HUS and TTP: Variable expression of a single entity

A Very Rare Complication of Carbon Monoxide Intoxication; Thrombotic Thrombocytopenic Purpura

“…Body temperature increased to 38.5º C at the same day, the level of consciousness appeared to be fluctuating, and there was a progressive decrease in platelet counts and hemoglobin. Hemoglobin levels decreased to 7.3 g/ dL, platelet count dropped to 11.000/mm 3 and LDH level was increased to 2212 U/L. INR, PT and aPTT values were normal.…”

“…As a presumable diagnosis, CO intoxication was considered. The laboratory findings were as follows, hemoglobin 16.1 g/dL, platelet count 261.000/mm 3 , blood urea nitrogen (BUN) 56 mg/ dL, creatinine 2.5 mg/dL, Na 146 mmol/L, K 4.1 mmol/L, lactate dehydrogenase (LDH) 1472 U/L and creatinine kinase (CK) 88.15 U/L. In arterial blood gas analysis performed upon admission, PO 2 was 75 mmHg; PCO 2 was 30 mmHg and pH was 7.48.…”

“…Early diagnosis and treatment reduce the morbidity and mortality rates [2]. Thrombotic thrombocytopenic purpura (TTP) is a rare condition, characterized by fever, acute renal failure, thrombocytopenia, microangiopathic hemolytic anemia (MAHA), and neurological abnormalities [3]. In this study we report a case of carbon monoxide intoxication complicated with TTP in a 46 year old male patient.…”

Renal thrombotic microangiopathies/thrombotic thrombocytopenic purpura in a patient with primary Sjögren’s syndrome complicated with IgM monoclonal gammopathy of undetermined significance

“…typically presents with varying degrees of the pentad of Coombs-negative hemolytic anemia, thrombocytopenia, acute renal failure, neurological disturbances, and fever [1].…”

Thrombotic Microangiopathy-Kidneys and Beyond: Historic Lessons

“…However, basing on the overlap in clinical signs and symptoms and common pathology of TTP and HUS, Remuzzi, discussing these issues in 1987, declared: "In the absence of criteria, that can differentiate between HUS and TTP, I favor the view that these term describe different clinical expressions of the same disease, a disease, characterized by microangiopathy, hemolytic anemia, renal failure and, sometimes, neurologic involvement. A diagnosis of this disease, which I shall term HUS/ TTP, should be entertained whenever acute hemolytic anemia of the microangiopathic type is associated with thrombocytopenia and any degree of renal damage" [35].…”