents (ES 0.15) compared with the CG.

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Section: Discussionsupporting

confidence: 84%

Impact of cane use on pain, function, general health and energy expenditure during gait in patients with knee osteoarthritis: a randomised controlled trial

Jones

Silva

et al. 2011

Ann Rheum Dis

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“…However, other studies have found higher averages [29], whereas others have described lower averages [26]. This clearly shows the variability in this parameter [30].…”

Section: Discussionmentioning

confidence: 54%

Evaluation of immediate impact of cane use on energy expenditure during gait in patients with knee osteoarthritis

Jones

Silva

et al. 2012

Gait & Posture

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“…We also compared the inhibitory effect of C60 on cartilage degeneration with that of HA in the rabbit model of OA. Hyaluronate, a component of glycoconjugates, shows high viscosity, has an important role in retaining moisture, and lubricates, coats, and protects joint functions (44,45). Intraarticular injection with this agent is widely recognized as a treatment to improve joint function in OA (45).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, in a rabbit model of OA produced by resection of both the medial meniscus and medial collateral ligament, we found that this compound significantly reduced articular cartilage degeneration. We also used the rabbit model of OA to compare the therapeutic effect of C60 on cartilage degeneration with that of sodium hyaluronate (HA), another compound that shows high viscosity, retains moisture, and has lubricating, coating, and jointprotecting functions (44,45). Our results indicate that C60 fullerene may be useful as a therapeutic agent in the 3308 YUDOH ET AL protection of articular cartilage against degeneration in patients with OA.…”

mentioning

confidence: 92%

Water‐soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down‐regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development

Yudoh

Shishido

Murayama

et al. 2007

Arthritis & Rheumatism

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Objective. Studies have shown the roles of oxidative stress in the pathogenesis of osteoarthritis (OA) and induction of chondrocyte senescence during OA progression. The aim of this study was to examine the potential of a strong free-radical scavenger, watersoluble fullerene (C60), as a protective agent against catabolic stress-induced degeneration of articular cartilage in OA, both in vitro and in vivo.Methods. In the presence or absence of C60 (100 M), human chondrocytes were incubated with interleukin-1␤ (10 ng/ml) or H 2 O 2 (100 M), and chondrocyte activity was analyzed. An animal model of OA was produced in rabbits by resection of the medial meniscus and medial collateral ligament. Rabbits were divided into 5 subgroups: sham operation or treatment with C60 at 0.1 M, 1 M, 10 M, or 40 M. The left knee joint was injected intraarticularly with watersoluble C60 (2 ml), while, as a control, the right knee joint received 50% polyethylene glycol (2 ml), once weekly for 4 weeks or 8 weeks. Knee bone and cartilage tissue were prepared for histologic analysis. In addition, in the OA rabbit model, the effect of C60 (10 M) on degeneration of articular cartilage was compared with that of sodium hyaluronate (HA) (5 mg/ml).Results. C60 (100 M) inhibited the catabolic stress-induced production of matrix-degrading enzymes (matrix metalloproteinases 1, 3, and 13), downregulation of matrix production, and apoptosis and premature senescence in human chondrocytes in vitro.In rabbits with OA, treatment with water-soluble C60 significantly reduced articular cartilage degeneration, whereas control knee joints showed progression of cartilage degeneration with time. This inhibitory effect was dose dependent, and was superior to that of HA. Combined treatment with C60 and HA yielded a significant reduction in cartilage degeneration compared with either treatment alone. Conclusion.The results indicate that C60 fullerene is a potential therapeutic agent for the protection of articular cartilage against progression of OA.During the development of osteoarthritis (OA), mechanical and chemical stresses on articular cartilage change the stable cellular activities of chondrocytes and stimulate the production of growth factors and matrix proteins as well as inflammation mediators (1-4). It is well known that catabolic-stressed chondrocytes produce excess amounts of reactive oxygen species (ROS) (superoxide, nitric oxide, hydrogen peroxide, and peroxynitrite) as well as proinflammatory cytokines and chemokines (4-9).Studies have provided ample confirmation of the generation of ROS and the depletion of cellular antioxidants in degenerated articular cartilage (8-10). Numerous reports have indicated that the degeneration of articular cartilage is partially mediated by oxygenderived free radicals (8-12). Kurz et al reported that the extent of mechanical stress on articular cartilage is sufficient to stimulate an excess production of ROS from chondrocytes, leading to depolymerization of hyaluronic acid and chondrocyte death (11,12). Similarly, Gree...

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Hyaluronate improves pain, physical function and balance in the geriatric osteoarthritic knee: a 6-month follow-up study using clinical tests

Abstract: Significant improvement in pain, physical function and balance tests was demonstrated after five weekly Artzal injections in geriatric patients with knee OA. The effect had rapid onset at 1 week and may last for 6 months.

Cited by 38 publications

References 33 publications

Impact of cane use on pain, function, general health and energy expenditure during gait in patients with knee osteoarthritis: a randomised controlled trial

Impact of cane use on pain, function, general health and energy expenditure during gait in patients with knee osteoarthritis: a randomised controlled trial

Evaluation of immediate impact of cane use on energy expenditure during gait in patients with knee osteoarthritis

Water‐soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down‐regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development

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