Hyaluronan stimulates transformation of androgen-independent prostate cancer

Lin, Shi-Lung; Chang, Donald C.; Ying, Shao‐Yao

doi:10.1093/carcin/bgl134

Cited by 51 publications

(77 citation statements)

References 38 publications

(69 reference statements)

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“…A recent study revealed that the essential role of miR-19 was in mediating the oncogenic activity of miR-17-92, and implicated the functional diversity of mir-17-92 components as the molecular basis for its pleiotropic effects during tumorigenesis (Olive et al, 2009). miR-146 was found to be more consistently downregulated in androgen-independent PC cell lines than in androgen-dependent cell lines (Lin et al, 2007). Interestingly, miR-146 was also shown to inhibit the translation of the SDF-1 receptor CXCR4 (Labbaye et al, 2008).…”

Section: Prostate Cancer Mirnasmentioning

confidence: 97%

Expression profile analysis reveals putative prostate cancer-related microRNAs

Song

Liu²,

Pan³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Annotation of prostate cancer (PC) genomes provides a foundation for discoveries that can improve the understanding and treatment of the disease. Therefore, in the present study, we used the Student t-test to identify differentially expressed PC-related mRNAs and microRNAs (miRNAs). Then, we performed interrelated mapping of miRNA target genes between abnormally expressed mRNAs and miRNAs, and explored mRNA-target miRNA interrelated pairs to explain the biological functions of miRNA during the progression of PC, thus revealing the occurrence of miRNA-mediated PC. After Gene Set Functional Similarity analysis, we obtained 20 abnormal PC-related candidate miRNAs, including hsa-miR-26a, hsa-miR-152, hsa-miR19a, hsa-miR-30c, hsa-miR-19b, and hsa-miR-146b-5p, among others. These results suggest that it may be possible to predict the clinical behavior of prostate cancer based on gene expression analysis.

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Section: Prostate Cancer Mirnasmentioning

confidence: 97%

Expression profile analysis reveals putative prostate cancer-related microRNAs

Song

Liu²,

Pan³

et al. 2013

Genet. Mol. Res.

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“…mir-146a functions as a tumor suppressor gene www.rnajournal.org 419 vertebrate models with special RNAi activities (Lin et al 2006(Lin et al , 2007. Several transgenic loss-of-gene-function zebrafish, chicken, and mice have been established for studying various human diseases and neuropathological disorders, using this intronic miRNA expression system (Lin et al 2006).…”

Section: Confirmation Of Microarrayidentified Mirna Expressions In Humentioning

confidence: 99%

“…The identical sequences were also identified in human, indicating that this miRNA family might target the same genes conserved in humans (http://microrna.sanger.ac.uk). One of the major target genes of mir-146a, ROCK1, was recently reported to be highly involved in the transformation of HRPC and metastasis in vivo and in HRPC-derived PC3 cells (Lin et al 2007). In >70% of advanced prostate cancer patients, hyaluronan (HA-an extracellular disaccharide matrix polymer) frequently bound to its receptors (CD168 and CD44) and then stimulated the activation of Rho-activated protein kinase (ROCK)-mediated signal transduction pathways.…”

Section: Introductionmentioning

confidence: 99%

“…Second, HA-activated ROCK could phosphorylate its linker molecule, Gab1, and promoted the membrane localization of both Gab1 and CD168/CD44 for the activation of phosphatidylinositol-(3,4,5)P 3 kinases (PI3K). This activation of PI3K further converted phosphatidylinositol (PtdIns)-(4,5)P 2 to PtdIns-(3,4,5)P 3 (IP3), subsequently leading to the activation of Akt/mTOR/eIF4E signal transduction (Lin et al 2007). Activation of the Akt/ mTOR/eIF4E signaling has been often reported to increase malignant transformation and drug resistance in HRPC (Rodriguez-Viciana et al 1996;De Benedetti and Graff 2004).…”

Section: Introductionmentioning

confidence: 99%

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Loss of mir-146a function in hormone-refractory prostate cancer

