Hyaline Vascular-Type Castleman Disease Presenting as an Esophageal Submucosal Tumor: Case Report

Kim, Ki Nam; Lee, Ki Nam; Kang, Myeong Jin; Roh, Mee Sook; Choi, Pil Jo; Yang, Doo Kyung

doi:10.3348/kjr.2006.7.1.73

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…However, since UCD represents a nodal proliferation, it can occur anywhere where lymphatic tissue is present; other common sites in the thorax include the hila, axillae, pleural space, chest wall, and extrapleural soft tissues (43,44,46,47). In rare instances, UCD has been reported in the trachea, esophagus, and even the lungs (41,42,48). Fortunately, although the location in the thorax can vary, the imaging manifestations of UCD are relatively consistent, as the majority of patients present with a solitary mass that demonstrates avid enhancement.…”

Section: Imaging Features Unicentric CDmentioning

confidence: 99%

Castleman Disease of the Thorax: Clinical, Radiologic, and Pathologic Correlation:From the Radiologic Pathology Archives

Kligerman¹,

Auerbach²,

Franks³

et al. 2016

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Castleman disease is a complex lymphoproliferative disease pathologically divided into two subtypes, the hyaline vascular variant (HVV) and the plasma cell variant (PCV). The HVV is the most common, is thought to represent a benign neoplasm of lymph node stromal cells, and is treated with surgical resection. It is most commonly found in the mediastinum, where it classically appears as a unicentric, avidly enhancing mass at computed tomography (CT) and magnetic resonance imaging. This appearance can mimic other avidly enhancing mediastinal masses, and location, clinical history, laboratory data, and nuclear medicine single photon emission CT (SPECT) and positron emission tomography (PET) studies can help narrow the differential diagnosis. Multicentric Castleman disease (MCD), which in the majority of cases is composed of the PCV, is an aggressive lymphoproliferative disorder associated with human herpesvirus infection, interleukin 6 dysregulation, and other systemic disorders. While it can be difficult to differentiate MCD from lymphoma, the presence of avidly enhancing lymph nodes can suggest the diagnosis. The purpose of this article is to review the clinical, immunologic, and pathologic findings associated with both unicentric Castleman disease and MCD and discuss how the imaging findings correlate with the pathophysiology of the disease.

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Section: Imaging Features Unicentric CDmentioning

confidence: 99%

Castleman Disease of the Thorax: Clinical, Radiologic, and Pathologic Correlation:From the Radiologic Pathology Archives

Kligerman¹,

Auerbach²,

Franks³

et al. 2016

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“…Laboratory tests, interview and physical and clinical examinations confirmed the presence of tumour in the pelvis minor. It is well-known that the most frequent location of Castleman's disease is the mediastinum (63%), then the retroperitoneal space (11%) and axial lymph nodes (4%) [14][15][16][17][18][19][20][21]. Occurrence of Castleman's tumour in localized form of the disease in the alimentary tract, colon or stomach is exceptionally rare.…”

Section: Discussionmentioning

confidence: 99%