Hyaluronan-Induced Cosmetic Reconstruction of the Nostril

Abstract

Tissue loss of the nostrils presents a considerable surgical challenge due to the greatly reduced availability of local tissue within such a peculiar anatomical region. The traditional reconstructive methods, such as direct suture, secondary healing, skin grafts, and local skin flaps, have shown poor provision of desirable cosmetic outcomes in this area. The authors propose an innovative and alternative method of cosmetic reconstruction of small skin defects of the nostril based on a hyaluronan-induced skin regeneration. Such a procedure allowed the healing of relatively large areas of skin loss with the formation of a truly regenerated tissue whose clinical features closely resemble those of the local normal skin. Nevertheless, the proposed procedure is lengthy and time-consuming and requires high levels of cooperation from patients. In our practice, the hyaluronan-induced skin regeneration is now considered the first choice for cosmetic reconstruction of small defects of the nostril in needy patients.

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

“…9-10 Clinically, HA has been used in several applications, including ophthalmology as a drug delivery system, 11-12 in osteoarthritis for viscosupplementation, 13-15 and as a dermal filler. 16-17 …”

One-stage reconstruction of extensive exposed tibia on malnourished patient using single-layer Integra and amino acid supplements: A case report and literature review

“…In other words, flap reconstruction may be inappropriate for flap reconstruction. [5] In this study, we present a case of a 66-year-old malnourished male who sustained a sizable tibia-exposed wound. Successful wound healing was achieved through the integration of nutritional supplements, negative pressure wound therapy (NPWT), and dermal substitutes, combined with skin grafts in a one-stage reconstruction.…”

Prasterone in the treatment of mild to moderate urge incontinence: an observational study

“…International guidelines support the treatment of vulvar and vaginal atrophy either with local moisturizing or lubricating agents in less severe cases or with local or systemic hormonal therapies in more severe cases as long as there are no contraindications 3 . Among the local moisturizing or lubricating agents available, hyaluronic acid is the one mostly used in both gynecological and nongynecological fields 4-6 . Hyaluronic acid is a fundamental component of the extracellular matrix, and its water-binding property provides a lubrication and moisturizing effect on human tissue, such as the vulva and vagina vestibule 5,7 .…”

“…3 Among the local moisturizing or lubricating agents available, hyaluronic acid is the one mostly used in both gynecological and nongynecological fields. [4][5][6] Hyaluronic acid is a fundamental component of the extracellular matrix, and its water-binding property provides a lubrication and moisturizing effect on human tissue, such as the vulva and vagina vestibule. 5,7 For this reason, it is often prescribed in the clinical practice of our hospitals.…”