Hyalinizing clear cell carcinoma of the base of tongue: A distinct and rare entity

Abstract

Hyalinizing clear cell carcinoma (HCCC) of tongue is a rare neoplasm originating from minor salivary glands. We present a case of HCCC involving the base of tongue, in a 73-year-old male, clinically diagnosed as fibroma. Laser excision of the mass was done. Histopathological examination showed an infiltrating lesion composed predominantly of clear cells. The differential diagnosis included other salivary gland lesions having a clear cell component and metastatic clear cell renal carcinoma. Immunohistochemistry was useful in ruling out these lesions exhibiting clear cell component from clear cell carcinoma. Imaging studies revealed no lesion in either kidney. Since, HCCC has a better prognosis and the adequate treatment is wide excision, it needs to be differentiated from other carcinomas with clear cells. No further therapy was given to the patient. One year after the surgery, the patient is symptom free without local recurrence and on regular follow up.

Hyalinizing clear cell carcinoma of the head and neck: Case series and update

“…Our review of the literature revealed 130 cases of HCCC among 48 articles . We did exclude a number of articles that have been reported by others to represent HCCC but, in our view, did not provide sufficient histologic description to confirm the diagnosis .…”

Reappraising hyalinizing clear cell carcinoma: A population‐based study with molecular confirmation

“…HCCC characteristics were compared with other salivary gland carcinomas presenting to our institution using nonparametric Mann–Whitney U test for continuous variables, or Fisher exact test for dichotomous variables. Clinical outcomes of our cases combined with that of 99 reported HCCCs with available follow‐up from primary resection, were plotted using the Kaplan–Meier method. Duplicate (previously reported) cases were excluded.…”

Clear cell carcinoma of soft palate- A case report

“…Possibly, it arises from intercalated ducts as tumor cells stain positive for ck8 and ck18 and negative for myoepithelial markers and stratified squamous epithelial markers by IHC. [59]…”

“…A high degree of vascularity and pronounced atypia in addition to the lack of prominent hyaline stroma is generally regarded as a hallmark of renal cell carcinoma. [69]…”