Lin¹,

Chiang²,

Chang³

et al. 2008

RNA

354

249

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The pattern of microRNA (miRNA) expression is associated with the degree of tumor cell differentiation in human prostate cancer. MiRNAs bind complementarily to either oncogenes or tumor suppressor genes, which are consequently silenced, resulting in alterations of tumorigenecity. We have detected eight down-regulated and three up-regulated known miRNAs in androgen-independent human prostate cancer cells compared to those in androgen-dependent cells, using miRNA microarray analyses. These identified miRNAs showed the same expression patterns in hormone-refractory prostate carcinomas (HRPC) compared to androgen-sensitive noncancerous prostate epithelium as determined by fluorescent in situ hybridization assays in human prostate cancer tissue arrays. One of the eight down-regulated miRNAs, mir-146a, was selected and constitutively expressed to examine its effects on suppression of prostate cancer transformation from androgen-dependent to -independent cells as determined by in vitro tumorigenecity assays. Transfection of mir-146a, which perpetually express the miRNA, suppressed >82% of the expression of the targeted protein-coding gene, ROCK1, in androgen-independent PC3 cells, consequently markedly reducing cell proliferation, invasion, and metastasis to human bone marrow endothelial cell monolayers. Given that ROCK1 is one of the key kinases for the activation of hyaluronan (HA)-mediated HRPC transformation in vivo and in PC3 cells, mir-146a may function as a tumor-suppressor gene in modulating HA/ROCK1-mediated tumorigenecity in androgen-dependent prostate cancer.

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“…Hyaluronic acid (HA) is an extracellular matrix (ECM) polymer and is frequently localized in the stroma of solid tumors, which is synthesized by stromal fibroblasts in response to paracrine factors produced by tumor cells (6). HA serves an important role in cellular events, including cell migration, gene expression, signaling, proliferation, motility, adhesion, metastasis and morphogenesis (7,8).…”

Section: Introductionmentioning

confidence: 99%

Upregulation of hyaluronan-mediated motility receptor in hepatocellular carcinoma predicts poor survival

Liao

Li³

et al. 2015

Oncology Letters

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Abstract. Hepatocellular carcinoma (HCC) is one of the most common types of cancer across the world. Hyaluronic acid (HA) has been reported to serve an important role in tumor extension, progression, migration and invasion. In addition, the receptor for HA-mediated motility (RHAMM) has been demonstrated to be overexpressed in different types of cancer. However, whether the upregulation of RHAMM contributes to hepatocarcinogenesis of HCC remains unclear. The present study examined the RHAMM expression in 187 HCC patients by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC). RHAMM expression was significantly upregulated in liver cancer tissues compared with that observed in adjacent normal liver tissues. The IHC analysis demonstrated that RHAMM was overexpressed in 18 (72.0%) of the 25 HCC tissues. Furthermore, overexpression of RHAMM was associated with tumor-node-metastasis (TNM), the presence of vascular invasion and recurrence. Notably, the present study indicated that the overexpression of RHAMM was closely associated with the shorter disease-free and overall survival, so it may be a potential independent predictor for disease-free and overall survival of HCC patients. In conclusion, the upregulation of RHAMM is associated with HCC progression and prognosis; and it may be a potential independent predictor of disease-free and overall survival of HCC following surgical resection. IntroductionLiver cancer is one of the most common neoplasms worldwide, and hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer and accounts for 70-85% of all cases (1), ranking the sixth most common malignant tumors worldwide (2). More than 600,000 people lose their lives due to HCC every year (3), and HCC is the third most frequent cause of cancer-associated mortality (4). Previous studies have demonstrated that the incidence rate of HCC has been increasing. Surgical resection and liver-transplantation are superior therapeutic methods for HCC compared with other treatments, including radiofrequency ablation (RFA), transarterial chemoembolization (TACE) and chemotherapy, the treatment outcomes remain unsatisfactory owing to the high recurrence rate and high fatality rate of HCC (2). If HCC was detected and diagnosed earlier, surgical resection and liver-transplantation would result in an improved curative effect, therefore improving the disease-free and overall survival. The serum levels of α-fetoprotein (AFP) and ultrasonography (US) are widely used to screen for and assess HCC throughout the world. However, the sensitivity and specificity of AFP for HCC diagnosis and surveillance have certain limitations; US depends on the operator's skill, and clinicians are not always able to distinguish HCC clearly from other nodules (5). Consequently, novel potential serum biomarkers are required for prognosis and metastatic recurrence of HCC.Hyaluronic acid (HA) is an extracellular matrix (ECM) polymer and is frequently localized in the stroma of solid tumors, which is s...

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Hyaluronan stimulates transformation of androgen-independent prostate cancer

Cited by 51 publications

References 38 publications

Expression profile analysis reveals putative prostate cancer-related microRNAs

Expression profile analysis reveals putative prostate cancer-related microRNAs

Loss of mir-146a function in hormone-refractory prostate cancer

Upregulation of hyaluronan-mediated motility receptor in hepatocellular carcinoma predicts poor survival

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