Hyaluronan-Based Nanohydrogels as Effective Carriers for Transdermal Delivery of Lipophilic Agents: Towards Transdermal Drug Administration in Neurological Disorders

Son, Seong Uk; Lim, Jaewoo; Kang, Taejoon; Jung, Juyeon; Lim, Eun‐Kyung

doi:10.3390/nano7120427

Cited by 32 publications

(20 citation statements)

References 45 publications

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“…This phenomenon can be explained by the strengthening of the hydrogel by the presence of PDRN, which acted as a semi-interpenetrating polymer network 35 . The homogeneous dispersion of PDRN led to an increased stress transfer from polymer chains to PDRN, similar to the effect of nano fillers such as carbon nanotubes, cellulose nano crystals, and nano clay 36 . Although the strength of PDRN itself is very low compared with strengthening fillers such as carbon nanotubes or nano crystals, the high degree of physical entanglement of the two polymer materials at high Alg concentration was sufficient to slightly increase the strength of the hydrogel.…”

Section: Resultsmentioning

confidence: 83%

Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing

Shin

Park

Choi

et al. 2020

Sci Rep

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Patients with diabetes experience delayed wound healing because of the uncontrolled glucose level in their bloodstream, which leads to impaired function of white blood cells, poor circulation, decreased production and repair of new blood vessels. Treatment using polydeoxyribonucleotide (PDRN), which is a DNA extracted from the sperm cells of salmon, has been introduced to accelerate the healing process of diabetic wounds. To accelerate the wound-healing process, sustained delivery of PDRN is critical. In this study, taking advantage of the non-invasive gelation property of alginate, PDRN was loaded inside the hydrogel (Alg-PDRN). The release behavior of PDRN was altered by controlling the crosslinking density of the Alg hydrogel. The amount of PDRN was the greatest inside the hydrogel with the highest crosslinking density because of the decreased diffusion. However, there was an optimal degree of crosslinking for the effective release of PDRN. In vitro studies using human dermal fibroblasts and diabetes mellitus fibroblasts and an in ovo chorioallantoic membrane assay confirmed that the Alg-PDRN hydrogel effectively induced cell proliferation and expression of angiogenic growth factors and promoted new blood vessel formation. Its effectiveness for accelerated diabetic wound healing was also confirmed in an in-vivo animal experiment using a diabetic mouse model.

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Section: Resultsmentioning

confidence: 83%

Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing

Shin

Park

Choi

et al. 2020

Sci Rep

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“…In recent years, it has been widely used in nanoformulations. [23][24][25] Due to the insoluble properties of DAS and ROZ and the aggressive characteristics of tumor cells. Hyaluronic acid (HA) and DAS are bonded by a pHsensitive ester bond to form an HA-DAS polymer.…”

Section: Introductionmentioning

confidence: 99%

A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy

Wang¹,

Zhang²,

Zeng³

et al. 2021

IJN

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The metastasis of breast cancer is an important cause of tumor recurrence. This study highlights that tyrosine kinase inhibitors dasatinib (DAS) and rosiglitazone (ROZ) inhibit tumor growth and reduce the occurrence of tumor cell metastasis. Due to the poor water solubility, short half-time in the body of DAS and ROZ, which increases the difficulty of tumor treatment, as well as the demand for nano-drug delivery systems for organ-specific therapies. Methods: Hyaluronic acid (HA) and DAS are bonded by a pH-sensitive ester bond to form an HA-DAS polymer. Then, ROZ was added as the core, D-A-tocopherol polydiethylene glycol isosuccinate (TPGS) and HA-DAS were used as carriers to form HA-DAS and TPGS mixed micelle system loaded with ROZ (THDR-NPs). The size and structure of THDR-NPs were characterized, the drug release, stability and biosafety of THDR-NPs were studied. In vitro, the cytotoxicity, targeting effect and tumor metastasis inhibition of THDR-NPs were evaluated in human breast cancer cell lines. In addition, the selective potency of designed THDR-NPs in depleting was further verified in vivo in the tumor-bearing nude mice model. Results: The designed THDR-NPs have a particle size of less than 100 nm, good stability, biological safety and sustained release, and showed strong therapeutic effects on breast cancer models in vitro and in vivo. Moreover, it has been proved that THDR-NPs have the ability to inhibit tumor metastasis. Conclusion: DAS and ROZ were designed into micelles, the efficacy of THDR-NPs was higher than that of free drugs. These results indicate that nanoparticles have a good application prospect in the treatment of tumor metastasis.

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“…Hyaluronic acid (HA) has become one of the most used ingredients in cosmetic products. It is widely used as a moisturizing active ingredient in cosmetic formulations to enhance skin hydration and elasticity, resulting in softer, smoother and radiant skin [ 1 ]. HA is a natural occurring linear polysaccharide composed of repeating disaccharide units of D‐glucuronic acid and N‐acetyl‐D‐glucosamine [ 2 ], and it is one of the main components of the extracellular matrix in which cells and fibrous constituents of the matrix such as elastin and collagen are embedded [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Stringiness of hyaluronic acid emulsions

Kibbelaar

Deblais

Velikov

et al. 2021

Intern J of Cosmetic Sci

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Objective Cosmetic emulsions containing hyaluronic acid are ubiquitous in the cosmetic industry. However, the addition of (different molecular weight) hyaluronic acid can affect the filament stretching properties of concentrated emulsions. This property is often related to the “stringiness” of an emulsion, which can affect the consumer's choice for a product. It is thus very important to investigate and predict the effect of hyaluronic acid on the filament stretching properties of cosmetic emulsions. Methods Model emulsions and emulsions with low and high molecular weights are prepared and their filament stretching properties are studied by the use of an extensional rheometer. Two different stretching speeds are employed during the stretching of the emulsions, a low speed at 10 µm/s and a high speed at 10 mm/s. The shear rheology of the samples is measured by rotational rheology. Results We find that filament formation only occurs at high stretching speeds when the emulsion contains high molecular weight hyaluronic acid. The formation of this filament, which happens at intermediate states of the break‐up, coincides with an exponential decay in the break‐up dynamics. The beginning and end of the break‐up of high molecular weight hyaluronic acid emulsions show a power law behaviour, where the exponent depends on the initial stretching rate. At a lower stretching speed, no filament is observed for both high molecular weight and low molecular weight hyaluronic acid emulsions and the model emulsion. The emulsions show a power law behaviour over the whole break‐up range, where the exponent also depends on the stretching rate. No significant difference is observed between the shear flow properties of the emulsions containing different molecular weights hyaluronic acid. Conclusion In this work, we underline the importance of the molecular weight of hyaluronic acid on the elongational properties of concentrated emulsions. The filament formation properties, for example the stringiness, of an emulsion is a key determinant of a product liking and repeat purchase. Here, we find that high molecular weight hyaluronic acid and a high stretching speed are the control parameters affecting the filament formation of an emulsion.

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Hyaluronan-Based Nanohydrogels as Effective Carriers for Transdermal Delivery of Lipophilic Agents: Towards Transdermal Drug Administration in Neurological Disorders

Cited by 32 publications

References 45 publications

Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing

Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing

A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy

Stringiness of hyaluronic acid emulsions

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