Huygens Synchronization of Medial Septal Pacemaker Neurons Generates Hippocampal Theta Oscillation

Kocsis, Barnabás; Martínez-Bellver, Sergio; Fiáth, Richárd; Domonkos, Andor; Sviatkó, Katalin; Barthó, Péter; Freund, Tamás F.; Ulbert, István; Káli, Szabolcs; Varga, Viktor; Hangya, Balázs

doi:10.2139/ssrn.3773612

Cited by 1 publication

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“…MSDB VGluT2 + neurons fire mostly tonically during theta oscillations and their optogenetic stimulation drives theta activity and locomotion speed in a frequency dependent manner (Fuhrmann et al, 2015). Differently, a small subset of MSDB GABAergic neurons expressing PV display highly rhythmical discharge, phase locked to the ongoing theta oscillations (Kocsis et al, 2021) and their optogenetic activation controls the oscillatory frequency outside the endogenous theta range and does not affect locomotion (Zutshi et al, 2018). Those neurons are thus commonly referred to be the pacemakers of theta activity (Zutshi et al, 2018;Kocsis et al, 2021).…”

Section: Msdb Theta Activity and Locomotion Planningmentioning

confidence: 99%

“…Differently, a small subset of MSDB GABAergic neurons expressing PV display highly rhythmical discharge, phase locked to the ongoing theta oscillations (Kocsis et al, 2021) and their optogenetic activation controls the oscillatory frequency outside the endogenous theta range and does not affect locomotion (Zutshi et al, 2018). Those neurons are thus commonly referred to be the pacemakers of theta activity (Zutshi et al, 2018;Kocsis et al, 2021). The less explored type of theta oscillations is type 2 theta, proven to be dependent on the cholinergic MSDB system.…”

Section: Msdb Theta Activity and Locomotion Planningmentioning

confidence: 99%

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The Role of the Medial Septum—Associated Networks in Controlling Locomotion and Motivation to Move

Mocellin

Mikulovic

2021

Front. Neural Circuits

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The Medial Septum and diagonal Band of Broca (MSDB) was initially studied for its role in locomotion. However, the last several decades were focussed on its intriguing function in theta rhythm generation. Early studies relied on electrical stimulation, lesions and pharmacological manipulation, and reported an inconclusive picture regarding the role of the MSDB circuits. Recent studies using more specific methodologies have started to elucidate the differential role of the MSDB’s specific cell populations in controlling both theta rhythm and behaviour. In particular, a novel theory is emerging showing that different MSDB’s cell populations project to different brain regions and control distinct aspects of behaviour. While the majority of these behaviours involve movement, increasing evidence suggests that MSDB-related networks govern the motivational aspect of actions, rather than locomotion per se. Here, we review the literature that links MSDB, theta activity, and locomotion and propose open questions, future directions, and methods that could be employed to elucidate the diverse roles of the MSDB-associated networks.

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