Hyalinizing clear cell carcinoma of salivary glands: a study of extracellular matrix

Félix, Ana; Rosa, José; Nunes, J. F.; Fonseca, Isabel; Cidadão, António; Soares, Jorge

doi:10.1016/s1368-8375(01)00072-0

Cited by 34 publications

(24 citation statements)

References 15 publications

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“…Suzuki et al [17] 66/F Base of tongue Milky-white, firm, elastic 4 n/a n/a n/a n/a n/a n/a n/a cases (9.1%), in which one developed lymphoid follicles with germinal centers [8,12,21] No distinct morphologic characteristic such as necrosis or increased mitoses, or immunohistochemical profile, uniformly correlated with recurrence, aggressive behavior, or metastatic disease. Metastases and/or local recurrences were identified in approximately one-third of cases [1,2,5,7,8,10,15,22].…”

Section: Discussionmentioning

confidence: 99%

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

O’Sullivan‐Mejia

Massey

Faquin

et al. 2009

Head and Neck Pathol

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Hyalinizing clear cell carcinoma (HCCC) is an extremely rare neoplasm with a female predominance, composed of nests of monomorphic clear cells within a hyaline stroma. This tumor often follows an indolent course and treatment includes wide surgical excision with or without adjuvant radiotherapy. We report eight cases of HCCC identified at two academic institutions in six women and two men, ranging in age from 25 to 86 years. Histologically, all cases demonstrated cords, trabeculae, and nests of monomorphic clear cells as well as cells with eosinophilic granular cytoplasm. Mild cellular atypia was occasionally seen and mitoses were very rare. Seven cases demonstrated a hyalinized stroma, and one case, a myxoid stroma. Immunohistochemically, the tumor cells were positive for epithelial markers and negative for desmin and actin. Seven cases were negative for S-100. Cells were also positive for periodic acidSchiff and negative for mucin. The important clinicopathologic features and the differential diagnoses of HCCC, as well as a review of the literature are discussed.

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Section: Discussionmentioning

confidence: 99%

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

O’Sullivan‐Mejia

Massey

Faquin

et al. 2009

Head and Neck Pathol

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“…This is in line with the usual oral cavity location and frequent connection to the surface mucosal epithelium. Additional findings on electron microscopy include some basal lamina reduplication [12].…”

Section: Immunohistochemical and Ultrastructural Findingsmentioning

confidence: 96%

“…This designation may be because of the presumed salivary gland origin, and excluding mucinous differentiation was a convenient criterion in the differential diagnosis with MEC. Milchgrub et al and the WHO also quote the ultrastructural findings as showing evidence of glandular differentiation despite tonofilaments, desmosomes and cytoplasmic glycogen [1,3,12]; all more in keeping with squamous differentiation and with the morphologic appearance and overlap with MEC. This was first highlighted by Dardick, who reviewed the original ultrastructural images and concluded that HCCC is a squamous lesion [7].…”

Section: Proposed Line Of Differentiation and Issues With Nomenclaturementioning

confidence: 97%

“…They are almost invariably negative for S100, SMA, MSA, calponin and GFAP, ruling out myoepithelial differentiation. The hyalinized stroma is positive for collagen I and fibronectin but negative for collagen IV and laminin, arguing against this hyalinized stroma being basement membrane material [12]. Collagen IV and laminin are only positive in a thin layer around tumour nests [12].…”

Section: Immunohistochemical and Ultrastructural Findingsmentioning

confidence: 99%

“…The hyalinized stroma is positive for collagen I and fibronectin but negative for collagen IV and laminin, arguing against this hyalinized stroma being basement membrane material [12]. Collagen IV and laminin are only positive in a thin layer around tumour nests [12]. Ultrastructurally, the tumors have been shown to have tonofilaments, desmosomes and glycogen [1,3,13].…”

Section: Immunohistochemical and Ultrastructural Findingsmentioning

confidence: 99%

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Hyalinizing Clear Cell Carcinoma of Salivary Gland: A Review and Update

Weinreb

2013

Head and Neck Pathol

120

165

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Hyalinizing clear cell carcinoma (HCCC) is a rare minor salivary gland tumor made up of clear cells and forming cords and nests in a hyalinized stroma. The overall outcome is excellent with only occasional metastatic spread. HCCC has a wide differential diagnosis including other clear cell-containing tumors, such as epithelialmyoepithelial carcinoma, mucoepidermoid carcinoma, and myoepithelial carcinoma. HCCC is currently classified as a ''clear cell adenocarcinoma'' by the AFIP and as ''clear cell carcinoma, not otherwise specified (NOS)'' by the World Health Organization (WHO). It is considered by the WHO to be a diagnosis of exclusion. Since the original description in 1994, there have been few new insights into HCCC, until recently. Dardick re-examined the features of HCCC, including the original electron microscopic images, and concluded that HCCC is a squamous lesion, at odds with the above nomenclature. Bilodeau et al. recently showed that this tumor essentially cannot be separated reliably from clear cell odontogenic carcinoma (CCOC) except by location. Antonescu et al. recently identified a consistent EWSR1-ATF1 fusion in HCCC. Bilodeau et al. subsequently argued a link between these two entities, with evidence of similar EWSR1 and ATF1 rearrangements in CCOC. This molecular signature is not present in other clear cell mimics. Cases with recurrence, metastasis, highgrade features and other alternative morphologies or presentations have also been seen and proven by molecular analysis to be HCCC. In the molecular era, HCCC can no longer be seen as a diagnosis of exclusion. It is neither an adenocarcinoma nor a ''not otherwise specified'' tumor, as the AFIP and WHO currently classify it. This review provides an in-depth look at the current state of knowledge of HCCC from morphology to molecular features. New developments and personal insights are provided that help identify and properly classify this lesion.

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Hyalinizing clear cell carcinoma

Solar

Schmidt

Jordan

2008

Cancer

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BACKGROUD: Hyalinizing clear cell carcinoma (HCCC) is an uncommon malignant salivary gland tumor that was characterized only recently as a distinct entity. Because of its histologic similarity to several other primary and metastatic tumors and its purported favorable clinical outcome after local resection, it is important to recognize the features of this unusual tumor. METHODS: The authors present 8 new, fully characterized cases of HCCC and systematically reviewed 44 other cases of HCCC reported in the English language literature from 1980 to 2008. Historic cases were reviewed, and available data regarding morphology, special stains, demographics, clinical presentation, radiographic findings, management, and outcomes were extracted. Data from the current series were compared with the earlier published literature. RESULTS: To the best of the authors' knowledge, this was the largest reviewed series of HCCC and included a total of 52 cases. The findings, which included key histologic features, clinical presentation, and outcome, generally were consistent with what was reported previously. However, the current review revealed that 25% of patients reported in the literature had metastatases at initial presentation, including 10 of 44 patients who had metastases to regional lymph nodes and 1 patient who had metastasis to the lung. The authors were unable to identify any specific histologic features that would predict this behavior. CONCLUSIONS: The current results indicated that HCCC is less indolent than was believed previously; therefore, regional lymph node dissection should be considered in conjunction with wide local excision for patients with HCC. Cancer 2009. © 2008 American Cancer Society.

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Hyalinizing clear cell carcinoma of salivary glands: a study of extracellular matrix

Cited by 34 publications

References 15 publications

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

Hyalinizing Clear Cell Carcinoma of Salivary Gland: A Review and Update

Hyalinizing clear cell carcinoma

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