Hyaluronan-estradiol nanogels as potential drug carriers to target ER+ breast cancer cell line

Paoletti, L.; Zoratto, Nicole; Benvenuto, Monica; Nardozi, Daniela; Angiolini, Valentina; Mancini, Patrizia; Masuelli, Laura; R, Bei; Frajese, Giovanni Vanni; Matricardi, Pietro; Nalli, M.; Meo, Chiara Di

doi:10.1016/j.carbpol.2023.120900

Cited by 6 publications

(2 citation statements)

References 48 publications

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“…Further, the morphology of the PAAbCH/chitosan nanosystems was observed by transmission electron microscopy (TEM) using a Philips Morgagni268D (FEI, Eindhoven Netherlands) at an accelerating voltage of 80 kV; 10 μL of PAAbCH/chitosan suspension was negatively stained as previously described [ 39 ]. Digital images were taken using Mega View imaging software.…”

Section: Methodsmentioning

confidence: 99%

Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications

Viola,

Migliorini,

Ziarelli

et al. 2023

JFB

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The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process.

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Section: Methodsmentioning

confidence: 99%

Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications

Viola,

Migliorini,

Ziarelli

et al. 2023

JFB

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show abstract

“… 159 Chittasupho et al 160 demonstrated that encapsulating DOX using a LFC131 peptide-modified polyamidoamine dendrimer led to the targeting and inhibition of CXCR4 on the surface of ER+ BC cells. Paoletti et al 161 proposed an innovative nano-delivery system based on hyaluronic acid involving a biologically active endogenous anionic polysaccharide functionalized with estradiol to produce an amphiphilic derivative, which can form soft NPs or nanohydrogels in water. The researchers investigated the adsorption of hydrophobic molecules by these estradiol-nanohydrogels through curcumin and docetaxel loading, and both inhibited the growth of ER+ BC.…”

Section: Therapeutic Nps Against Er-positive Bcbmmentioning

confidence: 99%

Nanoparticles for the Treatment of Bone Metastasis in Breast Cancer: Recent Advances and Challenges

Yu,

Zhu

2024

IJN

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Although the frequency of bone metastases from breast cancer has increased, effective treatment is lacking, prompting the development of nanomedicine, which involves the use of nanotechnology for disease diagnosis and treatment. Nanocarrier drug delivery systems offer several advantages over traditional drug delivery methods, such as higher reliability and biological activity, improved penetration and retention, and precise targeting and delivery. Various nanoparticles that can selectively target tumor cells without causing harm to healthy cells or organs have been synthesized. Recent advances in nanotechnology have enabled the diagnosis and prevention of metastatic diseases as well as the ability to deliver complex molecular “cargo” particles to metastatic regions. Nanoparticles can modulate systemic biodistribution and enable the targeted accumulation of therapeutic agents. Several delivery strategies are used to treat bone metastases, including untargeted delivery, bone-targeted delivery, and cancer cell-targeted delivery. Combining targeted agents with nanoparticles enhances the selective delivery of payloads to breast cancer bone metastatic lesions, providing multiple delivery advantages for treatment. In this review, we describe recent advances in nanoparticle development for treating breast cancer bone metastases.

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Hyaluronic acid/dextran-based polymeric micelles co-delivering ursolic acid and doxorubicin to mitochondria for potentiating chemotherapy in MDR cancer

Guo,

Yang,

Zhang

et al. 2024

Carbohydrate Polymers

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Hyaluronan-estradiol nanogels as potential drug carriers to target ER+ breast cancer cell line

Cited by 6 publications

References 48 publications

Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications

Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications

Nanoparticles for the Treatment of Bone Metastasis in Breast Cancer: Recent Advances and Challenges

Hyaluronic acid/dextran-based polymeric micelles co-delivering ursolic acid and doxorubicin to mitochondria for potentiating chemotherapy in MDR cancer

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