HuR-induced circ_0082319 contributes to hepatocellular carcinoma by elevating PTK2 through miR-505-3p

Qin, Chuntang; Liu, Shuyan; Chen, Weibin; Xue, Dan; Guo, Tianli; Wu, Baojiang

doi:10.1007/s00210-023-02793-y

Naunyn-Schmiedeberg's Arch Pharmacol

2023

DOI: 10.1007/s00210-023-02793-y

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HuR-induced circ_0082319 contributes to hepatocellular carcinoma by elevating PTK2 through miR-505-3p

Chuntang Qin,

Shuyan Liu,

Weibin Chen

et al.

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2024

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Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis

Tian,

Zhang,

Liu

et al. 2024

Front. Immunol.

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Hepatocellular carcinoma (HCC) is a significant contributor to cancer-related deaths in the world. The development and progression of HCC are closely correlated with the abnormal regulation of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Important biological pathways in cancer biology, such as cell proliferation, death, and metastasis, are impacted by these ncRNAs, which modulate gene expression. The abnormal expression of non-coding RNAs in HCC raises the possibility that they could be applied as new biomarkers for diagnosis, prognosis, and treatment targets. Furthermore, by controlling the expression of cancer-related genes, miRNAs can function as either tumor suppressors or oncogenes. On the other hand, lncRNAs play a role in the advancement of cancer by interacting with other molecules within the cell, which, in turn, affects processes such as chromatin remodeling, transcription, and post-transcriptional processes. The importance of ncRNA-driven regulatory systems in HCC is being highlighted by current research, which sheds light on tumor behavior and therapy response. This research highlights the great potential of ncRNAs to improve patient outcomes in this difficult disease landscape by augmenting the present methods of HCC care through the use of precision medicine approaches.

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Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis

Tian,

Zhang,

Liu

et al. 2024

Front. Immunol.

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show abstract

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HuR-induced circ_0082319 contributes to hepatocellular carcinoma by elevating PTK2 through miR-505-3p

Cited by 1 publication

References 54 publications

Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis

Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis

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