2006
DOI: 10.1016/j.jmb.2006.02.077
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Hyaluronan: The Local Solution Conformation Determined by NMR and Computer Modeling is Close to a Contracted Left-handed 4-Fold Helix

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Cited by 104 publications
(127 citation statements)
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“…8 The GLYCAM06 method predicted w I in the CN 2 model to be 118 more negative than in the HA 2 model (u I was unaltered), which is in close agreement with this experimental data and similar to a previous simulation prediction 15 using the GLYCAM93 59 paramater set. Cluster analysis of the CN 2 and HA 2 trajectories supported this finding, the (approximate) experimentally observed 3D-structural perturbation caused by hexosamine 4-epimerization can be seen graphically to be reproduced in Figure 7A.…”
Section: Comparison Of Computed and Experimental Disaccharide Conformsupporting
confidence: 86%
See 1 more Smart Citation
“…8 The GLYCAM06 method predicted w I in the CN 2 model to be 118 more negative than in the HA 2 model (u I was unaltered), which is in close agreement with this experimental data and similar to a previous simulation prediction 15 using the GLYCAM93 59 paramater set. Cluster analysis of the CN 2 and HA 2 trajectories supported this finding, the (approximate) experimentally observed 3D-structural perturbation caused by hexosamine 4-epimerization can be seen graphically to be reproduced in Figure 7A.…”
Section: Comparison Of Computed and Experimental Disaccharide Conformsupporting
confidence: 86%
“…Recent advances in isotopic labeling and material purification have facilitated determination of aqueous 3D-models for representative oligosaccharides in three of the four glycosaminoglycan sub-families (hyaluronan, 8 heparin, [9][10][11] and chondroitin/dermatan [12][13][14] ) by nuclear magnetic resonance (NMR) spectroscopy. Currently, however, only small glycosaminoglycan fragments are amenable to detailed NMR studies due to severe resonance overlap.…”
Section: Introductionmentioning
confidence: 99%
“…Recent structural work in aqueous solution has suggested that an exchange between hydrogen bonds and water molecules is the preferred explanation. This leads to a locally dynamic structure that is on average a contracted fourfold helix in solution [14], which is similar to the sodium hyaluronate x-ray diffraction refinement performed under physiological conditions [9]. Rheological and scattering studies have concluded that HA chains are semiflexible in solution.…”
Section: Structural and Physical Studiessupporting
confidence: 65%
“…Thus, several helical conformations of this polysaccharide (two-, three-and fourfold) have been observed. [6,7] As a principal constituent of the extracellular matrix, hyaluronic acid contributes significantly to cell proliferation and migration. By retaining a large amount of water, this polysaccharide is able to control tissue hydration.…”
Section: Introductionmentioning
confidence: 99%