Hyaluronan decreases peritoneal fluid absorption: Effect of molecular weight and concentration of hyaluronan

Wang, Tao; Cheng, Hui-Hong; Heimbürger, Olof; Chen, Chi; Waniewski, Jacek; Bergström, Jonas; Lindholm, Bengt

doi:10.1046/j.1523-1755.1999.00279.x

Cited by 31 publications

(30 citation statements)

References 34 publications

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“…Structures of importance for water reabsorption are separated by the HA‐rich matrix, which alters transport properties. Besides changing the transport distances, this ‘functional oedema’ may also change the interstitial hydrostatic pressure (Zawieja et al 1992; Wang et al 1998, 1999). As a consequence, the low papillary HA in the gerbil and further reduction during water loading would facilitate water reabsorption and thereby reduce the diuretic response.…”

Section: Discussionmentioning

confidence: 99%

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Göransson

Johnsson²,

Nylander

et al. 2002

The Journal of Physiology

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Our previous studies in rats have suggested a role for renomedullary hyaluronan (HA) in water homeostasis. The gerbil is known for its unique ability to conserve water. In the present study renal papillary and intestinal HA were compared between groups of anaesthetized gerbils and rats before and after up to 6 h of i.v. water loading. Baseline papillary HA in gerbils was only 37 % of that in the rat. Water loading in rats increased the papillary HA content. Elevation was maximal (+27 %, P < 0.05) after 2 h of water loading and then declined to control levels after 6 h of water loading (+3 %, n.s.). In contrast, the gerbil responded with a decreased papillary HA content during water loading. The depression was maximal after 2 h (‐49 %, P < 0.05) and was still 41 % below the control values after 6 h (P < 0.05). The urine flow rate increased rapidly in the rat and its maximum, 21 times above the control level (P < 0.05), occurred at the HA peak, i.e. after 2 h of water loading while in the gerbil, the urine flow rate increased slowly and slightly and was only six times above control values after 6 h of water loading (P < 0.05). The HA content along the intestine was similar in the two species: lowest in the duodenum and jejunum and highest in the distal colon. To conclude, in the rat, the elevation of papillary interstitial HA during acute water loading would counteract water reabsorption by changing the physico‐chemical characteristics of the interstitial matrix favouring rapid water diuresis. This would work as a complement to the powerful regulation by ADH. The gerbil has a diametrically different regulation of papillary HA turnover during water loading. The decreased papillary HA level during water loading and the slow and small diuretic response may represent a genetic difference in adaptation to enhance the ability to conserve water in an arid environment.

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Section: Discussionmentioning

confidence: 99%

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Göransson

Johnsson²,

Nylander

et al. 2002

The Journal of Physiology

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“…In line with the idea that HA decreases water transport are the reports by Wang et al . (1998, 1999) showing that an i.p. injection of HA decreases peritoneal fluid absorption.…”

Section: Discussionmentioning

confidence: 99%

Renal cortical accumulation of hyaluronan in adult rats exposed neonatally to angiotensin‐converting enzyme inhibition

Nilsson

Johnsson

Friberg

et al. 2001

Acta Physiologica Scandinavica

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Neonatal inhibition of the renin-angiotensin system [angiotensin-converting enzyme (ACE) inhibition] in the rat results in long-term abnormal renal morphology and function, including interstitial inflammation and fibrosis. Hyaluronan (hyaluronic acid, HA) has pathological implications in inflammatory diseases and renal ischaemia-reperfusion injury. The present study aimed at determining if renal cortical HA in the adult rat is correlated to the abnormal morphology and function in rats treated neonatally with the ACE inhibitor enalapril. In adult control rats (23 weeks old), the cortical HA content was very low [about 5 microg g(-1) dry weight (d.w.)] and about 1% of the papillary HA content. In rats treated neonatally with enalapril (days 3-13), the cortical HA level was 15 times that in control rats already at 21 days after birth, and it persisted at this level during adulthood (at 23 weeks). At 13 weeks the enalapril-treated animals showed markedly reduced ability (-53%) to concentrate urine during 24-h thirst provocation. At 21 days as well as at 23 weeks the enalapril-treated kidneys displayed morphological changes, such as papillary atrophy, dilation of the tubules and cellular infiltration of the cortical tissue. Histochemical staining confirmed the HA quantification assay and revealed a patchy staining for HA located in the same regions as the infiltrating cells. In conclusion, neonatal treatment with the ACE inhibitor enalapril results in renal morphological and functional abnormalities during adulthood. Cortical HA levels are already seriously elevated at day 21 and coexist with infiltrating cells. Besides the known effects of angiotensin II in development, the accumulation of HA in these kidneys may be involved in the genesis of at least the cortical abnormalities in enalapril-treated animals because of the proinflammatory effects and water-binding properties of HA.

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“…HMW-HA has the ability to trap large amounts of water, thus possessing biophysical properties that serve to lubricate, hydrate, or space-fill tissues such as joints and connective tissue ( 13 , 95 ). Its hydrophilic attributes also allow it to act as a molecular sieve and affect fluid absorption rates to and from tissue through changes in its concentration ( 96 ). HMW-HA possesses biomechanical properties, and none more so is this evident than during development.…”

Section: The Opposing Effects Of Native Ha Versus Ha Fragments On Ecmmentioning

confidence: 99%

Hyaluronan â€“ A Functional and Structural Sweet Spot in the Tissue Microenvironment

2015

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Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture, physical properties, and matrix composition result in changes in biomechanical and biochemical cellular signaling. The dynamics of pericellular and extracellular matrices, including matrix protein, proteoglycan, and glycosaminoglycan modification are continually emerging as essential regulatory mechanisms underlying cellular and tissue function. Nevertheless, the impact of matrix organization on inflammation and immunity in particular and the consequent effects on tissue healing and disease outcome are arguably under-studied aspects of adaptive stress responses. Herein, we review how the predominant glycosaminoglycan hyaluronan (HA) contributes to the structure and function of the tissue microenvironment. Specifically, we examine the evidence of HA degradation and the generation of biologically active smaller HA fragments in pathological settings in vivo. We discuss how HA fragments versus nascent HA via alternate receptor-mediated signaling influence inflammatory cell recruitment and differentiation, resident cell activation, as well as tumor growth, survival, and metastasis. Finally, we discuss how HA fragmentation impacts restoration of normal tissue function and pathological outcomes in disease.

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Hyaluronan decreases peritoneal fluid absorption: Effect of molecular weight and concentration of hyaluronan

Cited by 31 publications

References 34 publications

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Renal cortical accumulation of hyaluronan in adult rats exposed neonatally to angiotensin‐converting enzyme inhibition

Hyaluronan â€“ A Functional and Structural Sweet Spot in the Tissue Microenvironment

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